Uses of Zentocor 40mg

Zentocor 40mg is usually indicated to treat the following cases:
Primary dyslipidemia (type III); Adjunctive treatment with other lipid-lowering regimens to reduce total cholesterol, apolipoprotein B, triglycerides and LDL index in patients with hypercholesterolemia, supporting type IV hypotriglyceridemia.

Zentocor 40mg is used with a starting dose of 10mg / day, once a day. The maximum dose is 80mg / day, the drug can be taken at any time of the day, regardless of the meal.
Zentocor can be used in combination with Resin to increase the effectiveness of treatment. For patients with renal impairment, no dose adjustment is required.

In general, Atorvastatin is well tolerated, and side effects, if any, are usually mild and transient. Some common side effects when taking Zentocor 40mg are:
Constipation; Flatulence, indigestion; Stomachache; Nausea and vomiting; Dizziness, headache; Insomnia; Tired. In case of overdose, treatment should be symptomatic and supportive as needed. Because Zentocor is strongly bound to plasma proteins, hemodialysis is not expected to significantly increase atorvastatin clearance.

Contraindications to use Zentocor 40mg in the following cases:
Hypersensitivity to statins that inhibit HMG-CoA reductase; Patients with advanced liver disease or unexplained persistent elevations in serum transaminases; Pregnant and lactating women. In patients who drink heavily or have a history of liver disease, liver function should be checked during treatment with this drug. Patients should be re-examined for unexplained muscle pain, tension, or weakness, or with fever or fatigue.
In this population, liver enzyme testing should be performed prior to treatment with atorvastatin and in cases of clinical indications requiring subsequent testing.

Some notes when taking Zentocor with other drugs:
In combination with anticoagulants, Indandione may increase bleeding time or prothrombin time (PT). Therefore, it is necessary to monitor prothrombin time in patients receiving these two drugs in combination; Combination with drugs Gemfibrozil, Cyclosporine, Erythromycin, fibric acid derivatives, Niacin, Azole antifungals and immunosuppressants may increase the risk of muscle damage, more serious, rhabdomyolysis. Co-administration of Digoxin with Zentocor may cause a slight increase in the concentration of Digoxin in the blood; Avoid taking atorvastatin when taking Tipranavir with Ritonavir, Telaprevir; Use with caution and, if necessary, use the lowest dose of atorvastatin when used with the following drugs: Ritonavir and Lopinavir; Do not exceed 20mg Zentocor /day when used with the following drugs: Saquinavir + Ritonavir, Darunavir + Ritonavir, Fosamprenavir, Fosamprenavir + Ritonavir; Do not exceed 40mg of Zentocor/day when used with Nelfinavir. The above are the uses and special notes when using Zentocor 40mg. For more details and the correct use, patients should consult their doctor, pharmacist before taking the drug.
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