Dangers of nodal arteritis
1. What is nodular arteritis?
Nodular arteritis is a rare disease that can occur at any age, the rate is higher in people 50 - 60 years old, the male/female ratio is 2.5/1.
2. Causes of nodular arteritis
CECR1 gene mutations; HBV infection (present in 30% of cases), HCV, Varicella-zoster virus, parvovirus B-19,...; Infections: Tuberculosis, Klebsiella, Pseudomonas, Toxoplasma gondii,...; Taking drugs: Minocycline, Levamisole, Thiabendazole, hepatitis B vaccine,...
3. Symptoms of polyarteritis nodosa
3.1 Systemic symptoms Fever; Pale, tired people; Anorexia, weight loss. 3.2 Skin symptoms Skin symptoms are quite common, occurring in about 40% of patients with arteritis nodule. Characteristic manifestations include:
Nodules, mainly in the lower extremities, with lesions similar to erythema nodosum but smaller lumps; Ulcers: Usually occur on lumps, when healed without leaving skin atrophy; Liveoid network: These are blue-violet reticular patches on the skin, often distributed around the fat lobes, which are more obvious when experiencing cold, bleeding; If you have acute arteritis, you may have symptoms such as large inflammatory plaques, edema; Raynaud's syndrome, ischemia of the extremities, especially in the toes, causing gangrene; Skin lesions are often painful, mainly in the lower extremities. 3.3 Symptoms on other organs Joint pain, muscle pain, especially leg muscles; Central nervous system: Infarction, cerebral hemorrhage. May present late (2-3 years after vasculitis); Peripheral Nerves: Asymmetrical peripheral neuritis; Gastrointestinal: Atypical symptoms include abdominal pain, vomiting, gastrointestinal bleeding, hepatitis, cholecystitis, mesenteric infarction, intestinal perforation, pancreatitis,...; Kidney: Decreased kidney function, increased blood pressure; Testicular - ovary damage: Unilateral epididymitis; Cardiovascular: Chest pain, pericarditis, myocarditis, arrhythmia, myocardial infarction; Other manifestations: Blurred vision, signs of infarction / rupture of aneurysms in other organs.
4. Treatment of polyarteritis (PAN)
4.3 Long-term care for the patient Monitor blood counts, urinalysis, renal and liver function tests; Closely monitor infectious complications; Early detection of slow-onset cancers, especially in patients treated with cyclophosphamide; Maintain a low-salt diet if the patient has hypertension.
5. The danger of nodal arteritis
The disease may be localized to a single organ or progress to multiple organ failure. Complications of polyarteritis nodosa include renal failure, thrombosis of the involved vessels, tissue and organ necrosis, myocardial infarction, stroke, multifocal mononeuritis, and peripheral neuropathy. border, perforation of hollow viscera (intestine).
If left untreated, nodular arteritis has a poor prognosis. It is estimated that the 5-year survival rate of patients is only about 13%. If treated with steroids and cytotoxic drugs, the 5-year survival rate can be as high as 75-80%. Patient survival was improved with hepatitis B-associated polynoditis due to the introduction of antiretroviral regimens. Prognosis is poorer in patients with polyarteritis with proteinuria, renal failure, gastrointestinal tract lesions, central nervous system involvement, or cardiomyopathy.
Nodular arteritis is a dangerous disease with many unpredictable complications and a rather poor prognosis. Therefore, as soon as the warning symptoms appear, the patient should go to the hospital for examination, accurate diagnosis and timely and effective treatment plan.
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