Uses of the drug Parogic

Parogic is a drug that has antidiarrheal effects by reducing intestinal motility, used in cases of acute or chronic diarrhea caused by inflammatory bowel disease, irritable bowel syndrome. However, in some cases, improper use of the drug can cause the pathogen to be retained.

Parogic drug has the main ingredient Loperamide 2mg, prepared in hard capsule form. Loperamide has the effect of slowing intestinal motility through direct effects on nerve endings, ganglia of the intestinal wall. The drug works by blocking the cholinergic and noncholinergic mechanisms involved in reducing the activity of the sphincter and longitudinal muscles in the intestinal wall.
Loperamide prolongs the transit time of substances through the intestine and thus has the effect of reducing stool volume, increasing the viscosity and dry density of stool, avoiding the loss of fluids and electrolytes through the gastrointestinal tract.

Indications: Parogic is indicated for use in the following cases:
Relieves acute nonspecific diarrhea, chronic diarrhea caused by inflammatory bowel disease. Decreasing stool volume in patients undergoing ileostomy. Treatment of symptoms of acute diarrhea in adults and children 12 years of age and older to avoid the risk of dehydration, electrolyte loss. Contraindications: Parogic is contraindicated in the following cases:
Hypersensitivity to loperamide or excipients; Patients should avoid taking drugs that inhibit intestinal motility; Patients with impaired liver function; Diarrhea associated with pseudomembranous colitis or enterotoxin-producing bacteria; Dysentery syndrome; Because taking the drug traps the bacteria that cause the disease and can make the condition worse. Acute infectious diarrhea caused by bacteria capable of penetrating deep into the intestinal mucosa such as E. coli, Salmonella, Shigella. Distention; The use of Parogic should be stopped immediately when intestinal obstruction, constipation, abdominal distension occur. Children under 12 years old.

How to use: The drug is taken orally, taking the drug with water may not be affected by food.
Dosage:
Acute diarrhea: Adults: start with 4mg, then reduce to 2mg after each loose stool, maximum use 16mg/day; Children: Use the drug on the first day from 2mg 3 times a day, from the second day use 1mg / 10kg after each loose stool, the total dose / day of the 2nd day should not exceed the dose of the first day. Chronic diarrhea: Adults: Use at a dose of 4 - 8 mg/day once or divided into several times; Children: No recommended dose has been studied.

When using Parogic you may experience unwanted effects, including:
Common: Constipation, causing abdominal pain, nausea, vomiting. Uncommon: Dizziness, headache; Abdominal bloating, dry mouth; When experiencing side effects of Parogic drugs, it is necessary to stop using the drug and immediately notify the doctor or go to the nearest medical facility for timely treatment.

In patients with diarrhea, dehydration and electrolyte loss may occur, in which case it should be combined with appropriate rehydration and electrolyte therapy, which is also considered the most important measure. In patients with acute diarrhea, if there is no clinical improvement within 48 hours, the patient with fever should not continue taking Loperamide, but the cause of the diarrhea should be re-examined. In particular, it should be avoided if there is an infection because it keeps the causative agent in the body. Patients with liver dysfunction when taking the drug should be closely monitored for signs of CNS toxicity. For AIDS patients taking this drug to treat diarrhea, it should be discontinued at the earliest symptoms such as a feeling of abdominal distension. Pregnant and lactating women: There are no reports that should be avoided in this population. Drug Interactions: Co-trimoxazole may increase the bioavailability of loperamide. Storage: It is necessary to store Parogic in a tightly closed package, avoid direct light and avoid high temperatures above 30 degrees Celsius. Keep the medicine out of reach of children. Hopefully, with the above information about the drug, you already know what Parogic drug works and how to use it effectively. Avoid use if infection is thought to be present and if symptoms do not improve, reevaluate the cause.