Ph.D Nguyen Xuan Hung

Ph.D Nguyen Xuan Hung graduated with a Ph.D. degree in Molecular Immunology from the Borstel Research Center in Borstel, Germany. He was a Postdoctoral Research Fellow at Institute of Molecular and Cellular Biology (IBMC) in Strasbourg and Center for Pathophysiology of Toulouse Purpan (CPTP), France. He is:

• An orchestrator who is effectively conducting multiple simultaneous projects

• An  inventor who developed a novel immobilized method to select scFv antibodies from phage display library
• A DNA hacker who can cut, copy and paste DNA sequences as text editing
• A producer who generated lentiviral packaging mix and some linearized vectors having similar efficacy as the related commercial ones
• An  engineered who manipulated the genome of yeast, Drosophila, and mouse

After several years carrying out studies focus on mechanistic analysis of novel regulators in Fas-induced apoptotic and NF-kB signaling pathways, he is currently characterizing the immunopathogenesis of an autoimmune disease and setting up a human induced pluripotent stem cell (hiPSC) core facility for disease modeling and drug development.

In addition, he is coordinator, and principal translator of the Harvey Lodish’s Molecular cell biology textbook into Vietnamese, an editor of a Vietnam Biotechnology website, and a co-founder and former president of The Vietnamese Students' Association in Strasbourg

• Nguyen X-H*#, Dauvilliers Y, Quériault C, Perals C, Romieu-Mourez R, Paulet PE, Bernard-Valnet R, Fazilleau N, Liblau R#. 2018. Circulating follicular helper T cells exhibit reduced ICOS expression and impaired function in narcolepsy type 1 patients. J. Autoimmun. 94:134-142. (IF:7.6)

• Nguyen X-H*#, Trinh TL, Vu TBH, Le QH & To KA. 2018. Isolation of phage display library-derived scFv antibody specific to Listeria monocytogenes by a novel immobilized method. J Appl Microbiol. 124(2): 591-597. (IF:2.1)

• Trung KH*, Nguyen TK, Khuat HBT, Nguyen TD, Khanh TD, Xuan TD & Nguyen X-H#. 2017. Whole genome sequencing reveals the islands of novel polymorphisms in two native aromatic japonica rice landraces from Vietnam. Genome Biol Evol. 9(6): 1816-1820. (IF:3.9)                                                                                                                      

• Hartmann FJ*, Bernard-Valnet R, Quériault C, Mrdjen D, Weber L, Galli E, Krieg C, Robinson MD, Nguyen X-H, Dauvilliers Y, Liblau R# & Becher B#. 2016. High-dimensional single-cell analysis reveals the immune signature of narcolepsy. J Exp Med. 213(12):2621-2633. (IF:10.7)

• Stienne C*, Michieletto MF*, Benamar M, Bernard I, Carrié N, Nguyen X-H, Lippy Y, Liblau RS, Hedrick SM, Saoudi A & Dejean AS#. 2016. Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes. Immunity. 45(4):774-787. (IF:19.7)

• Nguyen X-H*, Saoudi A & Liblau RS#. 2016. Vaccine-associated inflammatory diseases of the central nervous system: from signals to causation. Curr Opin Neurol. 29(3):362-371. (IF:4.0)

• Bernard-Valnet R*, Yshii L, Quériault C, Nguyen X-H, Arthaud S, Rodrigues M, Canivet A, Morel AL, Matthys A, Bauer J, Pignolet B, Dauvilliers Y, Peyron C & Liblau R#. 2016. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Proc Natl Acad Sci U S A. 113(39):10956-61. (IF:9.5)        Highlighted in Nat. Rev. Neurosci. 2016. 17(11):374-374

• Bonnay F*, Nguyen X-H*, Cohen-Berros E, Troxler L, Batsche E, Camonis J, Takeuchi O, Reichhart JM & Matt N#. 2014. Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. EMBO J. 33(20):2349-2362. (IF:10.5)                           

• Nguyen X-H*, Fattakhova G, Lang P, Lang K, Adam D, Foeger N & Lee KH#. 2012. Antiapoptotic function of Toso (Faim3) in death receptor signaling. Blood. 119(7):1790-1791. (IF:15.1)                             

• Nguyen X-H*, Lang P*, Lang K*, Adam D*, Fattakhova G*, Foeger N, Kamal A, Prilla P, Mathieu S, Wagner C, Mak TW, Chan AC & Lee KH#. 2011. Toso regulates the balance between apoptotic and non-apoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 118(3):598-608. (IF: 15.1)

• Nguyen X-H*, Nghiem NM & Dang TCH#. 2004. Biodegradation of oil by the strain BSHL5 bacteria isolated from Cua Luc in Quang Ninh. Vietnam J Biotechnol. 2(2):253-264.