Uses of Zafenak 50mg

Zafenak 50mg belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) with the main ingredient being sodium diclofenac. The drug is prepared in the form of enteric-coated film-coated tablets, packaged in many different forms including boxes of 3 blisters, 6 blisters or 10 blisters x 10 tablets and bottles of 100 tablets or 250 tablets. Zafenak 50mg is a prescription drug, so patients need to understand its uses, strictly follow the indications and doses prescribed by the doctor.

The composition of the drug Zafenak 50mg includes: Diclofenac sodium: 50mg. Excipients: Corn starch, PVP, Lactose, magnesium stearate, black iron oxide, red iron oxide, yellow iron oxide, Avicel,... The active ingredient Diclofenac in Zafenak 50mg is a derivative of phenyltacelic acid, which is one of the active ingredients. pain reliever, reduce inflammation, reduce fever for patients. Diclofenac's mechanism of action through inhibition of the synthesis of inflammatory mediators such as prostaglandins, prostacyclin and thromboxane by inhibiting the COX enzyme, thereby inhibiting the inflammatory process to help patients reduce inflammation. , reduce pain and swelling. Diclofenac also has an effect on platelet aggregation and regulation of the lipoxygenase pathway. Zafenak medicine 50mg is indicated in cases of long-term inflammation and also symptomatic treatment in acute attacks including:
Juvenile rheumatoid arthritis. Ankylosing spondylitis . Acute pain due to swelling or trauma. Chronic pain in chronic arthritis, osteoarthritis. Primary dysmenorrhea. Pain relief in cancer patients.

Zafenak 50mg should not be used in patients with the following conditions:
Hypersensitivity to Diclofenac or any of its ingredients. History of allergy to aspirin or other drugs in the same class of non-steroidal anti-inflammatory drugs. Pathology of gastric and duodenal ulcers is progressing. Patients with a history or current asthma, bronchospasm, bleeding disorders. Severe liver, kidney, and cardiovascular disease. Congestive heart failure disease. Patients with hypovolemia due to renal failure with a glomerular filtration rate less than 30 ml/min, or due to diuretics. People who are taking coumarin anticoagulants. People with gum disease. People who are using contact lenses daily. To ensure the effectiveness and safety of taking the drug, before the doctor prescribes it, the patient should inform his/her medical history and allergies to be considered for using Zafenak 50mg.

Usage: The drug Zafenak 50mg is used orally. Patients take Zafenak 50mg tablets whole with half a glass of water and should not be crushed or chewed to ensure absorption. The drug is used with or after meals to reduce side effects on the gastrointestinal tract.
Dosage
Osteoarthritis: 50mg / time, take 2-3 times a day or 75mg / time, 2 times a day. Long-term treatment with a dose of 100mg/day, do not use higher doses. Rheumatoid arthritis: 50mg/time, 3-4 times a day or 75mg/time, twice a day. The maximum dose is 200mg/day. Long-term treatment at a dose of 100 mg/day or may be increased to 200 mg/day if necessary, however, do not exceed a dose of 200 mg/day. Joint damage: 50mg/time, twice a day or 100mg/time, taken once before going to bed. Juvenile polyarthritis: Children from 1 to 12 years old: 1-3mg/day, divided into 2-3 oral doses. Pain: Acute pain or primary dysmenorrhea: 50mg/time, 3 times a day Chronic pain or recurrent dysmenorrhea: Initial dose 100mg/day, maximum 200mg/day. The following days 50 mg / time, 3 times a day, up to 150 mg / day. Pain relief in cancer: 100mg / time, 2 times a day.

Some patients may experience unwanted side effects when taking Zafenak 50mg such as:
Digestive disorders. Common: Headache, restlessness, vomiting, nausea, diarrhea, epigastric pain, gastrointestinal ulceration, elevated liver enzymes, tinnitus Uncommon: erythema, urticaria, edema, allergic reaction to laryngospasm, hypotension, drowsiness, depression, anxiety, irritability, excitability, open vision, eye pain, double vision. Rare: liver dysfunction such as gallbladder contractility, jaundice, hepatitis, Stevens-Johnson syndrome, alopecia, aseptic meningitis or hematopoietic disorders with neutropenia, eosinophilia, cystitis, hematuria, acute renal failure. Before prescribing Zafenak 50mg to a patient, the doctor weighed the benefits and risks of side effects. However, some patients may still experience this during treatment. At this time, the patient needs to stop taking the drug immediately or notify the doctor for treatment instructions.

Zafenak should be used with caution in patients with a history of gastrointestinal ulceration, bleeding or perforation. Systemic lupus erythematosus or severe liver or kidney dysfunction. Edema, congestive heart failure, hypertension Experiencing acute infection Liver function should be monitored in people with a history of liver disease while using Zafenak 50mg Coagulation disorders, bleeding disorders Patients with visual disturbances should have their vision checked regularly. Caution should be exercised when driving and operating machinery because Zafenak 50mg may cause drowsiness, drowsiness, headache. Diclofenac in Zafenak 50mg inhibits uterine contractions in pregnant women and severe respiratory failure in neonates due to premature closure of the ductus arteriosus, especially when the drug is used in the third trimester of pregnancy. Diclofenac is rarely excreted in human milk, so it can be used in lactating women in case a non-steroidal anti-inflammatory drug is required.

Zafenak 50mg drug may interact if used concurrently with the following drugs:
Should not be combined:
Oral anticoagulants or Heparin: Risk of heavy bleeding. Diflunisal: Increased plasma concentrations of Diclofenac and decreased clearance of Diclofenac may result in severe gastrointestinal bleeding. Quinolone antibiotics: Diclofenac and other NSAIDs can increase central nervous system side effects or cause seizures. Aspirin or Glucocorticoid: Increases the extent of gastrointestinal damage and decreases the concentration of Diclofenac in the blood plasma. Lithium: Zafenak increases blood levels of Lithium to toxic levels. If concurrent use is required, the patient must be closely monitored to detect early signs of toxicity, and regularly check blood lithium levels. Digoxin: Zafenak 50mg increases blood levels of Digoxin and prolongs the half-life of Digoxin. Intrauterine IUD: May make it less effective at preventing pregnancy. The following drugs can be used during treatment with Zafenak 50mg, but the patient must be closely monitored:
Antihypertensive drugs such as beta-blockers, ACE inhibitors, AT1 receptor blockers. Antacids: Lowers blood levels of Diclofenac, but conversely can help reduce stomach irritation caused by Diclofenac. Diuretics: Zafenak and diuretics increase the risk of renal failure secondary to prostaglandin inhibition, thereby reducing blood flow to the kidneys. Cyclosporin: Risk of Cyclosporin toxicity if 2 drugs are used concurrently. The patient's renal function should be monitored regularly while receiving Zafenak 50mg. Probenecid: Double Diclofenac concentration leading to toxicity. Cimetidine: Slightly decreased serum Zafenak concentrations but did not affect the anti-inflammatory activity of the drug. In addition, concomitant use of Zafenak and Cimetidine may help protect the gastrointestinal tract from the harmful effects of Diclofenac contained in Zafenak 50mg. Above is the complete information about the drug Zafenak 50mg. To use the drug safely and effectively, patients need to consult their doctor and strictly follow the instructions and dosage during treatment.