Evaluation of highly sensitive C-reactive protein (hsCRP) in the risk of inflammation and heart disease

The article was professionally consulted by Specialist Doctor II Ho Viet Le Diem - General Internal Medicine - Department of Examination & Internal Medicine - Vinmec Central Park International General Hospital.

To investigate the increasing prevalence of cardiovascular disease risk, the highly sensitive C-reactive protein assay is a valuable laboratory test to assess the risk of inflammation in cardiovascular diseases. , from which the most appropriate treatment method will be determined.

Cardiovascular disease is considered one of the diseases causing high mortality in most developed countries and is in a period of rapid increase in developing countries. This is a disease of the circulatory system in the human body, so it greatly affects other organs as well as the patient's life.
Therefore, if detected in time, control of the disease as well as a good prognosis is possible. Several studies have demonstrated that there are many cases of patients with cardiovascular disease without any risk factors for cardiovascular disease. On the other hand, cardiovascular diseases have been found to be related to inflammation, in particular, when inflammation causes changes in the coronary epithelium, which leads to atherosclerosis.
Therefore, to investigate the risk of heart disease, the assessment of the risk of inflammation is extremely important and has high value in the diagnosis of this disease, and one of the most specific tests today is the hs test. - CRP.

High-sensitivity C-Reactive Protein Evaluation also known as hs-CRP test is a type of laboratory test performed to quantify C-reactive protein or CRP present in serum as well as plasma of patient.
The hs - CRP test has the ability to find out inflammatory disorders taking place in the patient's body, thereby detecting related diseases, including cardiovascular disease.
C-reactive protein or CRP is a classical acute-phase protein involved in inflammatory responses. This type of protein is produced in the liver, there are 5 polypeptide chains of the same structure completely joined together into a 5-part ring. CRP, along with a number of other heart disease risk tests, has the ability to assess inflammation as well as coronary heart disease risk.
More specifically, the hs - CRP test is now very commonly used as a marker to predict the risk of coronary heart disease in healthy patients and can also predict recurrence of the disease after previous treatment.
The reason hs - CRP test plays an extremely important role in the assessment of inflammation risk is:

The hs - CRP test works on the principle that human CRP is able to agglutinate with latex particles coated with monoclonal antibodies with anti-CRP properties CRP is almost stable for 24 hours Long CRP half-life CRP can be assessed through fresh patient plasma or frozen plasma High sensitivity of CRP in the assessment of inflammatory risk Cost of hs - CRP testing may be acceptable Some considerations when evaluating Protein High sensitivity C-reactive is that there are a number of factors that can affect the test results, misrepresent the inflammatory state of the body, so it is necessary to pay attention to patients with the following factors:
Patients using some non-steroidal anti-inflammatory drugs, Aspirin, Corticosteroids, Statins, Beta-blockers will lead to false negative hs - CRP test. Patients using hormone replacement drugs, oral contraceptives drinking will cause the test result to be false positive Patient has contraceptive devices placed in the uterus Young patient Experiencing exercise or extreme physical activity Pregnant patients Patients with obesity In cardiovascular disease and high-sensitivity C-reactive protein assessment for this pathology, the indication is usually given with Male patients 50 years of age or older and female patients under 60 years of age were at intermediate risk.
In addition, the hs - CRP test is also of high value in treating patients who are older than 50 years of age for men, more than 60 for women if these patients have an LDL-C index lower than 3.33 mml or 130 mg/L and no other heart disease, diabetes, kidney disease, or other inflammatory disease. For patients with mild inflammation that persists for a long time, hs-CRP testing should be ordered to check for this condition, hs-CRP testing should be done more than once in these cases. In this case, there is usually a 2 week interval between the two tests, and the patient may have to fast for the test results to be accurate.

The hs - CRP test has great clinical significance in patients with inflammatory conditions, especially cardiovascular diseases. More specifically, when this test index increases, the patient is at risk of cardiovascular conditions, along with tests for cholesterol and triglyceride levels. coronary heart disease, heart attack, stroke...
hs - CRP test not only assesses the risk of inflammation but also has the ability to predict as well as survey the risk of heart disease, helping patients to predict their risk of disease. Therefore, when there is any abnormality, the patient needs to go to a reputable medical facility for examination and necessary tests.
Vinmec International General Hospital is one of the hospitals that not only ensures professional quality with a team of leading medical doctors, modern equipment and technology, but also stands out for its examination and consultation services. comprehensive and professional medical consultation and treatment; civilized, polite, safe and sterile medical examination and treatment space. Customers when choosing to perform tests here can be completely assured of the accuracy of test results.
Doctor Ho Viet Le Diem has more than 10 years working in the Department of Resuscitation - Cardiac Surgery at Cho Ruong Hospital with the position of cardiologist and Open Heart Resuscitation. And has more than 03 years as a General Internal Medicine doctor at Family Medical Practice in Ho Chi Minh City. Currently, Dr. Diem is working at the Internal Medicine Department - Vinmec Central Park International General Hospital.