Uses of Vastec 35 MR

Vastec 35 MR is prepared in the form of film-coated tablets, with the main ingredient being trimetazidine dihydrochloride 35mg. This medication is used for the symptomatic treatment of stable angina.

Vastec drug belongs to the group of cardiovascular drugs, indicated for use in the following cases: Symptomatic treatment of stable angina pectoris, inadequately controlled, intolerant to other angina therapies.
Vastec's ingredient is trimetazidine. In patients with ischemic heart disease, trimetazidine acts as a metabolite, preserving intracellular high energy levels of phosphate in cardiomyocytes. Trimetazidine has anti-ischemic potential but no hemodynamic effects.
Vastec is contraindicated in the following cases:
Hypersensitivity to one of the active ingredients in the formula; Parkinson's patients or Parkinson's symptoms, tremor, restless legs syndrome, other movement disorders; Patients with severe renal impairment, with creatinine clearance < 30ml/min.

How to use: The drug is taken orally, with meals.
Usual dosage: 1 tablet Vastec 35MR/time, used 2 times/day. Thereafter, treatment efficacy should be assessed every 3 months, with trimetazidine discontinued if the patient does not respond to therapy.
Dosage for special subjects:
Patients with moderate renal impairment (creatinine clearance 30 - 60ml/min): Use 1 Vastec 35MR tablet every morning; Elderly patients: There may be a higher than normal level of sensitivity to trimetazidine (due to age-related decline in renal function). Therefore, caution should be exercised when calculating the dose of Vastec for the elderly; Children: The safety and effectiveness of trimetazidine have not been evaluated in patients under 18 years of age. There are currently no data on this patient population. *Note: The drug dosage mentioned above is for reference only. The specific dose of Vastec drug depends on the condition and the progression of the disease. The doctor will prescribe the right dose for each patient.
Overdose: Immediately notify the doctor and quickly take the patient to the nearest hospital.
Missed dose: If you miss a dose of Vastec, the patient should take it as soon as possible. If it is almost time for your next dose, skip the missed dose and take your next dose as scheduled.

When using Vastec, patients may experience unwanted side effects:
Common: Dizziness, headache, indigestion, diarrhea, abdominal pain, nausea, vomiting, body weakness , skin rash, hives; Rare: Tachycardia, palpitations, arterial hypotension, orthostatic hypotension, dizziness, falls,...; Frequency not known: Parkinson's symptoms (tremor, tardiness, hypertonia), gait instability, restless legs syndrome, dyskinesia, sleep disturbance (insomnia, somnolence), constipation, angioedema, acute systemic pus, thrombocytopenia, agranulocytosis, thrombocytopenic purpura, hepatitis,... When experiencing side effects of Vastec, patients should stop using it. medication, notify the doctor or go to the nearest medical facility for timely examination and treatment.

Before using Vastec, patients should be aware:
Trimetazidine can cause or worsen Parkinson's symptoms. Therefore, elderly patients need to be regularly checked and monitored during drug use. In case of suspected Parkinson's syndrome, the patient should be referred to a neurologist for examination; When experiencing movement disorders such as Parkinson's symptoms, tremors, restless legs syndrome, unsteady gait, ... patients need to stop using Vastec. These symptoms are rare, usually reversible after the patient stops taking the drug about 4 months. If symptoms persist after 4 months of discontinuation, the patient should be referred to a neurologist; Patients using Vastec may fall, unsteady gait, drop in blood pressure (especially in people who are taking antihypertensive drugs); Caution should be exercised when prescribing trimetazidine to patients with a high degree of sensitivity (people over 75 years of age, people with moderate renal impairment); Vastec does not treat the root cause of angina, is no longer indicated in the treatment of unstable angina or myocardial infarction before/during the first days of hospitalization; The drug can cause dizziness, drowsiness, so it may affect the ability to drive, use machines; It is best not to use Vastec during pregnancy and lactation. Drug Interactions: There is no known interaction between Vastec with other drugs. However, patients still need to carefully monitor their health when combining Vastec with one or more other drugs.
When using Vastec, the patient should absolutely follow all instructions of the doctor. In addition, patients also need to pay attention to the manifestations of the body after taking the drug, if there are any side effects, they should immediately notify the doctor for examination and timely intervention.
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