What is Wilson's disease? Causes and symptoms
1. What is Wilson's disease?
When computed tomography or magnetic resonance imaging can show ventricular dilatation, cortical atrophy and density changes as well as other abnormal signs in the basal nuclei.
2. Causes of Wilson's disease
In Wilson's disease, part of the gene located on chromosome 13 is inactive, (ATP7B). The gene helps control the release of copper by liver cells into the bile. However, due to an inoperable gene error, copper accumulates in liver cells, when the amount of copper is exceeded, it spills into the blood and is deposited in other organs of the body (brain, eyes and other organs). other).
3. Symptoms of Wilson's disease
Neurological: Extrapyramidal diffuse extrapyramidal dystonia in facial muscles, vocal cords, neck and lumbar muscles; when the patient exerts himself, walks, speaks, and sometimes there may be contralateral spasms; immobilize face, mouth, pharynx; difficulty speaking, slow speed, monotonous sound, dysphonia; walking and when standing difficult; eye disorders, drooling, acne, vasomotor disorders; Seizures or strokes may occur. Psychiatric: Patients often have emotional and mood disorders. Many cases of intellectual impairment tend to progress to mental decline, psychosis. Pigmentation disorders: The eyes appear green-brown Kayser - Fleischer rings, around the cornea at the posterior surface of Descemet's membrane. Copper can be deposited in the sclera and vitreous causing a sunflower-shaped cataract; light brown or light gray skin color. Digestive disorders: Loose stools with fever, vomiting, loss of appetite, abdominal pain, nosebleeds, bleeding gums, jaundice. Cirrhosis occurs with liver signs and then atrophy, portal hypertension, esophageal varices, and splenomegaly.
Để đặt lịch khám tại viện, Quý khách vui lòng bấm số HOTLINE hoặc đặt lịch trực tiếp TẠI ĐÂY. Tải và đặt lịch khám tự động trên ứng dụng MyVinmec để quản lý, theo dõi lịch và đặt hẹn mọi lúc mọi nơi ngay trên ứng dụng.