When is Atosiban used for preterm labor? Things need to notice

To prevent preterm birth, delaying preterm labor will allow the fetus to be nourished in the mother's womb for as long as possible. One of the methods used is the anti-premature drug Atosiban. So when to use Atosiban and what should be noted?

When born prematurely, babies will face many dangers such as infections, poor adaptability to the environment outside the womb due to their immature bodies and this is also the main cause of death in newborns. born.
Preterm labor is when regular uterine contractions accompanied by changes in the cervix occur before 37 weeks of pregnancy. This is considered a complication of pregnancy, because in addition to the risk of perinatal death in extremely preterm infants, premature babies also face dangerous complications such as intraventricular hemorrhage, respiratory distress syndrome, etc. necrotizing enterocolitis, sepsis, cerebral palsy, and convulsions. Premature birth rate accounts for 11-12% of live births.
It is because of the above serious consequences that doctors and pregnant women must pay attention to recognize the risk factors and symptoms of preterm labor.

2.1. Risk factors for preterm birth pregnant women need to know Pregnant women with a history of preterm birth Pregnant women with regular uterine contractions Premature rupture of membranes Pregnant women with congenitally weak cervix due to cleft palate or cervix short or secondary to cones, dilation and curettage of the cervix.

Pregnant women with infections such as: bacterial vaginosis, amniotic fluid infection, urinary tract infection Uterus is excessively enlarged due to polyhydramnios, multiple pregnancy Pregnant women have abnormalities in the uterus such as: uterine fibroids, double uterus , the uterus has a septum. Placental abnormalities: placenta previa, placental abruption. Smoking pregnant women: this is associated with premature rupture of membranes.

2.2. Preterm labor symptoms you need to know Pregnant mother has menstrual-like abdominal pain Pregnant mother has dull back pain Feeling of tightness in the abdomen and pelvis Pregnant woman has abdominal cramps like diarrhea but with or without with diarrhea Changes in vaginal discharge such as more, watery mucus or blood The uterus may contract but is usually painless. When pregnant women have risk factors or see the above symptoms, they should quickly notify the obstetrician for timely treatment. There are now many ways to prevent and treat preterm birth, one of which is the anti-premature drug Atosiban.

Atosiban is an inhibitor of the hormones vasopressin and oxytocin. Atosiban is used to delay impending preterm birth in pregnant women with the following symptoms:
Regular uterine contractions lasting at least 30 seconds with frequency ≥ 4 contractions/30 minutes Cervical uterus dilated from 1 to 3cm (0-3cm for women who have not given birth) Cervical removal ≥ 50% Maternal age ≥ 18 years gestational age 24 - 33 weeks full fetal heart rate normal . Atosiban is contraindicated in the following cases:
Gestational age < 24 weeks or > 33 weeks The water breaks prematurely over 30 weeks of pregnancy Abnormal fetal heartbeat Pregnant woman has uterine bleeding before delivery, need to deliver immediately In case a woman has severe eclampsia and pre-eclampsia requiring immediate delivery, stillbirth, pregnant woman suspected of having a uterine infection, placenta previa, placental abruption Or other signs of the mother or fetus that make it difficult to pull Long-term pregnancy will be dangerous.

Atosiban is an anti-premature medication that effectively slows the progression of preterm labor for 7 days, has less dangerous side effects than other drugs and the frequency of side effects is also less common. Therefore, until now, Atosiban is recommended by the Royal Society of Obstetricians and Gynecologists for the treatment of uterine contractions. While nifedipine (another drug also used in the treatment of preterm birth) is contraindicated in patients with diabetes, concomitant cardiovascular disease, or multiple pregnancies, Atosiban is the preferred choice. suitable for mound reduction suitable for these subjects. Because of the above advantages, Atosiban seems to be considered as one of the safe options for the treatment of threatened preterm birth.

However, when using Atosiban, you still need to keep a few things in mind:
Atosiban is an anti-preterm birth medication, so it is only used when it has been diagnosed that there is a risk of preterm birth at 24 to 24 weeks. 33 of pregnancy During pregnancy, pregnant women who are also breastfeeding should stop breastfeeding during the period of taking Atosiban. Because breastfeeding releases the hormone oxytocin which can further increase uterine contractions, which would counteract the effects of Atosiban In clinical trials, it was found that Atosiban did not affect the baby. dinking mother milk. However, small amounts of Atosiban have been shown to pass from plasma into breast milk. Atosiban is an anti-premature medicine used in the treatment of threatened preterm birth, helping the fetus to develop best in the womb. However, the use of the drug must be in accordance with the instructions of the obstetrician-gynecologist, it is necessary to discuss with the treating doctor immediately if there is any doubt or unusual symptoms when using the drug.

The Maternity Package at Vinmec International General Hospital helps customers complete the antenatal check-ups and necessary tests during pregnancy, in order to minimize the risk of preterm birth. Customers registered for Maternity Package are fully cared for and checked for health of mother and baby before birth - during childbirth and after birth.
Currently Vinmec has all-inclusive maternity packages including:
Maternity care program 2019 – Labor Maternity care program 2019 – 36 weeks Maternity care program 2019 – 27 weeks Pregnancy care program For the period of 2019 - 12 weeks, if you need advice and contact to register for an appointment, you can contact Vinmec Hospital and Clinic system HERE.