Uses of Praverix 500mg

"What is Praverix 500mg?". Praverix 500mg medicine contains the active ingredient Amoxicillin 500mg - an antibiotic belonging to the Betalactam group. Amoxicillin acts by inhibiting bacterial cell wall synthesis through inhibition of peptidoglycan cell wall, thereby rendering bacterial wall cells incomplete and causing bacterial death.
Amoxicillin has a spectrum of activity against both gram-negative and gram-positive bacteria as follows:
Gram-positive bacteria: Staphylococcus aureus (Staphylococcus Aureus), Haemolytic streptococcus (Streptococci spp), penicillinase-resistant staphylococcus (Staphylococcus epidermidis), Streptococcus pneumoniae (Streptococcus Pneumoniae)...; Gram-negative bacteria: Salmonella, Haemophilus Influenzae, Shigella, Helicobacter Pylori...; Amoxicillin does not work on bacteria such as Proteus vulgaris, Klebsiella pneumoniae, M.catarrhalis that produce Beta - lactamase...
"What effects does Praverix 500mg have and in what cases is it indicated?". Accordingly, Praverix 500mg medicine contains the active ingredient Amoxicillin 500mg antibiotic indicated in the following diseases:
Upper respiratory tract infections and lower respiratory tract infections such as bronchitis, pneumonia, rhinitis, sinusitis ; Severe urinary tract infections such as pyelonephritis, cystitis; Genital tract infections caused by certain susceptible bacteria; Gastrointestinal infections, dental infections, skin and soft tissue infections.

Praverix 500mg medicine is made in the form of hard capsules, taken orally. The patient should swallow the tablet whole, avoid chewing or crushing it will affect the effect of the drug.
The dose of Praverix 500mg depends on the age, condition of the patient and the type of infection and the patient has. The recommended dosage of Praverix is ​​as follows:
Adults and adolescents weighing over 40kg: Take 750mg - 3g/day divided into 3-4 times; Adolescents and children weighing less than 40kg: Dosage is calculated by weight, the recommended dose is 25-50mg/kg body weight/24 hours; Patients with renal impairment: Praverix dose is adjusted based on creatinine clearance. For patients with creatinine clearance less than 10ml/min, the dose is 500mg/24 hours, for patients with creatinine clearance greater than 10ml/min, the dose is 500mg/12h. Patients need to adhere to the dosage and course of drug treatment. In case the disease symptoms have improved after 1-2 days of taking Praverix 500mg, the patient should not arbitrarily stop using the drug when the symptoms have improved, but need to finish the dose as prescribed by the doctor. treatment. Because abrupt discontinuation of the drug will increase the risk of recurrence of more severe infections and increase the risk of drug resistance.
In case the disease symptoms do not improve after 5 days of treatment with Praverix 500mg, the patient should notify the doctor or pharmacist.

Praverix 500mg medicine can cause some side effects as follows:
Common: Diarrhea, nausea, vomiting. Patients can limit the risk of experiencing nausea and vomiting side effects by taking the drug before meals. Diarrhea side effects usually go away after 2 days of taking the drug, however, in case loose stools persist for more than 2 days or more than 6 times a day, the patient should stop using Praverix and notify the treating doctor; Some other side effects: Cholestatic jaundice, increased liver enzymes, bullous dermatitis, exfoliative dermatitis, skin pustules, dizziness, headache, fever, crystaluria, transient leukopenia, raised eyebrows urticaria, pruritus, loss of appetite, anorexia, prolongation of bleeding time and prolongation of prothrombin time.

4.1. Contraindications Contraindicated to use Praverix 500mg in the following cases:
Patients with a history of allergy to Amoxicillin or to antibiotics of the Penicillin, Cephalosporin group; Patient has infectious mononucleosis. 4.2. Caution when using Praverix 500mg For patients with impaired renal function, Praverix 500mg should be considered to reduce the dose based on creatinine clearance. Patients should adhere to the dose of the drug exactly as prescribed by the treating doctor, do not arbitrarily change the dose or duration of treatment.
In case the infection does not improve after 5 days of treatment, the patient should stop using Praverix and go to a medical facility to be re-diagnosed.
"Can Praverix 500mg be used for pregnant women?". Scientific studies show that Amoxicillin does not affect fetal development. However, Praverix should only be used in pregnant women when absolutely necessary and should be prescribed by the treating doctor.
Patients treated with Praverix should have their liver and kidney function checked periodically. Avoid drug therapy in patients with suspected infectious mononucleosis.
For women who are breast-feeding: Praverix 500mg is excreted in breast milk, so caution should be exercised when taking the drug during lactation.
Drivers, operating machines: Amoxicillin has little effect on the patient's ability to drive and operate machines.

Praverix 500mg can interact with some of the following drugs:
Using Praverix with anticoagulants such as warfarin can prolong blood prothrombin time; Methotrexate toxicity is increased when used concomitantly with Amoxicillin because Amoxicillin reduces the elimination of Methotrexate, increases blood concentrations and increases the risk of unwanted effects; The renal half-life of Amoxicillin is increased with concomitant use of Probenecid; Nifedipine increases the absorption of Amoxiclin; Using Amoxicillin with bacteriostatic antibiotics affects the bactericidal effect of drugs such as Erythromycin, Chloramphenicol, Tetracycline; Amoxicillin reduces the effectiveness of oral contraceptives. Therefore, you may need to use another method of oral contraception while being treated with Praverix. Drug interactions occur that reduce the therapeutic effect of Praverix, increasing the risk of unwanted effects. Therefore, patients need to inform the treating doctor of all medicines they are using (over-the-counter drugs, prescription drugs) and dietary supplements before treatment with Praverix to ensure safety and effectiveness. during treatment.