What does Valiera do?

Valiera drug has a compound composition including Estradiol 2mg along with other excipients and is made in the form of film-coated tablets. It is effective in the treatment of moderate to severe vasomotor symptoms associated with menopause, vulvar and vaginal atrophy.

Valiera drug includes the ingredient Estradiol, which is classified as the most powerful estrogen hormone in nature. Estradiol and other estrogen hormones in the body have an important role in the development and maintenance of the reproductive system as well as sexual characteristics of a woman. In postmenopausal women, estradiol stops secreting causing vasomotor imbalance as well as temperature regulation, which in turn causes hot flashes, sleep disturbances, excessive sweating and genital atrophy occurs.
Estradiol replacement therapy may help relieve symptoms of estradiol deficiency in postmenopausal women. Most women at this stage often show signs of gradual increase in bone loss due to estradiol deficiency. At that time, the bones become thin, weak and at high risk of fracture, especially in the vertebrae or hip and wrist bones. Signs of osteoporosis in women are also important indications in treatment with estradiol and this therapy is quite effective in reducing bone resorption. Estrogen is used as a supplement in the prevention of osteoporosis but cannot help the bone to restore the lost parts.
When Valiera enters the body, the Estradiol component will be well absorbed through the skin, mucous membranes and gastrointestinal tract. The drug is also widely distributed in the body and in high concentrations in sex hormone target organs. In the blood, estradiol is about 60% bound to albumin (38% of globulin is bound to sex hormones and about 2% is free). The metabolism of estradiol can be mainly concentrated in the liver and converted to estrone, estriol or other conjugates such as glucuronic or sulfate, glucuronic in the liver.

Valiera is effective in the treatment of moderate to severe vasomotor symptoms associated with menopause. However, there is currently no concrete evidence that estrogens will affect neurological symptoms or depression - considered one of the signs of menopause. Therefore, do not use Valiera in these cases.
In addition, the drug Valiera thickens the uterine lining, which is effective in the treatment of vulvar and vaginal atrophy. In addition, the drug also helps to treat cases of decreased estrogen secretion due to hypogonadism, ovariectomy. Treatment of prostate cancer can progress depending on androgen levels, so drugs should only be used temporarily.
Valiera can be used to prevent osteoporosis for women, especially women who are about to enter menopause. However, should Valiera be taken during pregnancy? Accordingly, Valiera should not be used in cases of pregnancy or suspected pregnancy or those in the following cases:
Abnormal vaginal bleeding, suspected or diagnosed breast cancer, cervical cancer. ... Valiera should not be used in cases of advanced thrombophlebitis or thromboembolism. Patients with liver, kidney, heart disease.

Valiera used in the treatment of moderate to severe vasomotor symptoms or atrophy of the vulva and vagina in menopause should use the lowest therapeutic dose, can choose additional symptomatic treatment regimen and then stop using the drug as soon as possible. Depending on the time interval from 3 to 6 months to stop or reduce the dose of Valiera drug.
The usual starting dose is 1⁄2 tablets to 1 Valiera tablet with a strength of 2mg per day. Depending on the level of symptom control of the patient will have a specific dose. The minimum effective maintenance dose of Valiera should be determined by slowly increasing titration until a therapeutic effect is achieved and using this dose for maintenance. Use of Valiera is also calculated according to the cycle, such as taking 3 weeks and stopping for 1 week.
Use of Valiera in the treatment of women with decreased estrogen secretion due to hypogonadism or oophorectomy and primary ovarian insufficiency. The starting dose used in these cases is usually 1⁄2 tablets to 1 Valiera tablet, depending on the degree of symptom control in the particular patient. The minimum effective maintenance dose should also be determined by titration.
Valiera drug treatment for cases of advanced androgen-dependent prostate carcinoma, the recommended dose is 1⁄2 tablets to 1 Valiera tablet, used 3 times a day. The effectiveness of the treatment regimen for this case should be assessed by measuring phosphatase along with the improvement of the patient's symptoms.
For the prevention of osteoporosis in women, the 2mg dose should be started as soon as possible after menopause and used as soon as possible. Patients should use the drug in a cycle, that is, taking it for 23 days and stopping for 5 days. Dosage may be adjusted to suit the patient's symptom control. If the natural rate of bone loss can be repeated, estrogen replacement therapy should be discontinued.

Valiera drug can cause side effects for some subjects when performing estrogen replacement therapy such as:
Menstrual disorders, increased size of uterine myoma or vaginal candidiasis... Some symptoms related to digestion such as nausea, vomiting, abdominal cramps, cholestatic jaundice, increased risk of gallbladder disease... Tanned skin or appearance of age spots, condition This persists even after discontinuation of the drug. Increased curvature of the cornea affecting vision or contact lens intolerance. Headaches or migraines, dizziness, and possibly even seizures.

Valiera drug should especially be considered when used for cases of breast cancer or can stimulate the creation of malignant tumors, people with diseases related to gallbladder, cardiovascular, hypertension, hypercalcemia ...
Drug interactions:
Concomitant use of 2 drugs containing estrogen and glucocorticoids may affect their metabolism in the body, such as prolonged half-life, effects therapeutic effects as well as drug toxicity may increase. Valiera may increase the levels of thyroid-binding globulin leading to an increase in circulating thyroid hormones. Valiera together with plasma protein binding agents may increase the concentration of corticosteroids and steroid sex hormones. Valiera increases plasma concentrations of HDL and the HDL2 cholesterol fraction or decreases LDL cholesterol concentrations. Valiera may cause impaired glucose tolerance. Valiera is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, vulvar and vaginal atrophy. The drug can cause side effects, so patients need to use it under the guidance of the treating doctor.