Uses of Pracitum

What is Pracitum used for? What are the side effects of Pracitum, dosage and precautions when using it? Let's find out information as well as how to use Pracitum through the article below.

Pracitum is an antibiotic used in the treatment of moderate and severe infections in adults and the elderly. Pracitum uses the main antibacterial active ingredient, Piperacilin, a broad-spectrum penicillin antibiotic belonging to the beta-lactam family.
Pracitum is prepared as a powder for injection, each dose includes 1 vial and 1 ampoule containing solvent. The content in one dose of Pracitum includes 2g (2000mg) Piperacilin and 250mg Sodium Tazobactam.

The antibacterial effect of Pracitum is based on the piperacilin component of the drug, this active ingredient is a ureido of a broad-spectrum antibacterial penicillin. Therefore, Pracitum has a bactericidal effect against aerobic and anaerobic bacteria (Gram Positive and Gram Negative). The bactericidal mechanism of Pracitum is to act on the bacterial cell wall, making the bacteria unable to synthesize and duplicate itself.
Pracitum is particularly sensitive to Gram-positive cocci such as Sreptococcus, Enterococcus, Clostridium perfringens, anaerobic cocci. Pracitum is sensitive to Gram-negative aerobic bacteria such as E.coli, Proteus indol-positive, Proteus mirabilis, Serratia, Enterobacter spp, Pseudomonas, Citrobacter spp strains, Salmonella, Shigella, Gonococcus and Meningococcus, Haemophilus influenzae which does not produce beta-lactams. , Acinetobacter, Klebsiella, Fusobacterium spp., Bacteroides.

Pracitum can only be used intravenously or intramuscularly, because Piperacilin is not absorbed from the gastrointestinal tract. With the intravenous route with a dose of 2g, the plasma concentration reached from 30-70 microgram/ml in the blood plasma after about 30 minutes of injection.
With an intramuscular dose of 2g, the maximum plasma concentration is 30-40 micrograms/ml after 30-40 minutes of injection. Pracitum is well distributed to tissues and body fluids, and even to the cerebrospinal fluid in meningitis.
Pracitum is eliminated from 60 to 80% of the dose in the urine, 20% in the bile in the unchanged state. The plasma half-life of the drug is about 1 hour, in patients with renal failure, the elimination time and elimination rate will also be longer than normal.
With broad antibacterial spectrum and drug distribution in the body, Pracitum is an antibiotic indicated in the treatment of severe bacterial infections, including bacteremia.

Treatment of moderate to severe infections in adults, adolescents and the elderly. Lung infection due to hospital stay. Urinary tract infections (including pyelonephritis). Intra-abdominal infections, biliary tract infections, gallbladder infections. People with gonorrhea are uncomplicated by penicillin-sensitive cocci. Skin and soft tissue infections. Treatment of systemic infections caused by Pseudomonas, patients with neutropenia, it is necessary to combine with aminoglycosides in treatment. Infection after abdominal surgery, infection after uterine surgery.

Pracitum is contraindicated in patients with chronic hypersensitivity to penicillins, cephalosporins or beta-lactam inhibitors.

Pracitum is administered intravenously and intramuscularly. Administration includes slow intravenous injection over 3 - 5 minutes or slow intravenous infusion over 20 - 30 minutes. The solution used to dissolve the drug can be used as 5% or 30% glucose, 0.9% NaCl, 6% dextran, 20% Mannitol, distilled water for injection.
Dosage of Pracitum in adults and children over 12 years old: 2000mg Piperacilin, 250mg Sodium tazobactam - 4000mg Piperacilin, 500mg Sodium tazobactam, each dose is 6-8 hours apart. In patients with decreased neutrophils, a dose of 4000mg Piperacillin, 500mg Sodium tazobactam every 6 hours and in combination with Aminoglycosides as prescribed by the doctor Piperacilin, 10mg tazobactam sodium/kg body weight, used every 6 hours and in combination with aminoglycosides as prescribed by the doctor. The maximum dose should not exceed 4000mg Piperacilin, 500mg Sodium tazobactam every 6 hours. In patients with impaired renal function, the dose of Pracitum should be adjusted according to the prescription of a specialist.

According to records from clinical studies, users of Pracitum may experience side effects such as diarrhea, nausea, skin rash, and vomiting.

Although Pracitum has a good killing effect on Gram-positive cocci, penicillinase-producing staphylococci are resistant to the drug. The main active ingredient of Pracitum is easily reduced by beta lactamases. The antibiotic Piperacilin, when combined with tazobactam, is active against Gram-negative and Gram-positive aerobic and anaerobic bacteria, including piperacillin-resistant beta-lactamase-producing organisms. The combination of Pracitum with aminoglycosides will be effective in critically ill patients, but the two drugs must be injected separately because simultaneous injections will cause incompatibilities. The combined effect of Pracitum with aminoglycosides is indicated in the treatment of multi-resistant P. aeruginosa infections. Concomitant use of Pracitum with Probenecid will prolong the half-life of Pracitum in the body. Concomitant administration of Pracitum with tobramycin, gentamicin in patients with severe renal impairment will increase the clearance of the drug. Concomitant use of Pracitum with anticoagulants will affect the patient's blood coagulation system. Co-administration with Vecuronium may cause prolonged neuromuscular blockade. While using Pracitum, the patient may develop pseudomembranous colitis. For pregnant and lactating women, it should only be used in mandatory and necessary indications. Pracitum is not recommended for use in children under 2 years of age.