Uses of Uphadol

Upahadol extra is a non-steroidal anti-inflammatory, antipyretic, analgesic. The drug is prepared in the form of long tablets, including 2 main ingredients: Paracetamol and caffeine. Patients can follow the article below to know what Uphadol extra is used for?

Ingredients contained in 1 tablet of Uphadol extra are:
Paracetamol 500mg. Caffeine 65mg. Excipients 1 capsule.

Uses of Uphadolextra:
Paracetamol activity has analgesic and antipyretic effects in people with high fever. However, the drug has almost no effect on normal body temperature. In addition, Paracetamol also acts on the hypothalamus to cause vasodilation, increase peripheral blood flow, so the drug has a good hypothermic effect. The caffeine component when combined with Paracetamol creates a synergistic effect and increases the pain-relieving effect. Uphadol Extra is used in the following cases:
Mild to moderate pain such as sore throat, migraine, tooth extraction, arthritis, headache, menstrual pain, musculoskeletal pain, toothache, .. . Fever. In addition, Uphadol Extra is also effective in the short-term symptomatic treatment of acute exacerbations of the following conditions: acute shoulder pain, tendonitis, low back pain and severe or traumatic nerve root pain.

Reference dosage of Uphadol extra is as follows:
Adults and children 12 years of age and older: Take 1-2 tablets/time, at least every 4-6 hours as needed. How to use:
Uphadol extra is not affected by food, so it is best to take with a meal with a glass of water. Tablets should be swallowed whole and should not be chewed.

Absolute contraindications of Uphadol extra include:
Cases of hypersensitivity or allergy to Paracetamol or to caffeine and other excipients. The case of peptic ulcer disease is progressing. Patients with liver failure and severe renal failure. In the case of children under 15 years of age. Cases of pregnant women in the first and third months of pregnancy or women who are breastfeeding. Relative contraindications: People who are being treated with non-steroidal anti-inflammatory drugs (NSAIDs), oral anticoagulants heparin or hypoglycemic sulfonamides, lithium salts and ticlopidine.

Non-steroidal anti-inflammatory drugs, high doses of salicylate when used simultaneously with Uphadol extra will increase the possibility of causing stomach ulcers and gastrointestinal bleeding. Oral anticoagulants, injectable heparin and ticlopidine when combined with Uphadol extra will increase the risk of gastrointestinal bleeding due to inhibition of platelet function and damage to the gastric mucosa - duodenum. With Lithium when used concurrently with the drug Uphadol extra will increase Lithium in the blood. Methotrexate used in combination with Uphadol extra increases the hematological toxicity of this substance. Hypoglycaemic sulphonamides concomitantly with uphadol extra will increase the hypoglycaemic effect. Digoxin when combined with Uphadol extra increases the concentration of digoxin in the blood. Antihypertensive drugs (ACE inhibitors and beta-blockers, diuretics): Decreased effect of these drugs by inhibition of vasodilator prostaglandins. Leflunomide, Teriflunomide, and Uphadol Extra have been reported to increase the risk of hepatotoxicity, including elevation of hepatic transaminases, cholestatic jaundice, hepatitis, hepatic necrosis, and acute liver failure. Lomitapide, Mipomersen used in combination with Uphadol extra increased serum transaminases and hepatic steatosis. Pexidartinib with Uphadol extra : Causes serious liver toxicity, even life-threatening. Prilocaine with Uphadol extra: Increases the risk of Methemoglobinemia, resulting in a decrease in the oxygen carrying capacity of the blood causing hypoxia in some tissues and organs. Phenothiazines and antipyretic therapy used in combination with Uphadol extra potentiate the severe antipyretic effect. Anticonvulsants (Phenytoin, Barbiturates, Carbamazepine) used together with Uphadol increase hepatotoxicity. Drinking alcohol while taking Uphadol Extra increases the risk of side effects on the liver. Note that it is possible that the reports of drug interactions above have not been fully covered. Therefore, to avoid interactions, you need to inform your doctor about the drugs or supplements you are taking, do not arbitrarily combine with other drugs without a doctor's prescription.

In the course of taking the drug, the following undesirable effects may occur:
Undesirable symptoms when using Uphadol extra are common such as: Gastro-intestinal disorders (nausea, vomiting, pain). stomach, indigestion and intestinal motility disorders). Uncommon side effects when using Uphadol extra such as headache, dizziness, erythema, itching, lumpiness and edema, decrease in platelet count, neutrophils, pancytopenia, fatigue, restlessness, anxiety, insomnia. If you experience these unwanted symptoms, the patient should stop using Uphadol extra and notify the doctor for appropriate treatment.

When taking an overdose of Uphadol, patients may experience symptoms including: dizziness, fatigue, nausea, vomiting, diarrhea, rash and allergies, increased Transaminase, Bilirubin, increased risk of necrosis liver cells, even causing death. In case of strong reaction, the patient may be shocked, comatose. Closely monitor patients who have overdosed on drugs and their manifestations, if suspected poisoning, take the patient immediately to the nearest medical facility for examination, monitoring and timely treatment.

During the course of taking Uphadol extra if you miss a dose, do the following: Take the dose again as soon as possible and skip it if it is too close to the next dose. Continue to take the next dose as usual, never take a double dose to make up for the forgotten portion.
Note: Dosing interval of Uphadol extra should be every 4-6 hours. Except for the case that the doctor is only strict about the time of use, it is necessary to strictly follow the indications. Please take the correct dose or consult your doctor before deciding to take a medicine when you have missed a dose.
In summary, Uphadol extra is an antipyretic, analgesic, anti-inflammatory, treatment of fever or pain caused by diseases of arthritis, tendonitis, menstrual pain, low back pain,.... To ensure that the drug is used safely, at the right dose, according to the indications and to avoid other adverse interactions, the patient needs to follow the doctor's prescription. If you have any further questions about Uphadol extra, please consult your doctor/pharmacist for advice.