Learn about the ctDNA liquid biopsy method for cancer diagnosis

Liquid biopsy ctDNA to help find cancer cells is one of the breakthrough methods, bringing many unexpected and very desirable results in the future.

1. What is ctDNA liquid biopsy?

Along with the development of modern medicine today, finding and treating cancer is no longer a difficult problem.
As cancers grow, they remove excess cells, cell fragments and DNA from programmed cell death or cancer cells that die from external causes. These cells enter the bloodstream and circulate throughout the body. The fragments of cancer DNA that circulate in the blood are called ctDNA.
ctDNA liquid biopsy is the non-invasive taking of a blood sample to look for cells with certain characteristics, such as circulating tumor cells and circulating tumor nucleic acids in the blood , which are fragments of DNA or RNA. Because of its non-invasive nature, this biopsy method does not present the surgical risks associated with tissue biopsies.

2. Procedure for performing liquid biopsies

For many research centers and large hospitals today, the ctDNA liquid biopsy test procedure is performed as follows:
Take 2 blood tubes to perform liquid biopsy test; Analysis by digital sequencing technology; Find active gene mutations on 73 genes; The doctor receives the results after 2-3 weeks; Results management and post-test counseling.

Lấy máu — Mẫu máu được lấy làm sinh thiết lỏng ctDNA

3. Prospect of liquid biopsy ctDNA test in cancer diagnosis

Because liquid biopsies evaluate ctDNAs from the entire tumor (or tumors) rather than a single tissue sample, they can provide more comprehensive information about composition as well as identification. complexity of mutations. Single cell analyzes will help identify cancer cell populations and can find common features for cancer-causing mutations, as well as collect mutations that are specific to most lines. cancer to realize highly effective and specific immunotherapies.
The ctDNA liquid biopsy method allows us to detect up to 9 types of cancer: Lung cancer, ovarian cancer, colorectal cancer, breast cancer, melanoma, bladder cancer, esophageal cancer, myeloid cancer, and soft tissue sarcoma.

Liquid biopsies will develop even more in the coming future. In the near future, Medicine will move from single sample analysis - a method that can only provide a narrow and immediate picture for the assessment of a whole cancer progression to research studies. comprehensive, long-term monitoring of cancer progression throughout the treatment period.
The technology of ctDNA liquid biopsy for cancer diagnosis, combined with targeted therapies, immunotherapy and other advanced treatments, will bring great benefits in the treatment of cancer patients. cancer patient.
For detailed advice on this method, please go directly to Vinmec Health system or book online HERE.

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Bài viết này được viết cho người đọc tại Sài Gòn, Hà Nội, Hồ Chí Minh, Phú Quốc, Nha Trang, Hạ Long, Hải Phòng, Đà Nẵng.