Effects of the drug Brisdelle

Brisdelle, also known by the other common name Paroxetine, belongs to a group of psychotropic drugs, specialized in the treatment of depression. Besides the effective uses that the drug brings, Brisdelle also causes many unwanted side effects.

Brisdelle is on the World Health Organization's list of essential drugs, is an antidepressant that belongs to the group of selective serotonin reuptake inhibitors.
The drug is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder, generalized anxiety disorder, and psychosis premenstrual. It is also used in the treatment of premature ejaculation in men and hot flashes associated with menopause.
Mechanism of action: The drug works by blocking the reuptake of the chemical serotonin by nerve cells in the brain.
Contraindications:
Brisdelle should not be used by patients who are allergic to any of its ingredients. The patient is and has been treated with an MAO inhibitor, thioridazine within 14 days of the drug. The patient is being treated with methylene blue injection. Paroxetine should not be used in people younger than 8 years old.

How to use:
In order for the drug to maximize its effect, the patient should take the drug in the morning, can take it during or after eating. When the patient wants to stop using the drug, the dose should be gradually reduced, should not be stopped suddenly and should consult the doctor.
Dosage:
In the treatment of depression: For adults take 1 tablet 1 time in 1 day, the maximum dose is 2 tablets 1 time / day. In the treatment of panic disorder: For adults taking a starting dose of 1/2 tablet once a day, the dose can then be increased to 2 tablets/day, up to a maximum dose of 3 tablets/day. . In the treatment of generalized anxiety disorder: Adults take the starting dose of 2 tablets once a day. In the treatment of obsessive neurosis: Adults take the initial dose of 1 tablet/time/day. Therapeutic dose is 2 tablets/time/day. Maximum dose 3 tablets/time/day. In the treatment of social anxiety disorder: Adults starting dose of 1 tablet / time / day can then increase the dose to 3 tablets / time / day use. In the treatment of post-traumatic stress disorder or for the elderly, people with liver and kidney failure: Adults take the initial dose of 1/2 tablet / time / day, the next treatment time can be used according to the dose. As directed by the doctor, the maximum dose is 2 tablets / time / day.

When using an overdose, patients will experience some symptoms such as: changes in blood pressure, dilated pupils, headache, nausea, muscle contractions, agitation, tachycardia.
Treatment : There is currently no specific antidote for Brisdelle, but treatment is mainly based on the symptoms that the patient experiences. Specifically, maintaining the patient's breathing when the patient has breathing problems, ensuring oxygen and ventilation for the patient. In severe cases, it may be indicated to wash the intestines or induce vomiting, then give the patient 20-30g of activated charcoal after overdosing for 24 hours. Your doctor will order an electrocardiogram and monitor your heart's functions.

Common reactions when patients take drugs such as nausea, drowsiness, dizziness, trouble sleeping, loss of appetite, weakness, dry mouth, sweating, blurred vision, yawning.
Serious side effects such as tremors, restlessness, decreased sexual interest, impaired physiological function, numbness, tingling, easy bruising, bleeding, abnormally fast heartbeat, muscle weakness, contractions convulsions, convulsions.
Uncommon reactions such as serotonin syndrome, hallucinations, unusual restlessness, heart palpitations, severe dizziness, unexplained fever, nausea, vomiting, diarrhea, severe muscle convulsions.
Mania can occur in patients with depression and is most common in patients with bipolar disorder.

Use caution when administering the drug to patients with impaired liver and kidney function. Do not drink alcohol while taking medication. Be careful when using Brisdelle in patients with cardiovascular disease, epilepsy, history of obsessive-compulsive disorder. Patients should stop taking the drug when convulsions appear. For pregnant and lactating women: The drug can cross the placenta and into breast milk, so it must be considered when used for pregnant or lactating women. Breastfeeding. The drug should only be used in pregnant women when weighing the effectiveness of the drug with the unwanted side effects of Brisdelle. For women who are breast-feeding: Doctors recommend not to use the drug for these cases, if the patient uses the drug, the child should be closely monitored.

Brisdelle should not be taken with monoamine oxidase inhibitor antidepressants such as: Isocarboxazid, Phenelzine, Tranylcypromin and Procarbazine, the combination with these drugs can lead to side effects such as confusion, high blood pressure. , tremors and increased activity. This type of interaction also occurs with Selegiline, Feniramine, and Dexfenfluramine.
Cimetidine: The anti-ulcer drug Cimetidine increases the concentration of Paroxetine in the blood, which may lead to increased side effects of the drug. Warfarin: The component Paroxetine increases the risk of bleeding in patients taking Warfarin, although the mechanism of interaction is unknown. Tryptophan: Using together may cause headache, nausea, sweating and dizziness when taken with Brisdelle Phenytoin and phenobarbital : May decrease the amount of Paroxetine in the body, leading to a decreased effect of the drug. Using an NSAID non-steroidal anti-inflammatory drug such as Aspirin, Byprote Na proxen, Celecoxib, Diclofenac, Indomethacin, Meloxicam with Paroxetine may cause skin bruising or bleeding. Tricyclic antidepressants: Due to the interaction of these two drugs with each other, patients need to reduce the dose of both Brisdelle and tricyclic antidepressants such as Nortriptylline, Amitriptylline, Imipramine and Despiramine, and phenothiazine derivatives such as: Perphenazine and Class 1 C antiarrhythmics such as Propafenone and Flecainide and Metoprolol. Cimetidine: Paroxetine used with Cimetidine will increase the concentration of Paroxetine in the blood, so it is necessary to reduce the dose of Paroxetine. Procyclidine: When used together will affect the use of Procyclidine, so patients need to reduce the dose of Procyclidine. Use with alcohol: When the patient takes the drug and uses alcohol during treatment, it may increase some of the side effects of Procyclidine. Paroxetine. Hopefully with the sharing of the drug Brisdelle will help users understand the use and mechanism of action of the drug to get better treatment results.