Uses of the drug Simvasboston 10

Simvasboston 10mg drug is often used to treat primary hypercholesterolemia, hypertriglyceridemia or mixed dyslipidemia,... Before and during the use of Simvasboston 10mg, patients need to ensure that Follow the medication schedule recommended by your doctor.

Simvasboston 10mg belongs to the group of cardiovascular drugs, used by doctor's prescription to reduce the levels of total cholesterol, bad cholesterol LDL, triglycerides and apolipoprotein B. At the same time, the drug also helps to increase the level of good cholesterol HDL in people with high cholesterol. primary blood.
Each Simvasboston 10 tablet contains the following ingredients:
Active ingredient: Atorvastatin (as Atorvastatin calcium trihydrate) 10mg. Other excipients: Lactose, Avicel, vitamin E powder, citric acid, magnesium stearate, pregelatinized starch, butylated hydroxyanisole, HPC, HPMC, stearic acid, titanium dioxide, PEG 6000, ponceau 4R lake, yellow number 6 lake and talcum powder .

2.1 Uses of the drug Simvasboston 10mg The main active ingredient Atorvastatin in the drug Simvasboston 10 belongs to the Statin group, which has the ability to competitively inhibit HMG-CoA reductase, thereby preventing the conversion of HMG-CoA to Mevalonate - a precursor form. cholesterol substance. Active ingredient Atorvastatin has the ability to inhibit cholesterol biosynthesis, helping to reduce cholesterol in liver cells, while supporting the stimulation of LDL receptor synthesis to increase LDL transport from the blood.
The above biochemical process of Atorvastatin helps patients with primary hypercholesterolemia to significantly reduce plasma cholesterol levels, specifically:
Increases the level of good HDL cholesterol in the blood from 5 to 15%. Reduces the level of bad LDL cholesterol in the blood by 25-61%. Reduces plasma triglyceride levels by 10 to 30%. In addition, the active ingredient Atorvastatin in the drug also plays an important role in the primary prevention of coronary heart disease (level 1) for people with high cholesterol who have risk factors for coronary events.
After oral administration, Atorvastatin is rapidly absorbed without being affected by food. The bioavailability of Atorvastatin is relatively low, and peak plasma concentrations can be reached in as little as 1-2 hours.
According to research, Atorvastatin has very high protein binding (>98%) and can cross the blood-brain barrier. The drug is extensively metabolised in the liver to inactive or inactive metabolites. The main route of elimination of Atorvastatin is in the feces and a small amount less than 2% in the urine
2.2 Indications for use Simvasboston 10mg Currently, doctors often prescribe Simvasboston 10 to treat conditions The following conditions are present:
Use as an adjunct to the patient's diet during the treatment of primary hypercholesterolemia type IIa, hypertriglyceridemia type IV, and mixed dyslipidemia type IIb. Used to support primary prevention of coronary events for people with high risk factors for developing the disease, but not yet having clinical manifestations. Reduce your risk of having a heart attack, dying from heart disease or having to undergo coronary revascularization procedures. Indications Simvasboston 10 to reduce or slow the progression of coronary atherosclerosis 2.3 Contraindication to using Simvasboston 10mg Do not use Simvasboston 10 for the following special cases:
Patients with hypersensitivity or reactions are allergic to the active substance Atorvastatin, other Statins or excipients contained in the medicine. Simvasboston 10 is contraindicated in patients with progressive liver disease, persistent elevation of serum transaminases of unknown cause. Simvasboston 10 should not be used by pregnant women and nursing mothers.

