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Uses of Progendo

Progendo 200mg with the main ingredient progesterone, is a drug used to prevent endometrial hyperplasia in postmenopausal women who are not having surgery and are taking estrogen therapy. How should Progendo be used to get the best results?

1. What is Progendo?

With the main ingredient is Progesterone, Progendo drug has the following effects: treating disorders caused by Progesterone deficiency. Progesterone is a hormone produced by the corpus luteum and placenta. Progesterone helps prevent endometrial hyperplasia. With the natural properties of the hormone Progesterone, Progendo 200mg has the effect of supplementing hormones, promoting pregnancy, anti-estrogen, mild anti-androgen, anti-aldosterone, preventing miscarriage due to luteal insufficiency, providing more luteal in the luteal phase. pregnancy period.
After oral administration, Progendo is absorbed from the gastrointestinal tract and rapidly metabolized in the small intestine and liver.
After vaginal application, Progendo is rapidly absorbed through the vaginal mucosa. Elimination is mainly in the urine, 95% in the form of glucuronide conjugates as 3α, 5β-pregnanediol.

2. Indications of the drug Progendo


Oral:
Prevention of endometrial hyperplasia in postmenopausal women who have not had a hysterectomy and are taking estrogen therapy. Treatment of secondary amenorrhea. Combination in the treatment of uterine bleeding due to dysfunction. Vaginal:
luteal phase support in in vitro fertilization (IVF). Luteal phase support in spontaneous cycles or induced in reduced fertility, primary or secondary infertility due to variability in ovulation. Threatened miscarriage and prevention of recurrent miscarriages due to luteal insufficiency.

3. Contraindications to the drug Progendo


Oral:
Hypersensitivity to progesterone or to the components of the drug. The capsules contain peanut (peanut) oil, so people who are allergic to peanuts (peanuts) should not take the medicine. Used as a pregnancy test. Thrombophlebitis, thromboembolism, ventriculomegaly or patients with a history of these conditions. Poor liver function or severe liver disease. Cancer of the breast or reproductive organs has been diagnosed or suspected. Undiagnosed vaginal bleeding. Vaginal route:
Hypersensitivity to progesterone or to the components of the drug. Undiagnosed vaginal bleeding. Precautions for use
Not indicated for use in children. Elderly: Undesirable effects and problems have been reported to be similar in the elderly and in the young. A general examination is required before starting treatment. A history of certain endocrine diseases may alter the effectiveness of Progendo . This Progendo should be taken away from meals. Inform physician in case of unusual, persistent or recurrent vaginal bleeding, to rule out possible malignancy. Be careful when driving or operating machinery, because the drug can cause drowsiness, dizziness. During pregnancy, only use Progendo vaginally, not orally. Lactation Progendo is distributed in breast milk in varying amounts, depending on the dose, so the drug should not be used while breastfeeding.

4. Dosage and how to use Progendo


How to use
Drugs for oral and vaginal administration.
Dosage
Dosage is established according to each patient's plasma hormone levels.
Oral: Prevention of estrogen-induced endometrial hyperplasia in postmenopausal women: 200 mg once daily at bedtime during the last 12 days of estrogen therapy every month.
A dose of 300mg of progesterone divided into 2 oral doses (using Progendo 200mg and Progendo 100mg ), Progendo 100mg in the morning after eating two hours and Progendo 200mg before going to bed.
Progendo dosage must be adjusted until the required uterine response is achieved. In many regimens, the last 5 to 7 days of each month are usually hormone-free, which is the period when bleeding is usually seen.
Another possible treatment with a low dose is to take Progendo 100mg once daily (taken at bedtime) with the same period of estrogen therapy.
Treatment of secondary amenorrhea: 400mg x 1 time/day x 10 days, taking pills in the evening. Combination in the treatment of uterine bleeding due to dysfunction: From 200 to 300mg (using Progendo 200mg and Progendo 100mg if needed) 1 day divided into 2 oral doses. Vaginal: Support for the luteal phase in in vitro fertilization (IVF): The recommended dose is 400-600mg of Progendo per day, from day 1 when GCH is injected until week 12 of pregnancy.
Support the luteal phase in cycles spontaneously or induced in reduced fertility, primary or secondary infertility due to variation in ovulation: The recommended dose is 200mg Progendo/day, from day 17 of the cycle, within 10 days and reinstitute as soon as possible in case amenorrhea and pregnancy are diagnosed.
Threat of miscarriage and prevention of recurrent miscarriage due to luteal insufficiency: The recommended dose is 200-400mg Progendo/day, divided into 2 times.

5. Side effects of Progendo


Common side effects when using Progendo can include:
Abdominal pain; Facial edema; Swollen joints or legs; Slight increase in blood pressure, mild headache; Mood swings, anxiety, drowsiness. Above is important information about the drug Progendo. Using the right medication for the right purpose and dose will help the process of using the drug and treating it more effectively.

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