Uses of Sagapanto

Sagapanto is an gastrointestinal drug with the main ingredient being Pantoprazol Sodium Sesquihydrate. The drug is manufactured at Thien Dan International Pharmaceutical Trading Co., Ltd. So how should Sagapanto be used?

Sagapanto is a specific and irreversible inhibitor of the proton pump. Due to its selective action on the cell wall of the stomach, it acts faster and more effectively than other drugs. The ulcer healing rate can reach up to 95% after 8 weeks of treatment.
Sagapanto has little effect on pepsin secretion, gastric juice volume, intragastric factor and gastric contractility.

Sagapanto 40 is indicated in some of the following cases:
Peptic ulcer disease Gastroesophageal reflux disease (GERD). Used in combination with appropriate antibiotics for eradication of Helicobacter pylori in patients with peptic ulcer to heal ulcer and prevent recurrence.

3.1 Tablet form Recommended dosage: Patients with gastric and duodenal ulcers, Helicobacter pylori infection (positive), should perform the eradication of bacteria with combination therapy. Depending on the type of drug resistance, the following combination schemes can be used to eradicate Helicobacter pylori as follows:
Treatment regimen 1: Use twice daily x (1 tablet of Pantoprazole + 1000mg of amoxicylline + 500mg of clarithromycin) x 7 days.
Treatment regimen 2: Use twice daily x (1 tablet of Pantoprazole + 500mg of metronidazol + 500mg of clarithromycin) x 7 days.
Treatment regimen 3: Use twice daily x (1 tablet of Pantoprazole + 1000mg of amoxicilline + 500mg of metronidazol) x 7 days.
For patients with gastroesophageal reflux disease (GERD): Take 1 tablet of 40mg/day. For patients with severe hepatic impairment, the dose should be reduced to 1 tablet (40 mg pantoprazole), administered every two days. In addition, it is necessary to monitor liver enzymes during the course of Sagapanto, liver enzyme values ​​​​increase, should stop taking the drug. Do not exceed 40mg Sagapanto a day in the elderly or in patients with renal impairment. Except for the case of combination therapy for eradication of Helicobacter pylori, in which the elderly must also take the usual dose of Sagapanto (2 x 40 mg/day) for one week of treatment. How to use and duration of treatment
Do not chew or crush Sagapanto tablets, but take them whole with water. Take one hour before breakfast. In combination therapy for the eradication of Helicobacter pylori, the second Sagapanto tablet should be taken before dinner. In case of forgetting to take the medicine on time, do not take a make up dose later in the day. You should continue to take your normal dose the next day of the course. The above combination therapy requires only 7 days of treatment to kill Helicobacter pylori and heal ulcers. 3.2 Intravenous form The injectable Sagapanto is recommended when oral administration is not appropriate. The average intravenous dose of Sagapanto is 1 vial (40 mg pantoprazole) per day. The maximum dose can be up to 6 vials/day divided into several times.
Instructions on how to use and prepare Sagapanto injection form:
Intravenous use: Inject 10ml of physiological saline solution (0.9% NaCl solution into the powder vial containing Sagapanto lyophilized 40mg, inject slowly intravenously at least 2 hours. minutes Intravenous use: Dilute Sagapanto with 100ml of physiological saline or 100ml of Glucose 5% or 100ml of Glucose 10%, intravenous infusion at least 15 minutes.Do not mix or mix Sagapanto with any solvents. Note that the pH value of the solution should be 9. The reconstituted solution (prepared) should be used within 12 hours of preparation, otherwise it must be discarded. .

When using Sagapanto, caution should be exercised in some of the following cases:
Sagapanto 40 injection should only be used when oral administration is not appropriate. Before treatment with Sagapanto 40, the possibility of malignant gastric ulcer or malignant esophagitis must be excluded. Because it can temporarily obscure the symptoms of ulcerative colitis, it can delay diagnosis. There is currently no experience with the treatment of Sagapanto 40 in children, so care should be taken when administering it to young children. It is not clear whether the drug Sagapanto 40 is used when driving or operating machinery.

Sagapanto 40 should not be used in patients with a history of sensitivity to pantoprazole.
According to clinical experience, there is limited use of Sagapanto 40 during pregnancy. There is currently no information on the excretion of Sagapanto 40 in human milk. However, Sagapanto 40 should only be used when the benefits to the mother are considered to outweigh the risks to the fetus and baby.

Pantoprazole may decrease the absorption of other concomitantly administered drugs whose absorption is pH dependent (eg, ketoconazole). The same is true for drugs taken shortly before Sagapanto 40.
The active substance of Sagapanto 40 is metabolized in the liver by the cytochrome P450 enzyme system. The possibility that Sagapanto 40 interacts with other drugs metabolised with the cytochrome P450 enzyme system cannot be excluded. However, clinically significant interactions have not been observed in specific trials with certain drugs or compounds of these properties, such as carbamazepine, caffeine, diazepam, diclofenac, digoxine, ethanol, glibenclamide, metoprolol, nifedipine, phenprocoumon, phenytoin, theophylline, warfarine and oral contraceptives.
Sagapanto 40 did not interact with antacids (stomach pain) when taken concurrently.
No interactions Sagapanto 40 with antibiotics used in combination (clarithromycine, metronidazol, amoxicylline) in the treatment of Helicobacter pylori eradication.

During treatment with Sagapanto 40 may occasionally have headache or mild diarrhea and, more rarely, nausea, upper abdominal pain, flatulence, skin rash, itching and dizziness.
A few rare cases occur such as edema, fever, thrombophlebitis.

To date, no symptoms have been observed with overdosage of Sagapanto 40 in humans. In the event of overdose and clinical intoxication, the usual rules of detoxification apply.
The above are the main uses of Sagapanto 40, patients should carefully read the accompanying instructions and follow the doctor's instructions for the best treatment results before using.