Professor, Ph.D, MD Fernando J F Martinez

Professor Fernando J F Martinez received his medical degree from the  FAMERP in Sao Jose do Rio Preto in 1986. He completed his Internal Medicine Residency at the University of Sao Paulo in 1989. He continued his medical training at A.C Camargo Cancer Center in Sao Paulo and finished his Hematology and Oncology fellowship in 1992. Dr. Martinez is Board Certified in Internal Medicine, Hematology and Oncology.
He belongs to the American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR), European Society of Medical Oncology (ESMO), Brazilian Society of Clinical Oncology (SBOC), Brazilian Society of Bone Marrow Transplantation (SBTMO) and Brazilian Society of Cancerology (SBC), and is an active member from SIOP (Société Internationale d’Oncologie Pediatric).
He defended his Master’s Degree in 1996, in a Cotutelle program organized between Ludwig Institute for Cancer Research and the Ezra M. Greenspan Chair in Clinical Cancer Therapeutics at the Cancer Chemotherapy Foundation at the Mount Sinai Hospital in New York. He subsequently defended his Ph.D. Thesis in Biological Sciences with: “Mathematical Modeling in Cancer. Predictive factors in Cancer Response to Chemotherapy”, the Institute of Biological Sciences and Ludwig Institute for Cancer Research and the second Ph.D. Thesis defense in Experimental Oncology “Phase II Study – Efficacy and toxicity evaluation of UFT and Tegafur associated to LV, comparing two different administration schedules as treatment of metastatic colon cancer”.
Dr. Martinez has spent more than 35 years treating a wide range of oncologic and hematologic disorders in University Teaching Hospitals and Private Practice in Brazil and internationally. His domains of expertise include Breast cancer, Bone and Soft Tissue Sarcomas, Prostate Cancer, Gastric Cancer, Colon and Rectal Cancers, non-Hodgkin Lymphomas, Head and Neck Cancers, and Lung Cancer.
He worked in major medical institutions such as Gustave Roussy Institute, European Hospital Georges Pompidou, and Brugmann University Hospital.
Throughout this trajectory, he has focused on Personalized Medicine, seeking to reflect, know, and prioritize the importance of patients’ well-being and quality of life – with strict adherence to protocol guidelines and adapting the situation when necessary.
"Treatment of cancer patients must be based on the person, a personalized and evidence-centered context. Therapeutic strategies must respect and be defined in the knowledge of the patient, as an individual being able to meet the most authentic wishes of each one, valuing what is important for the patient according to their sociocultural values," Doctor Martinez defines his clinical practice.
He is now the Medical Director of the Oncology Center at Vinmec Central Park International Hospital.

1. MATHIAS, C ; SENA, e P ; DEMORAES, C. ; BRAGHIROLI, M ; ROCHA, I ; NUNEZ, G ; ATHANAZIO, R ; LESSA, G S ; MARTINEZ, F. J. . Bupropion improves sexual function in women diagnosed with breast cancer. A pilot study in this population. In: 42nd Annual Meeting of the American Society of Clinical Oncology, 2006, Atlanta, GA. Journal Clinical Oncology, 2006. v. 24. p. 318s.
2. MARTINEZ, F. J.; RAMOS, e ; BENSI, C G ; CENTOFANTI, G ; FRANKFURT, S ; GARCIA, A P ; TANNOUS, N G . Spirituality correlates positively with higher quality of life and negatively with depression in a sample of low-income Brazilian cancer patients. In: 42nd Annual Meeting of the American Society of Clinical Oncology, 2006, Atlanta, GA. Journal Clinical Oncology, 2006. v. 24. p. 690s.
3. MATHIAS, C ; MORAES, F. ; BASTOS, C ; ATHANAZIO, R ; NUNEZ, G ; ALBAN, L. ; BRAGHIROLI, M ; MARTINEZ, F. J. . Bupropion in the treatment of sexual dysfunction in women diagnosed with breast cancer: an open-label, fixed dose study. In: 42nd Annual Meeting of the American Society of Clinical Oncology, 2006, Atlanta, GA. Journal of Clinical Oncology, 2006. v. 24. p. 318s-318s.
4. TOBIAS-MACHADO, M ; FONSECA, F ; FANTINATO, A P ; WROCLAWSKI, M L ; WROCLASKI, e R ; MARTINEZ, F. J. . CK-19 expression by RT-PCR in the peripheral blood of prostate cancer patients. In: 41st Annual Meeting of the American Society of Clinical Oncology, 2005, Orlando, FL. Journal Clinical Oncology, 2005. v. 23. p. 411s.
