Uses of the drug Pagetbol

Pagetbol has the main ingredient Pamidronate disodium, used to treat osteoporosis, bone loss in breast cancer patients, malignant tumors causing hypercalcemia. Let's find out more details about the uses and notes when using Pagetbol through the article below.

What is Pagetbol? Pagetbol medicine is prepared in the form of soft capsules, packaged in boxes of 3 blisters x 10 capsules.
Each Pagetbol softgel contains:
Active ingredient: Pamidronate disodium 100mg. Other excipients: Soybean Oil, Partially Hydrogenated Soybean Oil, Palm Oil, White Beeswax, Concentrated Glycerin, Lecithin, Gelatin, D-sorbitol, Ethyl vanillin, Titanium Dioxide, Red No. 40, Color gold number 203, Pure water.

The drug Pagetbol is used in the following cases:
Metabolic bone disease caused by calcium imbalance: Osteoporosis. Treatment of the following diseases: bone loss in breast cancer patients, malignant tumors causing hypercalcemia.

Daily dose of Pagetbol: Use a single dose, take the drug 1 hour before meals. At high doses of Pagetbol, ​​it can be divided into 2-3 doses. Adjust the dose of Pagetbol according to age or medical condition. Patients take Pagetbol pills with 1 or 2 cups of water in the stomach for good absorption. Pagetbol should not be taken with anything other than water. In patients with mild to moderate renal impairment (5 mg/dL), no dosage adjustment of Pagetbol is required. However, in patients with severe renal impairment, the dose should be reduced or the half-life monitored. Osteoporosis: The usual dose is 200mg pamidronate/day. The best treatment effect is achieved with Pamidronate treatment for about 3-4 years. Metastatic bone loss in breast cancer patients: To prevent, compensate for the calcium loss of bone resorption, reduce bone pain and hyperkalemia: use 300 ~ 600 mg Pamidronate/day for a long time. Malignant hypercalcaemia: Pamidronate is used in mild to moderate elevations of serum calcium (serum calcium 12 - 13.5 mg/dl), starting dose is based on serum calcium concentration, dose 300—900 mg Pamidronate (up to 1200 mg Pamidronate).

Pagetbol should not be used in patients with a history of hypersensitivity to this drug or other bisphosphonates.

Pagetbol should not be taken with other bisphosphonates or Plicamycin (mithramycin).
In patients with abnormal red blood cell counts, red blood cell counts should be monitored during the first week of Pagetbol therapy.
Metabolic parameters associated with hypercalcaemia such as serum phosphate, calcium, magnesium and potassium levels must be carefully monitored after initiating therapy with pamidronate.
People with Paget's disease of bone are at risk of vitamin D or calcium deficiency, need to take oral calcium supplements and vitamin D to minimize the risk of hypocalcaemia. For children: The safety and efficacy of Pagetbol have not been established.
Pregnancy: There are no adequate and well-tested uses of Pagetbol in pregnancy. Therefore, the drug Pagetbol should not be used during pregnancy.
Lactation: It is not known whether pamidronate is excreted in human milk. However, patients should be cautious when taking Pagetbol while breastfeeding.

Preparations containing vitamin D or calcium (including calcifediol and calcitriol): Concomitant administration of Pagetbol may antagonize the effect of pamidronate in the treatment of hypercalcemia.
Pamidronate has been used in combination with calcitonin in patients with severe hypercalcemia, producing a synergistic effect that results in a more rapid decrease in serum calcium.
Pagetbol should not be taken with foods high in calcium such as milk or antacids.

Pagetbol is well tolerated, and side effects are generally mild and transient.
Common side effects such as: Fever, fatigue, headache, nausea/vomiting, indigestion. Uncommon: Skin rash, angioedema, leukopenia, hypersensitivity reactions. Patients should inform their doctor or pharmacist of the unwanted effects encountered when using Pagetbol medicine.
In case of overdose of the drug Pagetbol may experience some symptoms such as: hypocalcemia, changes in electrocardiogram, convulsions, hemorrhage, paresthesia, spasticity of the hands and feet, fever. In this case, hypocalcaemia should be treated with intravenous calcium and symptomatic supportive treatment; Fever and hypotension can be treated with corticosteroids. Pagetbol has the main ingredient Pamidronate disodium, used to treat osteoporosis, bone loss in breast cancer patients, malignant tumors causing hypercalcemia. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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