Uses of Uphalium

Uphalium M is an gastrointestinal drug, with the main ingredient Domperidon 10mg. Uphalium M is used in cases of vomiting and nausea. For more information about the drug Uphalium M, readers can refer to the article below.

Uphalium M drug has the main ingredient Domperidone (as Domperidone maleate) 10mg. The drug is made in the form of hard capsules, 1 box of 10 blisters x 10 tablets or 1 box of 100 hard capsules. The drug is manufactured at TW25 Pharmaceutical Joint Stock Company.
Domperidone is an anti-dopamine agent, with characteristics similar to Metoclopramide hydrochloride. Because the drug largely has no effect on dopamine receptors in brain cells, because 92-93% of domperidone is bound to plasma proteins and hardly crosses the blood-brain barrier, Uphalium M has no effect on nerves and mental.
Uphalium M has the effect of stimulating peristalsis of the gastrointestinal tract, increasing the tone of the cardiac sphincter and increasing the amplitude of the expansion of the pyloric sphincter after a meal, but the drug Uphalium M does not affect the excretion. secretions of the stomach. Uphalium M is used in the treatment of acute nausea and vomiting, including vomiting and nausea caused by some side effects when taking drugs in Parkinson's disease such as Levodopa, Brommocriptin.
Uphalium M, after entering the body, is metabolized in the liver and intestines; Absorbed from the gastrointestinal tract, peak plasma concentrations are reached after about 30 minutes. After that, the drug is excreted in feces and urine mainly in the form of metabolites (nearly 1/3 of an oral dose is excreted in the urine in 1 day, 2/3 in feces within 4 days).

Drug Uphalium M is used in the following cases: Treatment of symptoms of digestive disorders such as bloating, indigestion, belching, heartburn; vomiting and nausea due to causes.
For children, Uphalium M is used in cyclic vomiting, due to upper respiratory tract infections or being treated with anti-cancer drugs. For adults, this drug is used in chronic gastritis, reflux oesophagitis, gastric prolapse and in the treatment of patients after gastrectomy, patients taking drugs containing L-dopa or anticancer drugs. .

Do not use Uphalium M in cases of hypersensitivity to any ingredient of the drug. Do not use Uphalium M if you have the following conditions: Prolactin-secreting pituitary tumor; moderate and severe liver failure; severe renal failure requires caution; gastrointestinal bleeding or perforation, mechanical intestinal obstruction; Pregnant; electrolyte disturbances ; diseases of the heart or conduction of the heart. You should immediately inform your doctor about these conditions before deciding to use the drug. Do not use Uphalium M while taking the following drugs: Antiemetics that block neurokinin-1 receptors in the brain, drugs that prolong the QT interval, inhibitors of CYP3A4. Inform your doctor about the medications you are taking for the best advice.

How to use:
Swallow the tablet whole, drink with plenty of water. Food can slow down the absorption of the drug, so you should take it 30 minutes before a meal to increase its effectiveness. If you forget a dose of medicine, take it as soon as possible (the time allowed is 1-2 hours compared to the time prescribed by the doctor). If the missed dose is close to the time for your next dose, skip the missed dose and use the next dose as directed by your doctor. Note, do not double the prescribed dose. If you are not sure about taking the medicine you should consult your doctor for detailed instructions. Uphalium M is used as prescribed by a doctor or you can refer to the following recommended dose:
For vomiting and nausea of ​​all causes:
Dosage for adults is 10-20mg/time Use 2-3 times a day at least 4 hours apart. Children over 12 years old and over 35kg use Uphalium M dose 0.2 - 0.4mg/kg/time, take 2-3 times/day, use at least 4 hours apart. Do not arbitrarily use the drug for children under 12 years old and under 35kg without a doctor's prescription. Dosage of Uphalium M used in the treatment of indigestion:
Adults: 10-20mg, 3 times/day, take the drug before meals and in the evening.
Special cases:
Uphalium M does not require dose adjustment in patients with mild hepatic impairment. For patients with renal failure: Because the drug is metabolized and excreted by the kidneys, in case of renal failure, the time between 2 doses of Uphalium M should be separated and the number of doses should be reduced to 1-2 times/day; Adjust the dose to suit your kidney function. Note:
Do not use the drug for more than 1 week. The drug should be used at a low dose and for the shortest duration to effectively control nausea and vomiting. The manufacturer does not recommend the use of Uphalium M in the prevention of vomiting after surgery.

Drug Uphalium M can cause some unwanted effects such as:
Transient allergic reactions, itching, rash. Gastrointestinal discomfort such as thirst, dry mouth, diarrhea, abdominal cramps. Gynecomastia in men, breast tenderness, engorgement, milk flow. Headache, drowsiness, stress. If you have any of the above discomforts or experience other unusual symptoms, you should immediately notify your doctor for prompt assistance.

Inform your doctor about your medical history, allergies or resistant substances, existing diseases and medications you are taking. Some drugs that affect the therapeutic effect of Uphalium M or during use cause interactions with each other, including: CYP3A4 enzyme inhibitors, opioid analgesics, Muscarinic muscle relaxants, Ketoconazole, Lithium, drugs. antihistamines such as Cimetidine, Famotidine, Nizatidine or Ranitidine. There are no data on the safety of Uphalium M in humans, but animal studies have shown that the drug has the potential to cause birth defects, so it should not be used in pregnant women. The drug is excreted in human milk, so the benefits and risks should be weighed before using Uphalium M in a nursing woman. Uphalium M has not been reported to affect the ability to drive and use machines, so you can use it in these cases. In case of overdose, you may have unusual signs such as drowsiness, extrapyramidal syndrome, inability to identify directions. You need to immediately notify your doctor or go to the nearest medical facility for timely support and treatment, measures may include gastric lavage, activated charcoal, electrocardiogram monitoring, using drug use. In summary, Uphalium M is an gastrointestinal drug, used in the treatment of vomiting and nausea. To ensure safety for your health, you should not arbitrarily use the drug without consulting your doctor to avoid unwanted effects and possible drug interactions.