5. MARTINEZ, F. J.; DANTAS, A A P H ; BURGOS, A R M . A phase II study of the combination of topotecan, Ara-C, cisplatin and prednisolone (TOPOSHAP) for salvage of primary refractory and relapsed patients with lymphoid malignancies. In: 47th Annual Meeting of the American Society of Hematology, 2005, Atlanta, GA. Blood, 2005. v. 106. p. 263b.
6. YAMAGUCHI, N H ; MAYER, I A ; MALZYNER, A ; ANDRADE, C J C ; MURAD, A M ; MARTINEZ, F. J. ; CARDOSO, H. A pilot feasibility study of gefitinib (ZD1839) and celecoxib in metastatic GI tumors. In: 40th Annual Meeting of the American Society of Clinical Oncology, 2004, New Orleans, LA. Proceedings of the 40th Annual Meeting of the American Society of Clinical Oncology, 2004. v. 23. p. 216.
7. BARROS, C H ; VIOLA, F ; CAMILLOCOURA, L ; SILVA, R F ; MARTINEZ, F. J. ; MATHIAS, C. Phase II study of capecitabine and irinotecan as first-line treatment in metastatic colorectal cancer: first trial of the Brazilian Oncology Consortium (BOC-CRC 001). In: 40th Annual Meeting of the American Society of Clinical Oncology, 2004, New Orleans, LA. Proceedings of the 40th Annual Meeting of the American Society of Clinical Oncology, 2004. v. 23. p. 301-301.
8. MARTINEZ, F. J.; FONSECA, F L A ; SANTANA, A ; PINHAL, M A S ; BENDIT, I ; MEGALE, L ; ARIAS, V . Microsatellite instability (MSI) and loss of heterozigocity (LOH) in the peripheral blood mononuclear cells (PBMC) of breast cancer (BC) patients receiving systemic chemotherapy. In: 40th Annual Meeting of the American Society of Clinical Oncology, 2004, New Orleans, LA. Proceedings of the 40th Annual Meeting of the American Society of Clinical Oncology, 2004. v. 23. p. 862.
9. IBANA-SAMANO, E. ; MARTINEZ, F. J. ; RIBEIRO, L M ; CAMPOS, A S ; LEWIN, F ; VALESIN FILHO, D S ; GOLDENSTEIN, P T ; COSTA, L J M . Use of complementary/alternative medicine by Brazilian oncologists. In: 40th Annual Meeting of the American Society of Clinical Oncology, 2004, New Orleans, LA. Proceedings of the 40th Annual Meeting of the American Society of Clinical Oncology, 2004. v. 23. p. 301.
10. SOARES, H P ; SANTUCCI, R ; KUMAR, A ; DJULBEGOVIC, B ; GLASGERG, J ; MARTINEZ, F. J. . Detection of cytokeratin-19 in peripheral blood of breast cancer patients: result from a systematic review/meta-analysis. In: 46th Annual Meeting of the American Society of Hematology, 2004, San Diego, CA. Blood, 2004. v. 104. p. 413b.
11. COUTINHO, F ; MARTINEZ, F. J. ; MANHANI, A R . Phase I/II study of the combination of topotecan, Ara-C, cisplatin and high dose solumedrol (TOPOSHAP) in patients with relapsed lymphoma. In: 39th Annual Meeting of the American Society of Clinical Oncology, 2003, Chicago, IL. Proceedings of the 39th Annual Meeting of the American Society of Clinical Oncology, 2003. v. 22. p. 617.
12. ZATTA, S ; MARTINEZ, F. J. . Intravenous 5-FU versus oral UFT (tegafur and uracil) both modulated by leucovorin: a randomized uni-institutional cross-over trial with quality of life evaluation in metastatic colorectal cancer. In: 39th Annual Meeting of the American Society of Clinical Oncology, 2003, Chicago - IL. Proceeding of the 39th Annual Meeting of the American Society of Clinical Oncology, 2003. v. 22. p. 766.
13. BOLLMANN, P ; MARTINEZ, F. J. . Immunocytochemical detection of micrometastasis in the bone marrow of breast cancer patients: a meta-analysis. In: 45th Annual Meeting of the American Society of Hematology, 2003, San Diego, CA. Blood, 2003. v. 102. p. 749a.
14. SOARES, H P ; MARTINEZ, F. J. ; SILVA, R S ; CLARK, O ; KUMAR, A ; DJULBEGOVIC, B . Reverse transcriptase polymerase chain reaction for minimal residual disease detection in the peripheral blood of women with breast cancer: a meta-analysis. In: 39th Annual Meeting of the American Society of Clinical Oncology, 2003, Chicago, IL. Proceedings of the 39th Annual Meeting of the American Society of Clinical Oncology, 2003. v. 22. p. 878.
