Uses of Pregasafe

Pregasafe drug is used in the case of pain due to nerve causes, support in the treatment of epilepsy. In addition, the drug is also used with other uses under the direction of the doctor. To know more about the effects, uses and notes when using the drug, please refer to the article below.

Pregasafe drugs with the main ingredient is Pregabalin, which is made in the form of hard capsules with the following content:
Pregasafe 50 mg contains 50mg of Pregabalin; Pregasafe 75mg contains 75mg of Pregabalin. The drug has an inhibitory effect on nerve transmission, through the mechanism that pregabalin binds to subunit α2-δ protein of calcium current carrying action potentials in the central nervous system, replacing substance [3H]-gabapentin.
Pregabalin is rapidly absorbed when taken orally in the fasted state and peak plasma concentrations are reached 1 hour after both single and multiple dosing. The oral bioavailability of Pregabalin is approximately 90% and is dose dependent. The rate of absorption of Pregabalin is decreased when taken with food. However, in fact, taking Pregabalin with food has no clinically significant effect on the extent of Pregabalin absorption. Therefore, the medicine can be taken on an empty stomach or on an empty stomach.

Pregasafe is indicated for use in the following cases:
Treatment of neuropathic pain: Pregabalin is indicated in the treatment of adult neuropathic pain such as sciatica, brachial plexus pain, Intermittent nerve pain ...; Treatment of partial seizures: Pregabalin is indicated as adjunctive therapy in adults with partial seizures, possibly in cases of secondary generalization; Treatment of Generalized Anxiety Disorder: Pregabalin is indicated for the treatment of anxiety disorders in adults. Do not use Pregasafe in people who are sensitive to any component of the drug. People under 18 years of age should not use it because the safety of the drug has not been established. Use with caution in patients with renal failure.
3. Dosage and use of the drug Pregasafe How to use: Pregasafe is taken orally and can be taken with or without food.
Dosage: The usual dose of Pregasafe is 150 mg - 600 mg per day in 2 to 3 divided doses.
Dosage in case of neuropathic pain:
Treatment with Pregasafe may begin with a dose of 150mg per day, divided into 2 to 3 times; Depending on individual patient response and tolerability, the dose may be increased to approximately 300 mg/day after an interval of 7 days, if necessary, to a maximum dose of 600 mg/day after approximately 7 days. treatment day with a dose of 300mg; However, in many cases with a dose of 600 mg does not significantly increase the therapeutic effect and increase side effects, it is recommended to use a dose of less than 600 mg. Dosage in case of epilepsy:
Treatment with Pregasafe may begin with a dose of 150mg per day divided into 2 to 3 oral doses; Following individual response and tolerability, the dose may be increased to 300 mg/day after approximately 1 week and, if necessary, to a maximum dose of 600 mg/day after approximately 1 week of treatment with a dose of 300 mg. . Dosage in Generalized Anxiety Disorder:
Dosage required for treatment of anxiety disorders should be reassessed at regular intervals. Treatment with Pregasafe can be started at a dose of about 150mg per day; Depending on individual response and tolerability, the dose may be increased to 300 mg/day after approximately 1 week of treatment; After an additional week of treatment, the patient's dose can be increased to 450 mg/day; A maximum dose of 600 mg/day can be achieved after 1 week of subsequent treatment. But only increase when absolutely necessary; Patients with renal impairment: Reduce dose and duration of administration in patients with impaired renal function. Dosage is used according to creatinine clearance (CLcr):
Creatinine clearance (CLcr) ≥ 60, starting dose is 150mg and maximum dose is 600mg. Divided into 2 or 3 doses; Creatinine clearance (CLcr) ≥ 30 and < 60, starting dose is 75 mg and maximum dose is 300 mg. Divided into 2 or 3 doses; Creatinine clearance (CLcr) ≥ 15 and < 30, starting dose is 25-50mg and maximum dose is 150mg. Divided into 2 doses or taken as a single dose; Creatinine clearance (CLcr) less than 15, starting dose is 25mg and maximum dose is 75mg. To be given a single dose; Support dose after hemodialysis: The starting dose is 25mg and the maximum dose is 100mg. Take a single dose. Use in patients with hepatic impairment: No dosage adjustment is required in patients with hepatic impairment.
Use for people over 65 years old: Elderly people may need to reduce the dose of Pregabalin because of decreased kidney function.
Note in case of discontinuing Pregasafe: If you have to stop using Pregasafe, you need to gradually reduce the dose for at least 1 week.

