Boruza: Uses and dosages

Boruza is a drug that treats parasites, antivirals, antifungals, and anti-infectives. Currently, the drug is being widely used in the treatment of diseases such as HIV, hepatitis B,...

Boruza medicine is a medicine with the ingredient Tenofovir disoproxil fumarate 300mg (Boruza medicine 300mg) and other active ingredients and active ingredients. This drug belongs to the group of antiparasitic, anti-bacterial, anti-fungal and anti-viral drugs.

2.1 Indications Boruza is indicated for use in the following cases:
Patients with HIV type 1 in adults, in combination with other antiretroviral drugs (do not use Boruza alone); Prevention of HIV infection after contact with HIV patients at risk of viral infection, in combination with other antiretroviral drugs; Treatment of chronic hepatitis B in adults resistant to lamivudine. 2.2 Contraindications Boruza is not used for:
Patients with hypersensitivity to Tenofovir disoproxil fumarate or other ingredients in the drug; People with severe kidney failure; Patients with abnormal neutrophils (less than 0.75 x 109/liter) or abnormal hemoglobin levels (less than 75g/liter).

Boruza can only be used with a doctor's prescription. Dosage is as follows:
Treatment of HIV infection: 1 tablet/time/day and in combination with other antiretroviral drugs; Prophylaxis of HIV infection (occupational cause): 1 tablet/time/day and in combination with other antiretrovirals and continued for the next 4 weeks if well tolerated. HIV prevention should begin as soon as possible after exposure to a high-risk HIV patient (preferably within a few hours); Prophylaxis of HIV infection (non-occupational): 1 tablet/time/day and in combination with at least 2 other antiretroviral drugs. Administration should be started as soon as possible (preferably within 72 hours of exposure to an HIV patient); Treatment of chronic hepatitis B: 1 tablet/time/day for more than 48 weeks; Patients with hepatic impairment : No dose adjustment is required; Hemodialysis patients: Take each dose 7 days apart or 12 hours after hemodialysis. The doctor needs to closely monitor the patient's condition; Patients with renal impairment: Reduce the dose of Boruza by adjusting the dosing interval based on the patient's creatinine clearance (CC). Specifically: CC ≥ 50ml/min: Usual dose 1 time/day; 30 ≤ CC ≤ 49ml/min: Take the drug every 48 hours; 10 ≤ CC ≤ 29ml/min: Take the drug every 72 - 96 hours. In case of drug overdose: Patients should be monitored for signs of toxicity and basic treatment measures can be used if necessary. The active substance Tenofovir in Boruza can be eliminated by hemodialysis.
In case of forgetting a dose while taking the medicine, the patient should take it as soon as possible (can be taken 1-2 hours apart from the time requested by the doctor). However, if it is almost time for the next dose, the patient should skip the missed dose and take the next dose at the prescribed time.

On the digestive tract: Diarrhea, nausea and vomiting, abdominal pain, indigestion, flatulence, loss of appetite,...; Skin rash; Serum amylase levels may be elevated, pancreatitis; Decrease in blood phosphate; Increased liver enzymes, hyperglycemia, increased blood triglyceride levels and neutrophil deficiency; Renal failure, Fanconi syndrome; Lactic acidosis, associated with hepatomegaly, fatty liver,...; Other side effects: Peripheral neuropathy, insomnia, headache, dizziness, depression, weakness, muscle pain, sweating,... When experiencing unwanted side effects due to drug use Boruza, the patient should notify the doctor immediately.

Proliferation of adipose tissue: After taking the drug, it can cause obesity, anterior - posterior neck hypertrophy, mammary gland enlargement, Cushing's syndrome,...; Bone side effects: Concomitant use of Boruza with lamivudine and efavirenz in HIV-infected patients may lead to a decrease in the mineral density of the lumbar spine, an increase in serum parathyroid hormone levels, and an increase in serum parathyroid hormone levels. biochemical factors in bone metabolism,...; Outbreaks of HBV (hepatitis B virus) infection in HIV-infected patients upon discontinuation of Boruza therapy. Therefore, it is necessary to monitor liver function after discontinuation of Boruza in both HIV-infected and HBV-infected patients; Patients with pre-existing liver dysfunction may experience an increase in liver function abnormalities during administration. Therefore, it is necessary to closely monitor and if the situation worsens, temporarily or completely stop taking Boruza; Stop taking the drug if aminotransferase levels increase rapidly, lactic acidosis,...; HIV patients who are severely immunocompromised at the time of initiation of Boruza therapy in combination with other drugs may develop inflammatory reactions or opportunistic infections, causing more serious or exacerbating conditions. additional disease symptoms; The drug can cause dizziness, so it should be used with caution when driving or operating machinery; Using the drug in women of reproductive age should be accompanied by effective contraceptive measures because the drug can cause adverse effects for pregnant women such as miscarriage, fetal malformations,...; Do not use the drug in women who are breastfeeding.

When using Boruza, patients need to absolutely follow the doctor's instructions to ensure the highest treatment effectiveness and reduce the risk of unwanted complications.
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