Uses of Seodeli

1.1. Indications Seodeli 200mg drug containing active ingredient Trimebutin malenat is indicated in the following cases:
Symptoms of spasmodic pain caused by disorders of the gastrointestinal tract, small intestine, stomach, biliary tract and large intestine; Esophageal reflux and esophageal spasm (vomiting, belching, hiccups, difficulty swallowing...); Colon spasms and irritable bowel syndrome (IBS) with bloating, cramping, diarrhea, or diarrhea alternating with constipation. 1.2. Pharmacodynamics Active ingredient Trimebutin is a non-competitive antispasmodic agent that regulates lower gastrointestinal motility. The effects of trimebutin were not affected by atropin or hexamethonium concentrations, but the effect was reduced with increasing calcium concentrations.
Trimebutin has been shown to have an effect on the duodenum, stomach, ileum, jejunum and colon. Gastric activity was slightly inhibited or remained unchanged. Meanwhile, the activity of the small intestine is significantly increased (the activity of the duodenum is stronger than that of the jejunum and ileum, especially the part of the intestine with abnormal activity).
Trimebutin has a strong local anesthetic effect, the anesthetic effect is stronger and longer lasting than procaine, cocaine and lidocaine.
1.3. Pharmacokinetics Absorption: Trimebutin is rapidly absorbed after oral administration. Plasma drug concentrations peak about 1 hour after oral administration. Distribution: The protein binding of trimebutin is quite low (about 5%). The mean distribution half-life of the drug is about 0.66 hours, with high concentrations in the stomach and intestinal wall. Metabolism: Seodeli is extensively metabolised in the liver to several metabolites. Excretion: The drug is excreted mainly in the urine, with a small amount of the drug and its metabolites (about 5 - 12%) found in the faeces.

Seodeli tablet is used orally, the dose depends on the patient's condition and ability to respond. The recommended dose is as follows:
Adults: The maximum recommended dose is 1 tablet/time x 3 times/day; It is not recommended to use the drug in the treatment of children under 12 years of age.

Seodeli 200mg drug can cause some side effects as follows:
On the digestive tract: Diarrhea, dry mouth, bad taste, epigastric pain, constipation and nausea; On the central nervous system: Fatigue, somnolence, feeling hot/cold and headache, dizziness; Allergic rash reaction; Other side effects: Painful enlargement of breasts, menstrual problems, anxiety, urinary retention, mild deafness. In case of experiencing side effects, the patient should stop using the drug and notify the treating doctor for timely treatment.

4.1. Contraindications Contraindicated to use the drug in patients with hypersensitivity to Trimebutin or to any component of the drug Seodeli 200mg.
4.2. Note when using Driver, operate machinery: Seodeli drug may cause side effects on the central nervous system (sleep, fatigue, dizziness...). Therefore, patients need to be cautious and avoid jobs that require high concentration when experiencing the above side effects. Pregnant women: Studies on the teratogenicity of Seodeli have shown that there is no link between the drug's adverse effects on the fetus by both injection and oral route. However, to ensure safety, it is not recommended to use Seodeli in these subjects. Lactation: Do not use Seodeli in lactating women.

The results of animal studies show that trimebutin maleate enhances the effects of d-tubocurarin. In addition, no other drug interactions were reported in clinical trials. However, the patient needs to inform the doctor about the drugs being treated as well as allergy and irritant drugs.
Seodeli medicine 200mg contains the active ingredient Trimebutin maleate, is indicated in the treatment and symptom relief of irritable bowel syndrome, promoting intestinal motility after surgery in patients with paralytic ileus... To ensure effective treatment To treat and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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