15. GUSMAO, C R A B ; BINES, J ; MARTINS, R G ; CARMO, P A O ; MARTINEZ, F. J. ; CABRAL, C ; VINHOLES, J . Primary chemotherapy with weekly docetaxel (taxotere) in poor prognosis locally advanced breast cancer (LABC). In: 38th Annual Meeting of the American Society of Clinical Oncology, 2002, Orlando, FL. Proceedings of the 38th Annual Meeting of the American Society of Clinical Oncology, 2002. v. 21. p. 42b.
16. FONSECA, F L A ; SOARES, H P ; MANHANI, A R ; BENDIT, I ; NOVAES, M ; ZATTA, S M ; ARIAS, V ; PINHAL, M A S ; WEINSCHENKER, P ; MARTINEZ, F. J. . Detection of c-erbB-2 expression in the mononuclear fraction of the peripheral blood by reverse transcriptase-polymerase chain reaction in patients with breast cancer receiving chemotherapy. In: 38th Annual Meeting of the American Society of Clinical Oncology, 2002, Orlando, FL. Proceedings of the 38th Annual Meeting of the American Society of Clinical Oncology, 2002. v. 21. p. 304b.
17. BINES, J ; VINHOLES, J ; MARTINEZ, F. J. ; CABRAL, C ; VASCONCELOS A ; GUSMAO C ; MARTINS, R G ; CARMO, P A O . Induction chemotherapy with weekly docetaxel (taxotere) in unfavorable locally advanced cancer (LABC). In: 25th Annual San Antonio Breast Cancer Symposium, 2002, San Antonio, TX. Breast Cancer Research Treatment, 2002. v. 76. p. S54.
18. MANHANI, A R ; MANHANI, R ; BENDIT, I ; FONSECA, F L ; NICOLETTI, A G B ; ZATTA, S M ; MARTINEZ, F. J. . Serial RT-PCR for detection of CK-19 expression in the peripheral blood mononuclear (PMN) fraction of breast patients before and after chemotherapy. In: 36th Annual Meeting of the American Society of Clinical Oncology, 2000, New Orleans, LA. American Society of Clinical Oncology, 2000. v. 19. p. 128a.
19. SOARES, H P ; MARTINEZ, F. J. ; CAPARROZ, C. Granisetron is equivalent to ondansetron for prophylaxis of chemotherapy induced nausea and vomiting: results of a meta-analysis of randomized controlled trials. In: 36th Annual Meeting of the American Society of Clinical Oncology, 2000, New Orleans, LA. Proceedings of the 36th Annual Meeting of the American Society of Clinical Oncology, 2000. v. 19. p. 626a.
20. UEHARA, R P ; MOTA, A ; REZENDE, L F ; ZATTA, S M ; CASA, e S ; NEVOLA, A C ; CORDEIRO, J L ; MARTINEZ, F. J. . Teaching clinical oncology to medical students through a specially designed student staffed weeky continuity clinic. In: 34th Annual Meeting of the American Society of Clinical Oncology, 1998, Los Angeles, CA. Proceedings of the 34th Annual Meeting of the ASCO, 1998. v. 17. p. 427.
21. NOVAES, M ; BENDIT, I ; GARICOCHEA, B ; MARTINEZ, F. J. . Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of cytokeratin 19 (CK-19) expression in the peripheral blood mononuclear cells (PBMN) of normal female blood donors. In: 33rd Annual Meeting of the American Society of Clinical Oncology, 1997, Denver, CO. Proceedings of the 33rd Annual Meeting of the American Society of Clinical Oncology, 1997. v. 16. p. 111a.
22. MARTINEZ, F. J.; BENDIT, I ; ODONE FILHO, V ; CRISTOFANI, L M ; MANHANI, R ; NOVAES, M ; CHAMONE, D A F ; BLYDOWSKI, S P . MDR-1 expression correlates with N-MYC amplification in pediatric neuroblastoma. In: 31st Annual Meeting of the American Society of Clinical Oncology, 1995, Los Angeles, CA. Proceeding of the 31st Annual Meeting of the American Society of Clinical Oncology, 1995. v. 14. p. 432.
23. GARICOCHEA, B ; CLIQUET, M G ; MELO, N B ; BEITLER, B ; MARTINEZ, F. J. . Determination of lymphocyte clonality in the cerebrospinal fluid (CSF) of a patient with chronic lymphoid leukemia (CLL) by PCR for rearranged immunoglobulin genes. In: 37th Annual Meeting of the American Society of Hematology, 1995, Seattle, WA. Blood, 1995. v. 86. p. 833a.
