Uses of Atigluco

Glucosamine has many uses for damaged joints. Therefore, the drug is often used for the purpose of reducing the symptoms of mild to moderate arthritis. This active ingredient is found in Atigluco 500 and Atigluco 1500 products.

1. What is Atigluco 1500?

Atigluco 1500 is produced in sachets containing ivory-white and orange-flavored nuggets with ingredients including:
Main active ingredients: Glucosamine hydrochloride equivalent to Glucosamine 1500mg; Excipients: Mannitol, Lactose, PVP K30, Sucralose, Sodium benzoate, citric acid, orange flavor powder. Besides the content of 1500mg, Atigluco product also has another form of Atigluco 500, corresponding to Glucosamine 500mg. The packaging of Atigluco 1500 in each box includes 30 packs x 3 grams.
The active ingredient Glucosamine in Atigluco 1500 is an amino-monosaccharide and a raw material for the synthesis of Proteoglycan. When taken into the body, Glucosamine concentrates mainly in bones and joints with the effect of stimulating cartilage cells to produce Proteoglycan and Collagen. Active ingredient Glucosamine simultaneously inhibits enzymes that destroy joint cartilage such as Collagenase, Phospholinase A2 and reduces superoxide free radicals that destroy cartilage cells. In addition, the drug Atigluco 1500 also has other effects such as:
Stimulates the production of bone connective tissue; Limit the processes of calcium loss in bones; Increased production of synovial mucus increases the viscosity and lubricating capacity of synovial fluid.

2. Indications and contraindications of Atigluco 1500

Atigluco 1500 is indicated for patients who need to relieve the symptoms of mild and moderate knee arthritis.
However, Atigluco 1500 is contraindicated in the following cases:
Patients with hypersensitivity to Glucosamine and excipients contained in the product; Atigluco 1500 should not be used in patients with pulmonary tuberculosis; Children under 18 years old, pregnant and lactating patients are not allowed to use Atigluco 1500; In addition, patients with intolerance to sulfur groups should not use Atigluco 1500.

3. Dosage, how to use Glucosamine

Atigluco products are prepared in sachets for oral use. Patients should take the drug with meals with a dosage of 1 pack of Atigluco 1500 or 3 packs of Atigluco 500. Drink 1 time / day for a minimum of about 2-3 months.
There are no special studies on the use of Atigluco in patients with hepatic or renal impairment. The pharmacokinetic and toxicological characteristics of Glucosamine have not shown limitations when used in these subjects, however, the use of Atigluco 1500 in patients with severe hepatic and renal impairment should be strictly controlled.
Due to the existence of some side effects when using Atigluco 1500 for elderly patients, treatment should be maintained at the lowest effective dose. Another advantage of Atigluco 1500 is that it can be used for a long time without causing gastric dysfunction.
After the treatment period, the patient may be considered to repeat the course of Atigluco after 6 months (or earlier) depending on the doctor's instructions.
Patients overdosing Atigluco 1500 often have unusual manifestations such as headache, dizziness, disorientation, joint pain, nausea, vomiting, diarrhea or constipation... Management of Glucosamine overdose includes Discontinue the drug, then treat symptomatically and supportively.

4. Side effects of Atigluco 1500

Side effects of Atigluco 1500 have been reported in only a small number of patients. Along with that, the side effects only occur temporarily at mild level with the frequency encountered as follows:
Common side effects of Atigluco 1500 include gastrointestinal disturbances (such as abdominal pain, bloating, dyspepsia, indigestion). , nausea, constipation or diarrhea), nervous system disorders (such as headache, somnolence, fatigue); Uncommon side effects of Atigluco 1500 include skin and subcutaneous tissue disorders (such as erythema, pruritus, or rash); Some adverse effects of Atigluco of unknown frequency: Allergic reactions, dizziness, vision disturbances and hair loss.

5. Be careful when using Atigluco 1500

When taking Atigluco 1500 for the treatment of chronic conditions, the following possibilities should be considered:
Patients on long-term treatment with Atigluco 1500 should have periodic tests such as a complete urinalysis, blood counts or liver and kidney function tests; In some cases, it is not appropriate to use Atigluco 1500, so other more suitable therapy should be considered. When using Atigluco 1500 to treat acute diseases, the following issues should be noted:
Monitor the patient closely in case of acute arthritis. The effects of Atigluco 1500 on the ability to drive and use machines have not been observed. However, it is recommended that this subject should use Atigluco 1500 with caution because of the possibility of adverse effects such as headache, somnolence, fatigue, dizziness or vision disturbances... and may affect the drive or operate machinery.

6. Drug interactions of Atigluco 1500

Glucosamine can increase insulin resistance and affect glucose tolerance, therefore caution should be exercised when administering Atigluco 1500 to patients with diabetes. There have been reports that the anticoagulant effect of Coumarin is increased when co-administered with Atigluco 1500. Therefore, this group of patients should be closely monitored for coagulation tests when starting or ending treatment with Atigluco 1500. Atigluco 1500 may interact to increase the absorption of tetracycline antibiotics in the gastrointestinal tract. Steroid or non-steroidal anti-inflammatory drugs or analgesics can be treated with Atigluco 1500.

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