Uses of Novonazol

Novanazol is an antifungal drug, used orally in cases of fungal infections caused by fungi sensitive to Itraconazole. To use the drug safely and effectively, please refer to the information about Novonazol through the article below.

1. What are the effects of Novonazol?

Novonazol drug has the main ingredient Itraconazole 100mg, prepared in the form of soft capsules.
Itraconazole is an oral antifungal, triazole derivative, with a broad spectrum of antifungal activity. In vitro studies have confirmed that itraconazole exerts antifungal activity by interfering with fungal cell ergosterol synthesis. Ergosterol is an essential component of the cell membrane of fungi, the disruption of this synthesis inhibits the growth of fungi.
Intradazole-sensitive fungi include: Dermatophytes (strains of Trichophyton spp., Microsporum spp., Epidermophyton floccosum) yeasts (Candida strains including C. albicans, C. glabrata and C. krusei, Cryptococus neoformans, Pityrosporum) spp., strains of Trichosporon spp., Geotrichum spp., Aspergillus spp., Histoplasma spp., Paracoccidioides brasiliensis, Sporothrix schenekii, Fonsecaea spp., Claslosporium spp., Blastomyces dermatitidis, yeasts, Pseffeidallescheria other.

2. Indications and contraindications of Novonazol

Novonazol is indicated in the following cases:
Candidiasis in the mouth or throat. Ringworm, fungal infections of the skin such as tinea pedis, inguinal ringworm, body skin, interstitial skin. Toenail or nail fungus. Visceral fungal infections caused by fungi such as Aspergillus and Candida, Cryptococcus, Histoplasma, Sporothrix, Paracoccidioides, Blastomyces. Maintenance therapy: In patients with AIDS to prevent recurrent latent fungal infections. Prevention of the risk of fungal infections during prolonged neutropenia. Contraindications:
Do not use Novonazol in the following cases:
Patients with hypersensitivity to Itraconazole or its components. This drug should not be used in pregnant or lactating women, who should only use it when visceral fungal infection is life-threatening and when the potential benefit outweighs the risk to the fetus. . Concomitant use with drugs: Terfenadine, astermizol, cisapride, triazolam and oral midazolam is not indicated.

3. Dosage and how to use Novonazol

How to use: Should take the drug after eating, do not break the structure of the capsule before taking it.
Vaginal - vaginal candidiasis: Take 2 tablets (100mg) and 2 times a day for 1 day; or take 2 tablets x 1 time / day and use for 3 days. Ringworm: Take 2 tablets and once a day for 7 days. Ringworm: Take 2 tablets x 1 time/day for 7 days or take 1 tablet x 1 time/day for 15 days. For highly keratinized areas such as in the case of fungal infections on the soles of the feet and palms, take 2 tablets and 2 times / day for 7 days or 1 tablet and 1 time / day for 30 days. Candida infections in the mouth and throat: Take 1 tablet x 1 time/day for 15 days continuously. In patients with AIDS, organ transplant or neutropenia, take 2 tablets x 1 time / day for 15 days. Toenail fungus: Drink 2-3 times, 7 days each time, take 4 tablets divided into 2 times a day. Treatment sessions are always 3 weeks apart without medication. Or continuous treatment 2 tablets x 1 time / day for 3 months. Visceral fungal infections:
Aspergillus infections: Should take 2 tablets and 1 time / day, continuously for about 2-5 months, if the case of widespread disease can increase the dose of 2 tablets and take 2 times / day. Candida infection: Take 1-2 tablets once a day for 3 weeks to 7 months. Cryptococcus infections: Take 2 tablets and 1 time a day, continuously for 2 months to 1 year. Cryptococcal meningitis: Take 2 tablets x 2 times/day. Maintenance treatment take 2 tablets x 1 time / day. Histoplasma infection: Take 2 tablets and 1-2 times a day, the average duration of drug use is 8 months. Sporothrix schenckii infection: Take 1 tablet x 1 time/day, continuously for 3 months. Paracoccidioides brasiliensis infection: Take 1 tablet x 1 time/day, use for 6 months. Chromomycosis (Cladosporium, Fonsecaea): Take 1-2 tablets once a day for 6 months.

4. Side effects of the drug Novanazol

Some of the side effects you may experience while taking the drug include:
The most common side effects in clinical studies of gastrointestinal origin: Gastrointestinal disturbances causing nausea, diarrhea , abdominal pain, indigestion, flatulence. Very rare: Hypersensitivity and allergic reactions; Decreased blood potassium; Peripheral neuropathy , headache, dizziness; Congestive heart failure; Pulmonary edema; constipation; Hepatitis, reversible increase in liver enzymes; Stevens-Johnson syndrome, angioedema, urticaria, baldness, photosensitivity, rash, pruritus; Menstrual cycle disorder. When you experience side effects while taking the drug, you should notify your doctor for advice and treatment if necessary.

5. Things to keep in mind when taking Novonazol

Novonazol is a prescription drug that is only used under the direction of a doctor. Do not arbitrarily use or change the dose or duration of the drug.
In systemic candidiasis, if fluconazole-resistant Candida is suspected, the fungus may not be sensitive to Itraconazole. Therefore, before treatment should be tested for sensitivity to Itraconazole. Although short-term treatment does not affect liver function, this drug should not be used in patients with a history of liver disease or liver toxicity caused by other drugs. When long-term treatment means more than 30 days, periodic monitoring of liver function is required.
Itraconazole can harm an unborn baby, so effective birth control should be used to prevent pregnancy while using it and for at least 2 months after the last dose. If you are pregnant, tell your doctor right away for advice.
Very small amounts of Itraconazole may be excreted in breast milk. To be on the safe side, you should not breast-feed while taking this medicine.

6. Novonazol drug interactions

Some drugs that can cause interactions include:
Itraconazole when taken with warfarin can increase the anticoagulant effect of warfarin. Caution should be exercised when co-administering calcium channel blockers with Itraconazole because it may cause edema and tinnitus. In addition, Itraconazole may cause inhibition of the metabolism of calcium channel blockers, increasing the risk of congestive heart failure. Limit use in patients with congestive heart failure. With cholesterol-lowering drugs of the HMG - CoA reductase inhibitor group or statin group (lovastatin, atorvastatin, simvastatin, pravastatin...), Itraconazole can increase the concentration of these drugs in the blood, thereby increasing the risk of myositis. or muscle disease. Itraconazole increases plasma concentrations of digoxin when co-administered. Severe hypoglycaemia has been reported with oral antidiabetic agents concomitantly with azole antifungals. Above is information about the use, dosage and things you need to keep in mind when taking the drug. Watch for unusual signs while taking the drug, and notify your doctor when necessary.

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