What is No Spa Forte?

No spa forte is an antispasmodic, used to treat spasms of smooth muscles in the digestive system, biliary tract disease or urinary tract disease. Before using the drug, you need to discuss carefully with your doctor about the benefits and risks that the drug brings to make an appropriate decision.

Nospaforte is a class of antispasmodic drugs, used mainly to treat smooth muscle spasms in biliary tract diseases (eg, bile duct stones, gallstones, pericholangitis, inflammation of the gallbladder, inflammation of the bile ducts, and gallstones). gall bladder, pancreatitis or cholangitis). Nospaforte is also used for smooth muscle spasms caused by urinary tract conditions such as ureteral stones, kidney stones, cystitis, pyelonephritis, or pain caused by bladder spasms.
Not only that, Nospa 80mg medicine is also used to support the treatment of smooth muscle spasms in the digestive system (including gastritis, peptic ulcer, pyloric spasm, increased colon irritation or inflammatory bowel disease) as well as some gynecological conditions, such as dysmenorrhea in women.
No spa forte is a product of Chinoin Pharmaceutical & Chemical Works Private Co., Ltd, which is prepared in the form of tablets with a box of 2 blisters x 10 tablets. In each Nospaforte tablet contains the following main ingredients:
Main active ingredient: Drotaverine hydrochloride 80mg. Other excipients just enough for one tablet: Corn starch, povidone, lactose, talc and magnesium stearate.

The active ingredient drotaverine in Nospaforte is a derivative of isoquinoline, which has antispasmodic properties directly on smooth muscle. The mechanism of action of the drug is due to inhibition of Phosphodiesterase (PDE) IV, while increasing cAMP levels, leading to smooth muscle relaxation through inactivation of light chain myosin kinase (MLCK).
In fact, phosphodiesterase (PDE) IV plays an important role in the blockade of smooth muscle contraction. Thanks to its selective inhibitory action on PDE IV, Nospaforte is widely used in the treatment of hypermotility disorders and spasms of smooth muscle in the gastrointestinal tract.
According to experts, Nospaforte has the effect of increasing tissue circulation thanks to its ability to dilate blood vessels. It is also effective for any smooth muscle spasm that is due to nerve or muscle related causes. Not only that, the active ingredient drotaverine also affects the smooth muscle of the biliary tract, digestive system, vascular system and urogenital system.
Below are the pharmacokinetic effects of the active ingredient drotaverine in the drug full spa forte:
Absorption: The drug is rapidly and completely absorbed after administration by injection or orally. Peak plasma concentrations of drotaverine are reached within 45 to 60 minutes of oral administration. Distribution: Drotaverine has a plasma albumin binding level of up to 98%, with a small amount bound to beta-globulin and gamma. Metabolism: Approximately 65% ​​of drotaverine is metabolized unchanged in the systemic circulation and the remainder in the liver. Elimination: The biological half-life of the active ingredient drotaverine is within 8-10 hours. After 72 hours, the drug will no longer be in the body, is excreted about 30% in feces and 50% in urine.

3.1 Dosage of drug No spa forte In addition to understanding what Nospa 80mg is, the patient also needs to know the appropriate dosage of the drug for his or her condition. Below is the recommended dose of no spa forte by the doctor:
Usual Adult Dose: Take 1-3 tablets / day, divided into 2-3 times / day. Usual dose for children over 12 years old: Take 1-2 tablets / day, divided into 1-2 times / day. 3.2 How to use No spa forte No spa forte drug No spa forte is used orally. Patients can take the drug with water, avoid drinking alcohol or other stimulants because this can reduce the effect of the active ingredient in the drug. In addition, you also need to take the pill as a whole, avoiding chewing or crushing it.
3.3 What to do when taking an overdose or forgetting a dose No spa forte When forgetting a dose:
The patient should take the missed dose at the earliest time as soon as he remembers. Skip the missed dose if it is too close to the time for your next dose, and instead continue taking it as planned. Avoid taking a double dose of full spa forte. When taking an overdose of the drug:
Overdose symptoms: There have not been any reports of possible reactions when taking an overdose of no spa forte. In case of overdose of drotaverine and unusual manifestations, the patient should stop taking the drug and immediately go to a medical facility for treatment.

Nospaforte should not be used in the following cases:
People with a history of allergy to drotaverine or hypersensitivity to any of the excipients in the drug. Children under 12 years of age should not use nospaforte. People with heart failure, liver failure or severe kidney failure.

No spa forte medicine can lead to the following side effects for patients:
Headache, dizziness. Feeling nervous, feeling nauseous. Insomnia . Lower blood pressure. Constipation. Allergic symptoms such as itching, rash or hives. When any of the above side effects appear, you need to stop using the drug and notify your doctor for timely resolution.

Nospaforte when used together with Levodopa may reduce the effectiveness of anti-Parkinson's disease and worsen muscle spasticity and tremor. To prevent the risk of drug interactions, you should tell your doctor about all medications you are taking and any other medical conditions you have.

7.1 What precautions should be taken while using No spa forte? The following are the subjects that need special caution when using Nospa 80mg, including:
Patients with low blood pressure. People who are lactose intolerant should be careful when using the drug because it contains 104mg of lactose, which can easily cause symptoms of digestive disorders. Pregnant women need to talk to or consult their doctor before taking Nospaforte. Women who are breast-feeding should not take no spa forte without a doctor's approval. People who often work in environments that require high concentration such as driving or operating machinery should be careful when using no spa forte because the drug can cause dizziness side effects. 7.2 How should No spa forte be stored? Nospaforte drug should be stored at a temperature < 30 degrees C, away from direct light. In addition, you also need to keep the medicine in its original packaging and place it in a cool, dry place, out of sight and reach of small children.
When the drug has expired on the package, you absolutely do not continue to take the medicine. However, it is necessary to avoid disposing of spoiled medicines through household waste or sewage systems to protect the environment, and instead refer to the disposal of expired medicines according to the advice of your doctor.