3.1 How much should Simvasboston 10 be used? Here is the dose of Simvasboston 10 according to the general recommendations of the doctor:
Starting dose: Take 10mg Atorvastatin / time / day. Maintenance dose: Take 10-40mg/day. If necessary, the dose can be increased to no more than 80mg/day. Dose for children and adolescents 10-17 years of age: Initial dose is 10mg/time/day, titrated every 4 weeks to reach a maximum dose of 20mg/time/day. Patients should initiate treatment at a dose that is tailored to their individual needs and response, and should be spaced more than 4 weeks apart until maximum dose is reached and desired LDL cholesterol levels are reached. In the case of using the drug together with the resin attached to the bile acid should take Simvasboston 10 at bedtime and 2 hours apart with the drug attached to the resin to avoid interaction.
3.2 How to take Simvasboston 10 as recommended Simvasboston 10 is taken orally and can be used as a single dose at any time of the day, such as on an empty stomach or with a meal. To achieve optimal treatment effect, patients need to apply a cholesterol-restricted diet before taking Simvasboston 10. Besides, patients should maintain this regimen throughout the course of treatment. According to the doctor's recommendation, Simvasboston 10 should be taken in the evening because the effect of the drug will be increased because cholesterol synthesis in the liver takes place mainly at night.

Overall, Simvasboston is well tolerated and has a lower discontinuation rate than other lipid-lowering agents. Here are some unwanted side effects that you may experience while taking Simvasboston 10mg, including:
Increased blood sugar . Cognitive impairment such as confusion or memory loss. Increased HbA1c. Constipation, diarrhea, abdominal pain. Nausea. Headache. Blurred vision. Dizzy. Insomnia. Joint or muscle pain. Skin rash. Muscle disease. Rhinitis or sinusitis. A cough. Myositis and rhabdomyolysis cause acute renal failure secondary to myoglobinuria. You need to tell your doctor right away if any of the side effects mentioned above occur while using Simvasboston.

5.1 Care and attention should be paid to treatment when using Simvasboston 10? During the course of treatment with Simvasboston 10mg, you need to be cautious of the following: incontinence, dysproteinemia, nephrotic syndrome, alcoholism or other drug use. Patients should have their total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides measured. Lipid measurement should be measured periodically less than 4 weeks / time to adjust the dose of Simvasboston 10 to suit the patient's response. Simvasboston 10 should be used with caution in people with risk factors for muscle damage, such as elderly patients, people with kidney disease, or uncontrolled hypothyroidism. If there are symptoms of acute myopathy or risk factors for acute renal failure due to rhabdomyolysis, such as hypotension, severe acute infection, severe trauma, seizures, or metabolic problems, Endocrine. Simvasboston 10mg should be used with caution in people with a history of liver disease and heavy drinkers. For people with hypothyroidism, impaired liver and kidney function, a history of hereditary myopathy or due to previous Statins / Fibrates, people over 70 years of age at risk of rhabdomyolysis or alcoholics should take it CK test before treatment with Simvasboston 10. If CK results are above 5 times the upper limit of normal, you should not use Simvasboston 10mg. If there are symptoms such as muscle weakness, pain or stiffness, the patient should immediately notify the doctor and perform a CK test for appropriate intervention. Simvasboston 10 should only be used in women of childbearing age who are definitely not pregnant and who have very high blood cholesterol levels but have not responded to other medications. 5.2 Interactions of Simvasboston 10 with other drugs Some drugs have the potential to interact with Simvasboston 10, including:
Simvasboston used together with other fibrin cholesterol-lowering drugs, Gemfibrozil, high-dose Niacin, Erythromycin, etc. Colchicine, Ketoconazole, Cyclosporin, and Itraconazole may increase the risk of muscle damage. Increase the effect of Warfarin and increase Prothrombin time when co-administered with Simvasboston 10mg. Reduced bioavailability of Atorvastatin when co-administered with bile acid binding resins. There is an increased risk of muscle damage such as rhabdomyolysis or nephrosis leading to renal failure when Atorvastatin is co-administered with HCV and HIV drugs. Caution should be exercised when co-administering Atorvastatin with Ritonavir + Lopinavir. Do not use Atorvastatin in combination with Fosamprenavir, Amiodarone, Saquinavir + Ritonavir, Nelfinavir, ... The above is important information about the use of Simvasboston 10 if there is any problem that requires further advice, the patient should contact the doctor. for in-depth advice.