Uses of Pbalphadol

What is Pbalphadol? The drug Pbalphadol contains the active ingredient Alfacalcidol with a concentration of 0.25 mcg and other excipients in sufficient quantities. This drug belongs to the group of minerals and vitamins for the body. Pbalphadol is used to treat diseases caused by disorders of calcium metabolism leading to a decrease in endogenous synthesis of 125-dihydroxy vitamin D3.
Pbalphadol drug is prepared in the form of soft capsules, suitable for direct oral use. Packing is a box of 10 blisters and each blister contains 10 pills.
1.1. Pharmacodynamics of active ingredient Alfacalcidol: Active ingredient Alfacalcidol is a substance similar to Vitamin D, acting as a regulator of calcium and phosphate metabolism. Its active metabolite 1,25-dihydroxyvitamin D3 binds to receptors distributed in target tissues, intestine and bone. This is where physical activity takes place, including absorption of calcium from the intestines, dissolution of bone minerals, and bone formation.
1.2. Pharmacokinetics of the active ingredient Alfacalcidol The pharmacokinetics of drugs belonging to the group of minerals and vitamins Pbalphadol are intended for use by professionals or persons with specialized knowledge only. You should not research and apply it yourself without professional knowledge.

Pbalphadol is used in the treatment of the following pathologies:
Indicated in the treatment of diseases caused by disorders of calcium metabolism leading to a decrease in the synthesis of endogenous 125-dihydroxy vitamin D3, including: Renal osteodystrophy; Postoperative or spontaneous hypoparathyroidism; Pseudoparathyroidism; Rickets or osteomalacia resistant to Vitamin D; Vitamin D-dependent rickets; Decreased blood calcium or rickets in infants; Calcium malabsorption; Osteoporosis in postmenopausal women.

3.1. How to use Pbalphadol Drug Pbalphadol is prepared in the form of soft capsules, suitable for direct oral use.
3.2. Dosage of Pbalphadol The dose of Pbalphadol should be carefully adjusted, based on the individual's blood calcium levels. Dosage is indicated as follows:
For adults and children over 20kg:
Dosage for treatment of renal dystrophy 0.5 -1μg Dosage for treatment of hypoparathyroidism and other diseases caused by metabolic abnormalities vitamin D is 1.0 – 4.0μg For children:
Dosage for treatment of postmenopausal osteoporosis is 1μg; Maintenance dose 0.25μg – 1μg per day For the elderly use 0.5 μg/day
Note: Dosage is adjusted according to age and disease symptoms of each specific person.

Undesirable effects of Pbalphadol that may occur during use are as follows:
Active ingredient Alfacalcidol is usually easily tolerated. However, there are also some undesirable effects that often occur during treatment, such as increased calcium in the blood, which can be quickly corrected by discontinuing this drug until calcium levels return to normal. . In addition to increased calcium in the blood, there are some other undesirable effects such as: loss of appetite, nausea, vomiting, abdominal cramps, diarrhea, constipation, stomach pain, itching, rash, conjunctival congestion, increased GOT, GPT, LDH and y-GOT indexes. Inform your doctor about any unwanted effects you experience while using Pbalphadol.

Interactions of Pbalphadol drugs that may occur during use are as follows:
Glycoside digitalis: For people with hypercalcemia, digitalis can cause cardiac arrhythmias. Therefore, you need to be careful when using digitalis with Alfacalcidol concurrently. Barbiturates, Anticonvulsants and Enzyme Inducers: People using barbiturates or enzyme-inducing anticonvulsants may need to increase the dose of the active ingredient Alfacalcidol to achieve the desired results. Drugs affecting intestinal absorption: the absorption of the active ingredient Alfacalcidol may be impaired when used concomitantly with mineral oil (long-term use), cholestyramine, colestipol, sucralfate or large amounts of aluminum-containing antacids. . Magnesium: Use caution when administering magnesium-containing antacids or laxatives to patients undergoing prolonged hemodialysis who are being treated with drugs containing the active ingredient Alfacalcidol. An increase in magnesium in the blood may occur. Calcium/Thiazide: The risk of hypercalcemia is usually high for people who use the combination of drugs containing the active ingredient Alfacalcidol with products containing calcium or thiazides. Vitamin D and derivatives: Active ingredient Alfacalcidol is the main derivative of Vitamin D. You should not combine the use of Pbalphadol with vitamin D or its derivatives. This is due to the potential to increase the effect of the drug leading to the risk of increased calcium in the blood.

During the use of Pbalphadol, patients should note:
6.1. Contraindications of the drug Pbalphadol Pbalphadol is contraindicated for people with hypercalcemia.
6.2. Precautions for Pbalphadol Serum calcium levels should be checked regularly during treatment and the dose should be adjusted so that serum calcium levels do not exceed the normal range. For the elderly, it is necessary to be careful in using the drug in the elderly because the body function gradually declines. For children: Treatment of children with Pbalphadol should be started with a low dose and then gradually increased. For pregnant and lactating women: Only use Pbalphadol as prescribed by the treating doctor after weighing the possible benefits and risks. Store Pbalphadol in a dry place, away from direct light. In addition, it is necessary to keep the drug Pbalphadol out of the reach of children and family pets. Absolutely do not use Pbalphadol after the expiry date.
Above is all information about Pbalphadol, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Pbalphadol to treat the disease at home, because there may be unwanted side effects on health.
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