Uses of Paparin
1. What is Paparin?
What is Paparin drug and how does Paparin work are frequently asked questions of users. Accordingly, the drug Paparin contains the main ingredient Papaverin - belonging to the group of Benzyl isoquinolin substances. This is the extract of the poppy plant, prepared as an injectable solution that inhibits smooth muscle contraction by inhibiting oxidative phosphorylation and inhibiting calcium channel causing inhibition of muscle contraction to increase cAMP. .
In addition to the ability to resist smooth muscle spasm, Paparin also has the effect of dilating the gastrointestinal tract and biliary tract, ureters, and myocardium.
2. Indications and contraindications
2.1. Indications With a direct inhibitory effect on smooth muscle spasms, Paparin is often prescribed by doctors in the following cases:
Patients with gastrointestinal smooth muscle spasms. People with signs of abdominal pain due to stomach and intestinal spasms. Bile duct spasm, renal colic. 2.2. Contraindications Paparin is contraindicated in the following cases:
Patients with complete atrioventricular block. People who are hypersensitive or allergic to Papaverin. Parkinson disease .
3. Usage and dosage of Paparin
Paparin is an injection drug that is used for subcutaneous, intramuscular, or slow intravenous injection. You can refer to the following dosage when taking the drug.
Adults: Use g Paparin with a dose of 30 to 120mg depending on the specific case. The next dose may be administered 3 to 4 hours later, either intramuscularly or intravenously. For children: Use Paparin at a dose of 4 to 6 mg/kg body weight every 24 hours and divided into 4 times, can be administered intramuscularly or intravenously. When using Paparin by injection, you need to pay attention to slow injection over a period of 2 to 3 minutes to avoid causing cardiac arrhythmias and more dangerously, death.
4. Side effects
During the use of Paparin, patients may experience some side effects as follows:
Effects on the central nervous system: Headache, dizziness, dizziness Effects on the digestive system: Digestive disorders , constipation, diarrhea, vomiting. Sometimes the drug can cause liver dysfunction, hepatitis. During the use of Paparin, patients need to monitor their own health. If you experience any side effects, you should immediately go to the medical center for examination and appropriate treatment.
5. Paparin drug interactions
During use, Paparin can interact with some other drugs leading to some of the following problems:
Paparin can reduce the effect of Levodopa by blocking the Dopamine receptors. Since then, co-administration with Levodopa will significantly reduce the therapeutic effect for Parkinson's disease. Although Paparin is less likely to cause central nervous system depression, it has a synergistic effect with Morphine. Therefore, when these two drugs are used concurrently, there will be an increase in central nervous system depression. Paparin is metabolized by liver enzymes, so it is absolutely forbidden to use with drugs that inhibit liver enzymes such as macrolide antibiotics, azole antifungals such as itraconazole, clarithromycin,... because this will cause interact with and affect the treatment process.
6. Overdose and Overdose Management
The overdose of Paparin can cause serious health effects, even increase the risk of death. Some common signs of overdose include nausea, vomiting, dizziness, sweating, and muscle weakness. Occasionally, vasomotor disturbances, arrhythmias, apnea, and cardiac arrest occur.
When the body shows the above signs, the patient should immediately go to the nearest medical facility for timely treatment.
Normally, the patient will be protected by airway, can give artificial respiration in case of need. If there are symptoms of convulsions, the patient will be given sedatives, anesthesia....
7. Notes when using Paparin
In order for the use of Paparin to promote the best effect, avoid causing side effects, patients need to pay attention to the following issues:
People with glaucoma, hepatitis, liver dysfunction need treatment Adjust the dose to ensure it is suitable for your health condition. When the drug is administered intravenously, the patient should be carefully monitored. Paparin should not be used for a long time because it can lead to dependence on the drug. Above is some information about Paparin drug that readers can refer to. Because this is a drug used through injection or infusion, the patient needs to be supported by medical professionals to ensure safety for health.
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