Uses of the drug Leninrazol 40

Leninrazol 40 is prepared in the form of long film coated enteric tablets containing the active ingredient Esomeprazole. Esomeprazole belongs to the class of proton pump inhibitors, the mechanism of action by binding to the H+/K+ ATPase pump in the parietal cells of the stomach and specifically inhibiting this enzyme, preventing the final step of acid secretion into the stomach. thick. Therefore, Esomeprazole has the effect of inhibiting basic gastric acid secretion and also when stimulated with any agent.
Leninrazol 40 is indicated in the following cases:
Treatment of Zollinger - Ellison syndrome; Treatment of severe gastroesophageal reflux disease (GERD) including erosive esophagitis, stricture, or ulceration of the esophagus as determined by endoscopy; Used in the treatment regimen of stomach ulcers caused by Helicobacter Pylori bacteria.

Dosage of Leninrazol 40 is prescribed by the doctor based on the patient's condition. The drug is prepared in the form of film-coated tablets that dissolve in the intestines, so patients absolutely do not split, crush or chew the tablet, but need to swallow the whole tablet. Some recommendations on the dosage of Leninrazol 40 are as follows:
Adults over 18 years old:
Treatment of severe gastroesophageal reflux disease with esophagitis: Take 40mg/time/day for 4-8 weeks. The duration of treatment can be extended by 4 - 8 weeks if the symptoms do not go away or the endoscopy shows that there is still inflammation; Treatment of gastric and duodenal ulcers caused by Helicobacter Pylori (HP): Esomeprazole in combination with antibiotics in the treatment regimen for gastritis caused by HP. The recommended dose is 40mg/time/day for 10 days; Treatment of Zollinger - Ellison syndrome: The recommended starting dose is 40mg/time/day, then adjust the dose depending on the patient's response. Once the symptoms are under control, the medication can be stopped and surgery is used to remove the tumor; Patients with impaired renal function: No dose adjustment is required;
Patients with impaired liver function: No need to adjust the dose in patients with mild to moderate hepatic impairment, patients with severe liver impairment should not take more than 20mg/day.
Children under 18 years: Do not use the drug in children under 18 years of age because the effectiveness and safety have not been proven.
Elderly: No dose adjustment is required in the elderly.

Leninrazol can cause some side effects as follows:
Common: Headache, skin rash, dizziness, nausea, vomiting, diarrhea, abdominal pain, flatulence, constipation, dry mouth; Uncommon: Drowsiness, fatigue, rash, pruritus, visual disturbances; Rare: Sweating, fever, peripheral edema, fever, photosensitivity, hypersensitivity reactions (angioedema, urticaria, bronchospasm, anaphylaxis), depression, agitation, confusion , hallucinations, leukopenia, agranulocytosis, thrombocytopenia, hepatitis, increased liver enzymes, jaundice, impaired liver function, arthralgia, myalgia, taste disturbances, Stevens-Johnson syndrome.. .

The use of Leninrazol 40 is contraindicated in patients with hypersensitivity to Pantoprazol or any of its components, hypersensitivity to drugs of the Benzimidazole subclass or to proton pump inhibitors.
Be careful when using Leninrazol in the following cases:
Before treatment with Esomeprazole in particular as well as with proton pump inhibitors in general, the patient should be excluded the possibility of stomach cancer, because the drug has can mask symptoms and delay cancer diagnosis; Be careful when treating with Leninrazol 40 for a long time because of the risk of causing atrophic gastritis; The risk of drug interactions should be considered when prescribing Leninrazol in the treatment of HP; For pregnant women: Leninrazol 40 should not be used during pregnancy, unless the benefits outweigh the risks; Breast-feeding: There is no information on the safety of use in women who are breast-feeding. Therefore, use Leninrazol only when the benefits outweigh the risks; For drivers, operating machines: Leninrazol 40 can cause headaches, dizziness, blurred vision, dizziness... so patients need to be careful when driving or operating machinery.

Concomitant administration of Leninrazol 40mg, Amoxicillin and Clarithromycin increases blood levels of 14-Hydroxyclarithromycin (metabolites of Clarithromycin) and Esomeprazole in the blood. Leninrazol 40 increases the area under the curve (AUC) and prolongs the half-life of cisapride. Active ingredient Esomeprazole inhibits the enzyme CYP2C19. Therefore, the concomitant use of Esomeprazole with drugs metabolized via CYP2C19 enzyme will increase plasma concentrations of these drugs, eg Citalopram, Diazepam, Clomipramine, Imipramine, Phenytoin... Active ingredient Esomeprazole is proven. demonstrated no clinically significant effect on the pharmacokinetics of Quinidine, Amoxicillin. Esomeprazole is metabolised by the enzyme CYP3A4, so co-administration of Leninrazol 40 with a CYP3A4 inhibitor doubles the AUC of Esomeprazole. Drug interactions occur that reduce the therapeutic effect of Leninrazol 40, increasing the risk of unwanted effects. Therefore, patients need to inform their doctor about the drugs and supplements they are using before being treated with Leninrazol.
Leninrazol 40 containing the active ingredient Esomeprazole is indicated in the treatment of gastroesophageal reflux disease, Zollinger - Ellison syndrome... If during use, the patient does not know all the information, please Consult your doctor for effective use.
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