When taking the drug you may experience some side effects including:
Very common: Dizziness, drowsiness; Common: Increased appetite, euphoria, irritability, irritability, decreased libido, disorientation, insomnia, ataxia, abnormal coordination, tremor , poor physical condition, memory impairment, inability to concentrate, paresthesia, loss of balance, lethargy, blurred vision, double vision, dizziness. Nausea and vomiting, dry mouth, constipation, flatulence. Erectile dysfunction, fatigue, peripheral edema, edema, weight gain; Uncommon: Nasopharyngitis, dyspnea, dry nose, loss of appetite, hypoglycemia, skin rash, sweating, falls, thirst, chest tightness, weakness, chills. Hallucinations, feelings of assault, apathy, anxiety, depression, restlessness, mood swings, difficulty expressing information, daydreams, increased libido, apathy, stupor, fainting, myoclonic jerks, psychomotor hyperactivity, loss of taste, dyskinesia, postural vertigo, tremor, nystagmus, cognitive disturbances, decreased reflexes, decreased tactile sensations, loss memory, burning sensation. Visual disturbances, decreased vision, decreased sharpness in vision, eye pain, eye fatigue, dry eyes, increased hearing. Tachycardia, atrioventricular block. Muscle spasticity, swelling of joints, cramps, muscle pain, arthralgia, back pain, muscle spasm pain. Urinary incontinence or urinary retention. Increased liver enzymes such as Alanin aminotransferase (ALT), increased Aspatate aminotransferase (AST); decrease in platelet count. Some rare cases: Neutropenia, loss of conditioned reflexes, happy mood, decreased muscle movement, impaired sense of smell, difficulty in writing. Flickering vision, changes in image depth, dizziness, eye irritation, dilated pupils, strabismus, bright images. Hypotension or hypertension, tachycardia, arrhythmia, bradycardia. Abdominal distention, abdominal pain, gastroesophageal reflux, increased salivation, loss of taste, pancreatitis, difficulty swallowing. Nosebleeds, hives, cold sweats. Renal failure, oliguria, amenorrhea, lactation, breast pain, mammary gland enlargement, hypokalemia, decreased number, generalized edema, fever. Smoking withdrawal syndrome. When experiencing side effects of the drug, you need to stop using and notify your doctor or if serious, immediately go to the nearest medical facility for timely treatment.

The drug is used according to the doctor's prescription, so you need to inform your doctor about your allergy and accompanying diseases before taking the drug; Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine because the excipients contain lactose; Some patients with diabetes may experience weight gain while taking Pregabalin, so the use of hypoglycemic agents should be adjusted; Pregabalin treatment often causes dizziness and drowsiness, which may increase the risk of traumatic accidents in the elderly. Therefore, caution should be exercised when using the drug; The drug can cause drowsiness, dizziness, so it is not recommended to operate machinery or move vehicles because of the risk of causing an accident; Although no relationship has been found between long-term or high-dose use and withdrawal symptoms after discontinuation of the drug. But if necessary, the drug should be stopped gradually over 1 week; For pregnant and lactating women, the use of this drug is not recommended. So only use drugs when absolutely necessary; As with other antiepileptic drugs, the use of Pregasafe is also associated with factors such as suicidal ideation and behavior, and drug abuse. Close monitoring is recommended especially in those at high risk such as a history of depression; The drug is excreted almost completely in its pure form by the kidneys, so there is almost no obvious interaction with other drugs; Note to store the medicine in a cool place, away from moisture, out of reach of children. In short, Pregasafe is a drug that is used under a doctor's prescription, you must not stop taking it or take it without your doctor's prescription.