Uses of Samfixime Sachet

Samfixime Sachet belongs to the group of antiparasitic, anti-infective, antiviral, antifungal drugs used to treat fungal infections. Below is detailed information about what drug Samfixime Sachet is and what precautions should be taken when using it.

Samfixime Sachet is prepared in the form of powder for oral suspension, with the main ingredient being Cefixime 100mg. Cefixime is a 3rd generation cephalosporin antibiotic with bactericidal effect due to inhibition of bacterial cell wall synthesis. The drug has strong activity against gram-negative bacteria and is stable to beta-lactamases, but is less active against gram-positive bacteria than penicillins and first-generation cephalosporins.
The antibacterial spectrum of Cefixime includes: Streptococcus pyogenes, S. .pneumoniae, S. agalactiae, E.coli, Klebsiella species, Proteus mirabilis, P. aeruginosa, Haemophilus influenzae, H.Parainfluenzae (including beta-lactamase-producing strains), Neisseria meningitidis, N.gonorrhoeae (including secreting strains) penicillinase), Moraxella catarrhalis (including beta-lactamase-producing strains)...
Cefixime is well absorbed from the gastrointestinal tract and parenteral route, metabolised by the liver and eliminated mainly by the kidneys.

Samfixime Sachet is used in the following cases:
Uncomplicated urinary tract infections Nephritis - pyelonephritis, complicated urinary tract infections caused by Enterobacteriaceae, but the treatment effect is less than that of bacterial infections. uncomplicated urinary tract. Uncomplicated gonorrhea Pharyngitis, tonsillitis, otitis media. Acute or chronic bronchitis. Mild or moderate community-acquired pneumonia. Dysentery, typhoid. Do not use Samfixime Sachet in the following cases:
Hypersensitivity to Cefixime or other cephalosporins. Children under 6 months old

Adults and children over 12 years old: 400mg/day. Urinary tract infections caused by gonococcal: 400mg single dose or 200mg twice a day. Children from 6 months to 12 years old: 8mg/kg/day as a single dose or 4mg/kg x 2 times/day. It is necessary to adjust the dose for patients with renal failure. The course of treatment is usually from 5 to 10 days.

When using Samfixime Sachet, you may experience some of the following undesirable effects:
Unwanted effects are usually transient with mild or moderate severity.
Common:
Gastrointestinal disturbances: usually occur in the first 1-2 days of treatment and respond to symptomatic drugs, rarely requiring discontinuation of the drug. Fatigue, headache, dizziness, restlessness, insomnia, fever, erythema, drug urticaria. Uncommon:
Severe diarrhea due to Clostridium difficile, pseudomembranous colitis Anaphylaxis, angioedema, erythema multiforme, Stevens-Johnson syndrome Leukopenia, eosinophils, transient platelets Decrease in hemoglobin and hematocrit Inflammation liver, jaundice, increased liver enzymes AST, ALT, bilirubin, alkaline phosphatase, LDH Increased blood creatinine levels, acute renal failure Inflammation, vaginal candidiasis. Rarely, convulsions and prolongation of prothrombin time may occur. When using Samfixime Sachet, if the patient experiences any serious side effects, stop taking the drug, immediately contact the treating doctor or go to the medical facility for timely handling.

When combined with Samfixime Sachet may interact with the following drugs:
Probenecid, Nifedipine reduces clearance, increases plasma concentrations of the drug. Concomitant use with vitamin K antagonist anticoagulants (warfarin) prolongs prothrombin time, increases the risk of bleeding Increases plasma concentrations of carbamazepine when used in combination.

When using Samfixime Sachet, caution should be exercised in the following cases:
A history of allergy to penicillins and cephalosporins should be carefully explored before using the drug because of cross-sensitivity between beta-lactam antibiotics. Caution should be exercised in people with a history of gastrointestinal disease, colitis, especially with prolonged use because it may increase the risk of overgrowth of resistant bacteria. Dosage and frequency of administration should be reduced when treating patients with renal impairment. There are no data on the safety and efficacy of the drug in children under 6 months of age. No dose adjustment is necessary in the elderly, unless there is impaired renal function (creatinine clearance CrCl < 60 ml/min) Use during pregnancy only when clearly needed because there are insufficient data. study on drug use in this subject. Should be used with caution in lactating women, because it is not certain whether the drug is excreted in breast milk or not. The drug does not affect the ability to drive or use machines. In addition to the above information, if you have any questions about Samfixime Sachet, you can contact your doctor for advice and answers.