24. MARTINEZ, F. J.; DRASCH, J ; NOVAES, M ; LLACER, P Dorlhiac ; KHETAN, R ; ANDREEFF, M ; CHAMONE, D F ; DEISSEROTH, A B . PCNA expression in peripheral blasts of patients with AML. In: 30th Annual Meeting of the American Society of Clinical Oncology, 1994, Dallas, TX. Proceedings of the 30th Annual Meeting of the American Society of Clinical Oncology, 1994. v. 35. p. 2133.
25. DRACH, J ; MARTINEZ, F. J. ; KHETAN, R; JOHNSTON, D ; HESTER, J ; DEISSEROTH, A B ; ARCHEEP, M . Analysis of proliferating cell nuclear antigen (PCNA), Ki-67 and DNA/RNA in acute myelogenous leukemia (AML) treated with G-CSF and IL-3 in vivoh G-CSF and IL-3 in vivo. In: XVI Congress of the International Society for Analythical Cytology, 1993, Colorado Springs, CA. Proceedings of the XVI Congress of the International Society for Analytical Cytology, 1993. v. 34. p. 163.
26. KORNBLAU, S ; CHEN, N ; MARTINEZ, F. J. ; OBRIEN, S ; DEISSEROTH, A B . Retinoblastoma protein expression is altered by two mechanisms in chronic lymphocytic leukemia. In: 29th Annual Meeting of the American Society of Clinical Oncology, 1993, Orlando, FL. Proceedings of the 29th Annual Meeting of the American Society of Clinical Oncology, 1993. v. 34. p. 163.
27. MARTINEZ, F. J.; NOVAES, M ; LLACER, P Dorlhiac ; DEISSEROTH, A B ; DRASCH, J ; KHETAN, R ; CHAMONE, D A F . Expressão do antígeno de proliferação celular (PCNA) em blastos do sangue periférico de pacientes com LMA. In: XIV Congresso Nacional do Colégio Brasileiro de Hematologia, 1993, Curitiba (PR). Resumos, 1993.
28. ZHANG, W ; MARTINEZ, F. J. ; KANTARJIAN, H ; TALPAZ, M ; DEISSEROTH, A B . Nuclear P53 protein increases from normal levels in chronic phase CML to high levels in peripheral blood cells of most blast crisis CML patients. In: 27th Annual Meeting of the American Society of Clinical Oncology, 1991, Houston, TX. Proceedings of the 27th Annual Meeting of the ASCO, 1991. v. 10. p. 39.
29. KORNBLAU, S ; MARTINEZ, F. J. ; ZHANG, W ; ZU, H ; BENEDICT, W F ; DEISSEROTH, A B . Patterns of expression of the retinoblastoma anticogene in leukemia. In: 82nd Annual Meeting of the American Association for Cancer Research, 1991, Houston, TX. Proceedings of the 82nd Annual Meeting of the American Association for Cancer Research, 1991. v. 32. p. 309.
30. MARTINEZ, F. J.; ZHANG, W ; OBRIEN, S ; KEATING, M ; KORNBLAU, S ; JOHNSTON, D ; MANNING, J T ; DEISSEROTH, A B . Relationship of elevated intranuclear P53 levels in chronic lymphocytic leukemia to marrow architecture and PCNA antigen expression. In: 82nd Annual Meeting of the American Association for Cancer Research, 1991, Houston, TX. Proceedings of the 82nd Annual Meeting of the American Association for Cancer Research, 1991. v. 32. p. 290.
31. MARTINEZ, F. J.; KHETAN, R ; OBRIEN, S ; KEATING, M ; DEISSEROTH, A B . Proliferating cell nuclear antigen levels are high in advanced stage chronic lymphocytic leukemia and correlate with the clinical doubling time of this disease. In: 33rd Annual Meeting of the American Society of Clinical Oncology, 1991, Denver, CO. Blood, 1991. v. 78. p. 311a.
32. MARTINEZ, F. J.; MAVLIGIT, A. . Severe symptomatic dose-limiting hypophosphatemia induced by hepatic arterial infusion of recombinant TNF in patients with liver metastases. In: 81st Annual Meeting ofthe American Association for Cancer Research, 1990, Washington, DC. Proceedings of the 81st Annual Meeting of the American Association for Cancer Research, 1990. v. 31. p. 175.
33. MARTINEZ, F. J.; SAVARAJ, N ; CASTELLO, C ; TAPIERO, H ; WHITE, L ; LAMPIDIS, T J . Comparative effects of menogaril and adriamycin on cardiac antimultidrugs resistant tumor cells. In: 80th Annual Meeting of the American Association for Cancer Research, 1989, San Francisco, CA. Proceedings, 1989. v. 30. p. 613-613.

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