Uses of Herazole

Herazole medicine has the main ingredient fluconazole 150mg with other excipients: Lactose monohydrate 200, sodium lauryl sulfate, povidone K30, anhydrous colloidal silicon K200, magnesium stearate. Herazole drug is manufactured by Hera Biopharmaceutical Co., Ltd., circulated in our country with the registration number VD-33952-19. Herazole is prepared in the form of hard capsules, each box includes a box of 1 blister x 1 tablet.
Pharmacodynamics:
The component of Fluconazole in Herazole is a triazole antifungal agent, which acts mainly by inhibiting the cytochrome P450-mediated demethylation of 14 alpha-lanosterol in the fungus. This is an essential step for ergosterol synthesis.
Pharmacokinetics:
Absorption: Fluconazole is well absorbed orally and is not affected by food. Peak plasma concentrations are reached after approximately 1-2 hours of dosing.
Distribution: Fluconazole is widely distributed in body tissues and fluids.
Elimination: The half-life of fluconazole is approximately 30 hours.

Herazole is indicated for the treatment of the following cases:
Cryptococcal meningitis. Vaginal candidiasis. Candida infections of the oropharynx, esophagus, urinary tract, peritoneum and other serious systemic candidal infections such as candidaemia, pulmonary, disseminated candidiasis. Fungal diseases caused by Blastomyces, Coccidioides and Histoplasma. Prophylactic treatment:
Prophylaxis of Candida infections for immunocompromised patients, cancer patients, bone marrow transplant patients undergoing chemotherapy or radiation therapy or AIDS.

3.1. Dosage The dose of Herazole and the duration of treatment will depend on the type of fungus causing the disease, kidney function as well as the patient's response to the drug. During the treatment of fungal diseases, it is necessary to use the drug continuously until the clinical and laboratory manifestations prove that the disease is completely cured. The disease is likely to recur if treatment is not given enough time.
For patients with cryptococcal meningitis and HIV infection, long-term maintenance therapy with Herazole is required to prevent recurrence.
For infants:
2 weeks after birth: 3-6 mg/kg/time; every 72 hours. 2-4 weeks postpartum: 3-6 mg/kg/time; every 48 hours. For children:
Prophylaxis: 3 mg/kg/day for superficial fungal infections and 6-12 mg/kg/day for systemic fungal infections. Treatment: 6 mg/kg/day. In cases of persistent disease, up to 12 mg/kg/24 hours may be required in 2 divided doses. Do not use more than 600 mg per day. For adults:
Vaginal candidiasis: Use a single dose of 1 tablet (150mg)/time/day. To prevent recurrence, a dose of 1 tablet (150mg) should be used once a month for a period of 4-12 months. Oropharyngeal candidiasis: The recommended dose is 1 tablet (150mg) once daily, for 1 to 2 weeks Oesophageal candidiasis: Take 1 tablet (150mg) once daily for at least 3 consecutive weeks. and at least 2 more weeks after the symptoms are gone. Systemic candidiasis: Take 3 tablets on the first day, and then take 1 tablet (150mg) once a day on the first day, for at least 4 weeks and at least 2 more weeks after the symptoms are gone. Cryptococcal meningitis: 3 tablets/time on the first day, 1-3 tablets/time/day in the following days, using the drug at least 6-8 weeks after CSF culture results are negative. For HIV-infected patients, Difuzit should be used at a dose of 1 tablet once a day for a long time to avoid relapse. Prophylaxis of fungal infections: To prevent Candida infections in bone marrow transplant recipients, the recommended dose is 3 tablets (450mg)/time/day. For patients predicted to have severe granulocytopenia (neutrophil count less than 500/mm3), prophylactic fluconazole should be started a few days before neutropenia and continued for another 7 days. after the neutrophil count has exceeded 1000/mm3. For patients with renal impairment:
Creatinine clearance > 50 ml/min: 100% of the recommended dose Creatinine clearance < 50 or = 50 ml/min: 50% of the recommended dose Routine hemodialysis: 100% of the dose recommended after each hemodialysis 3.2. Treatment of missed dose, overdose Overdose:
In case of using Herazole drug in excess of prescribed and having abnormal symptoms, it is necessary to immediately contact the nearest medical facility. In addition, family members should also bring any medications the patient has been using or medical records so that the doctor can treat them promptly.
Missed dose:
During the use of Herazole, patients need to adhere to the treatment schedule of the doctor, to avoid the occurrence of missed doses that reduce the effectiveness of treatment. If you miss a dose of Herazole, use the missed dose as soon as you remember. But if it is too close to the next dose, skip the missed dose and take the next dose as scheduled. Patients should not double the dose of Herazole, because it can cause an overdose. To overcome missed dose, patients can set an alarm or ask a loved one to remind them to take the right dose of Herazole.

During the use of Herazole medicine, you may experience some specific side effects as follows:
Common: Headache, dizziness, abdominal pain, nausea, vomiting, diarrhea,... Uncommon: Skin rash rash, rash,... Rare: Anemia, leukopenia, thrombocytopenia, exfoliative skin Stevens - Johnson syndrome, fever, edema, pleural effusion, hypotension, hypokalemia, shock defense,...

5.1. Contraindications The use of Herazole is contraindicated in cases of hypersensitivity to azole antifungals (miconazole, ketoconazole and clotrimazol) or to any of the ingredients of Herazole.
5.2. Precautions when using the drug During the use of Herazole, patients should pay attention to some of the following issues:
Caution when using Herazole in patients with impaired renal function and liver function impairment, arrhythmias or prolongation of the QT interval on the electrocardiogram. Since the safety of Herazole in pregnancy has not been established, the drug is not suitable for use in pregnant patients. Pregnant women should take fluconazole only when the potential benefit outweighs the potential risk to the fetus. The drug is contraindicated in nursing women because fluconazole is excreted in milk at concentrations similar to those in plasma. At therapeutic doses, Herazole may reduce the patient's ability to concentrate such as headache, dizziness. with jobs that require physical health and mental alertness such as operating machinery, driving. Therefore, caution should be exercised when Herazole is administered to a person driving or operating machinery. In the process of using Herazole, patients need to pay attention to follow the doctor's instructions, carefully read the notes before taking to be able to bring the most effective treatment, limit possible side effects. happen.