Uses of Zyloric

Zyloric is indicated in the treatment of:
Reducing urate/uric acid formation in diseases that cause urate/uric acid deposition (such as kidney stones, gouty arthritis, urate stones in the skin) or the risk of predicting predictable (eg, treatment for malignancies that can lead to acute uric acid nephropathy). Treatment of 2,8-dihydroxy adenin-associated kidney stones due to deficiency of adenin phosphoribosyltransferase activity. Treatment of recurrent mixed calcium oxalate nephrolithiasis seen in hyperuricemia when diet and other therapeutic measures have failed.

Zyloric is contraindicated in the following cases:
Patients with hypersensitivity to allopurinol or any of its ingredients. Patients with severe liver and kidney disease (hyperuremia). Patients with idiopathic hemochromatosis. Do not use the drug in the initial treatment of acute gout attacks. Children except those with tumors or enzyme disorders.

The most common adverse reaction of Zyloric is skin rash. Symptoms are usually maculopapular or pruritic, sometimes purpura, with more serious hypersensitivity reactions such as exfoliative rash, toxic epidermal necrolysis and Stevens-Johnson syndrome. Therefore, it is recommended to stop taking the drug as soon as signs of rash appear.
These hypersensitivity reactions can be severe or even fatal, especially in patients with liver or kidney failure. Hepatotoxicity and changes in liver function may also be seen in patients who do not exhibit hypersensitivity.
The drug can also cause hematological effects such as agranulocytosis, thrombocytopenia, aplastic anemia and hemolytic anemia. Some other rare side effects of the drug include paresthesia, gynecomastia, peripheral neuropathy, hair loss, taste disturbances, increased blood pressure, nausea, vomiting, abdominal pain, and diarrhea. bleeding, headache, dizziness, vertigo, visual disturbances.
There may be an increase in acute gout attacks when treatment with the drug is started, although these attacks usually subside after many months.

Pregnant women: There is no adequate evidence for the safety of the drug in pregnant women, although the drug has been used for many years without any obvious adverse effects. Use in pregnant women only when there is no safer alternative and if the disease presents a risk to the mother or fetus. Lactation: Allopurinol is excreted in human milk. However, the effects of allopurinol on breastfed infants have not been studied. Ability to drive and operate machines: The drug has some side effects such as drowsiness, dizziness and ataxia, patients taking the drug should be cautious before driving or operating machinery.

Zyloric is taken orally and taken after meals. The daily dose should not exceed 300 mg and may be divided into appropriate doses if the patient presents with gastrointestinal intolerance.
Adults: a dose as low as 100 mg/day should be used to reduce the risk of adverse drug reactions and increase the dose only when the serum uric acid response is inadequate. Elderly: In the absence of specific data, the lowest dose that adequately reduces urate should be used. Zyloric contains Allopurinol as the active ingredient. The drug is used in the treatment of reducing uric acid formation in diseases that cause uric acid deposition such as kidney stones, gouty arthritis. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
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