Uses of the drug Pyme OM20

Pyme OM20 is a medicine used for the prevention and treatment of peptic ulcers. The main ingredient of the drug is Omeprazol 20mg and is made in the form of hard capsules.

Pyme OM20 medicine has the main ingredient Omeprazol 20mg and excipients just enough. Omeprazole has the effect of inhibiting the proton pump in the stomach wall, inhibiting gastric acid secretion reversible.
With the above uses, Pyme Om20 is indicated for the following cases:
Treatment of gastric and duodenal ulcers and gastric and duodenal ulcers; Used in combination with antibiotics in the treatment of gastrointestinal ulcers in patients with H.Pylori infection; Treatment of Zollinger Ellison syndrome ; Treatment of heartburn, esophagitis; Treatment of gastroesophageal reflux disease (GERD).

Pyme OM20 is made in the form of a hard capsule, so users take it whole on an empty stomach, do not chew or crush the tablet. Dosage of the drug should be according to the doctor's prescription, the reference Pyme OM20 dose for each condition is as follows:

To relieve symptoms of acid indigestion, take Pyme OM20 at a dose of 10-20mg/day for 2-4 weeks.

To treat peptic ulcer: Take 1 tablet of Pyme Om20/time/day. Use for 4 weeks if duodenal ulcer and 8 weeks if gastric ulcer. Maintenance dose: 10-20mg/time/day.

To kill H.Pylori bacteria in peptic ulcers, it is necessary to combine drugs containing Omeprazole with other antibiotics in dual or triple therapy. For example:
Omeprazol 20mg/time x 2 times/day, combined with (Amoxicillin 500mg, Metronidazol 400mg)/time x 3 times/day, maintain treatment for 1 week; Omeprazole 20mg, Clarithromycin 500mg, Metronidazol 400mg/ Tinidazol 500mg, orally twice a day. Maintain for 1 week; Omeprazole 20mg x 2 times / day, Amoxicillin 750mg - 1000mg / time, 2 times a day or Clarithromycin 500mg / time, 3 times a day. Maintain for 2 weeks.

Usual dose: Take 20mg x 1 time / day for 4 weeks. Continue for another 4 - 8 weeks if the condition has not improved. In case of persistent esophagitis, doses up to 40mg/day can be used; Maintenance dose: After healing of esophagitis, take 20mg once a day and for acid reflux, use 10mg daily.

Initial dose: Take 60mg/time/day and adjust according to need. The therapeutic dose can be in the range of 20 - 120 mg/day. If the dose is higher than 80mg, divide it into 2 doses/day. During the surgical treatment of Zollinger - Ellison syndrome, a dose of 40mg should be taken the evening before surgery and an additional 40mg 2 to 6 hours before the procedure.

No dose adjustment of Pyme Om20 is required in patients with renal impairment and the elderly (>65 years); For patients with hepatic impairment, it should be noted that the bioavailability and elimination half-life of the drug is increased in this subject, so a dose of 10-20mg/day is required; Experience with Omeprazole treatment in children is limited, so it is not recommended to use the drug in these subjects.

Some side effects may be encountered when taking Pyme Om20 medicine:
Common side effects:
Dizziness, drowsiness, headache; Nausea and vomiting; Abdominal pain, bloating; Constipation . Uncommon side effects:
Temporary increase in liver enzymes; Urticaria, itching, rash; Insomnia, fatigue. Rare side effects:
Peripheral edema, sweating,; Reversible confusion, depression; Hallucinations, agitation in critically ill patients; Hypersensitivity reactions such as: fever, anaphylaxis, angioedema; Blood disorders (leukopenia, thrombocytopenia, agranulocytosis); Visual disturbances, breast enlargement in men; Stomatitis, dry mouth ; Hepatic encephalopathy, jaundice, hepatitis; Bronchospasm, interstitial nephritis, myalgia, arthralgia. During the treatment with Pyme OM20, if the user encounters the above conditions, they should stop using and consult a doctor to avoid prolonged or worsening side effects.

Pyme Om20 is contraindicated in the following subjects:
People with hypersensitivity to Omeprazol and other components of the drug; Women who are breastfeeding (need to stop breastfeeding if you want to take the drug). Particular caution should be taken when using Pyme Om20 in the following cases:
Pregnant women or intending to become pregnant; Patients with liver failure; People who need to focus on driving, operating machinery and equipment.

Pyme OM20 may have an interaction reaction when used in combination with other drugs. Some cases can be mentioned:
Increase the concentration of Cyclosporin in the blood, increase the effect of some antibiotics to kill H. Pylori such as Metronidazol, Amoxicillin, increase the anticoagulant effect of Dicoumarol; Omeprazole is metabolised by the cytochrome P450 enzyme, so it can inhibit the metabolism of some drugs metabolized by this enzyme, increasing the concentration of Diazepam, Phenytoin, Warfarin in the blood. Pyme OM20 reduces the absorption of Itraconazole and Ketoconazole, reduces the metabolism of nifedipine by at least 20% and may increase the effect of nifedipine. Clarithromycin may increase the plasma concentration of Omeprazole. To be safe and prevent adverse drug interactions, inform your doctor about all medications, dietary supplements you are taking as well as your medical history for advice on potential interactions. out.