Aprovel side effects

Aprovel is an antihypertensive drug with irbesartan as the main ingredient. Like many other drugs, aprovel can also cause some side effects when used, which should be taken into account.

The active ingredient Aprovel is Irbesartan, a class of antihypertensive drugs called Angiotensin-II receptor antagonists.
Mechanism of action of Angiotensin-II receptor antagonists: When the body realizes that there is a lack of blood supply to the kidneys, it will produce a substance called renin, which has a catalytic effect on the process. converts from Angiotensinogen to Angiotensin I (this substance has a weak vasoconstrictor effect causing hypertension). These substances then pass through the pulmonary capillaries and form Angiotensin-II, a substance that, when attached to receptors in the blood vessels, causes blood vessels to contract strongly and increase blood pressure. Antihypertensive drugs of the Angiotensin-II receptor antagonist class have the effect of competing with the binding site of this substance on the vessel wall, causing this substance to be produced but not attached to the vessel wall and cause vasoconstriction. Thereby causing the effect of vasodilating and lowering blood pressure, in addition, the drug also has another effect that is to reduce water retention and sodium retention, so it also lowers blood pressure.
Aprovel is often used to treat high blood pressure, especially in cases of hypertension with type 2 diabetes, people with kidney disease. Because it can slow down the decline in kidney function in people with high blood pressure and diabetes. In addition, the drug is also an alternative option when patients cannot take ACE inhibitors.

Aprovel, like most other medicines, can also cause unwanted effects. Some side effects that may occur when using this medicine include:
Dizziness, feeling tired. Digestive disorders such as abdominal pain, loss of appetite, vomiting and nausea, belching, indigestion. Rare effects may be observed: Increase in plasma creatinine, which may cause erythrocytosis, decreased hematocrit, reversible thrombocytopenia. Postural hypotension, palpitations. Musculoskeletal pain, skin erythema, rash. Hyperkalemia is commonly seen in people with diabetes and kidney disease. Sexual dysfunction. In addition, when taking the drug, there may be some very rare reported symptoms such as taste disturbances, hallucinations, liver dysfunction and jaundice.

In order to use the drug safely and limit the risk of side effects, patients should note the following issues:
It is necessary to inform the doctor about medical conditions, allergies, pregnancy, lactation ... Aprovel is a prescription drug, so you are not allowed to self-treat without a prescription. Follow the correct dosage and usage as prescribed by your doctor. Avoid increasing the dose on your own because it can cause dangerously low blood pressure. For pregnant and lactating women: Aprovel should be stopped before becoming pregnant or as soon as you know you are pregnant. Because Aprovel is not recommended during pregnancy because it can be dangerous to the baby if the mother takes it during the first 3 months or later of her pregnancy. Breastfeeding women: Aprovel should not be used by women who are breastfeeding because it can seriously affect the baby, especially the newborn or premature baby. At that time, your doctor will prescribe you another medicine to replace this medicine. Drugs can cause hyperkalemia, so blood tests should be done when taking medicines such as potassium supplements, potassium-containing salt substitutes, potassium-sparing diuretics, lithium-containing drugs. Pay attention when using for people with electrolyte disorders, especially hyperkalemia and hyponatremia. In addition, it should be noted when used with anti-inflammatory pain relievers. Because it can reduce the antihypertensive effect of the drug. Aprovel is a relatively safe drug with few side effects among antihypertensive drugs. However, some people may still experience side effects, most notably hyperkalemia that needs to be monitored.
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