The role of erythrocyte endurance in blood diseases

The article was written by Pediatrician, Pediatric Center - Vinmec Times City International Hospital.

The red blood cell membrane is a semi-permeable membrane, so if the red blood cells are placed in a hypotonic saline solution, water from the outside will enter the red blood cells to enlarge the red blood cells. The weaker the solution, the more water (the lighter) the water enters the red blood cells, the more fragile the red blood cells are. Take advantage of this property to evaluate the stability of erythrocytes at different concentrations of hypotonic saline.

+ Increased erythrocyte endurance: when red blood cells in a saline solution are low, but red blood cells are broken less than normal red blood cells in a saline solution of the same concentration.
+ Decreased erythrocyte endurance: when red blood cells in saline solution are higher, but red blood cells are broken more than normal RBCs in saline solution of the same concentration.

Decreased erythrocyte endurance
Seen in hereditary microcytosis (this is autosomal dominant in 75% of cases linked to the short arm ANKIRIL gene on chromosome 8, associated with Beta-Spectrin deficiency, 25% not familial. Suspected chromosomal abnormality often associated with Alpha-Spectrin. Thalassemia is an inherited hemoglobinopathy caused by a deficiency in the synthesis of one or more polypeptide chains in hemoglobin globulin Sickle cell anemia

Normal HC endurance
Due to lack of enzyme Pyruvatkina G6PD deficiency is the first enzyme of Pentophosphate process in sugar metabolism Glucose deficiency G6PD reduces the reducing energy of red blood cells causing hemolysis And most other blood diseases Normal SBHC Disease Vinmec International General Hospital is one of the hospitals that not only ensures professional quality with a team of leading medical professionals, modern equipment and technology, but also stands out for its examination, consulting and service services. comprehensive and professional medical treatment; civilized, polite, safe and sterile medical examination and treatment space. Customers when choosing to perform tests here can be completely assured of the accuracy of test results.
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