Uses of Necaral 4

Glimepiride in Necaral 4 is known to be a new generation of hypoglycemic sulfamide belonging to the group of sulfonylureas used in the treatment of type 2 diabetes.
This ingredient has both intra- and extra-pancreatic effects. In the pancreas, Glimepiride works by stimulating insulin release by the beta cells of the islets of Langerhans. At the same time, this effect is based on the increased responsiveness of these cells to the physiological stimulus, glucose. Outside the pancreas, Glimepiride has been shown to improve the sensitivity of peripheral tissues to insulin and to decrease hepatic insulin recovery. Glimepiride exerts an effect on blood glucose recovery by mediated by cell membrane transport proteins.
This ingredient is unaffected by food, but absorption is slightly slower with food. After 2 hours and 30 minutes from the time the drug enters the body, the maximum concentration in the blood plasma will be reached. Glimepiride is very low distribution
Necaral-4 4mg is indicated for glycemic control in patients with non-insulin dependent type 2 diabetes mellitus. For the drug to be highly effective, patients need to combine it with diet and exercise.
However, the drug is not indicated in the following cases:
Patients with hypersensitivity to any component of the drug are not allowed to prescribe the drug. Patients with insulin-dependent diabetes mellitus, coma, and diabetic ketoacidosis. Patients with impaired liver and kidney function Female in pregnancy and breast-feeding patients.

2.1. How to use Necaral-4 4mg is made in the form of uncoated tablets, so patients need to take the drug orally. When taking the drug, it is necessary to swallow the tablet whole, do not break it in half or crush it to avoid affecting the medicinal properties of the drug. Do not take the medicine with alcoholic beverages or fruit juices.
Patients are recommended to take the drug once a day, can be taken at breakfast time.
2.2. Dosage The dose of the drug depends on the purpose of treatment of the disease and the patient's condition. Patients should not arbitrarily change the dose or stop taking the drug suddenly without a doctor's prescription. Below is the reference dose of Necaral 4:
The starting dose of previously untreated patients is 1-2 mg/day. Dosage for patients who have been treated with antidiabetic drugs before will be 1-2 mg / day, up to a maximum of 2 mg / day. Patients with debilitated, malnourished or elderly patients are prescribed 1 mg/day. Maintenance dose for patients already receiving glimepiride 1 mg/day, increased to 2 mg/day if desired blood glucose levels are still not achieved after 1-2 weeks of treatment; After up to 2 mg dose, subsequent dose adjustment depending on tolerance and response is 1 - 4 mg/day. The doctor will assign the patient to increase the dose slowly, each time increasing no more than 2 mg / day, at intervals of 1-2 weeks; up to 8 mg/day.

Although before prescribing, the doctor carefully considers the benefits that the drug brings to outweigh the risks, however, during treatment, patients may still experience some side effects such as: blood glucose. Some of the most common side effects of Necaral 4 are: Dizziness, dizziness, headache, nausea, vomiting, feeling of fullness in the epigastric region, abdominal pain, diarrhea ...
The above is not all side effects of the drug. Therefore, during the course of taking the drug, if you experience any unusual symptoms, you should notify your doctor to receive timely treatment.

There have been reports of drug interactions between Necaral 4 and some drugs such as Insulin, oral diabetes drugs, Chloramphenicol, Coumarin derivatives, MAOIs, Acetazolamide, diuretics, Barbiturates, Phenytoin, Glucagons, anticoagulants Coumarin... see and advise doctor or pharmacist. At the same time, in order to use the drug safely, the patient must not arbitrarily stop taking the drug or change the dose of the drug without the permission of the doctor.

To use the drug safely, patients need to be careful with the above notes:
Necaral 4 may cause loss of blood glucose control when the patient is stable on the diabetes treatment regimen, but the symptoms appear. stressors such as fever, injury, infection, or surgery. In addition, the patient may also have an increased risk of hemolytic anemia, cardiovascular disease, hypo or hyperglycemia, impaired vision ... The drug can significantly affect people who regularly operate machines and driving.