Hepatitis B drug Entecavir: Uses, dosages, side effects

Entecavir is used for the treatment of chronic hepatitis B virus infection in adults and children 16 years of age and older with evidence of active HBV replication, elevated blood DNA-HBV and persistent elevations in serum aminotransferase levels. ALT or AST) or histological evidence of active liver disease.

Entecavir is a synthetic guanine derivative with activity against hepatitis B virus. It is phosphorylated by cellular enzymes to form an active metabolite, entecavir triphosphate. By competing with the natural substrate deoxyguanosin triphosphate, entecavir triphosphate inhibits human hepatitis B virus DNA polymerase, thereby blocking all stages of enzyme activity.
Indications for treatment with this Entecavir drug are based on histological, virological, biochemical, and serological responses in adults and children 16 years of age and older. Specifically:
Drugs used to treat chronic hepatitis B virus infection in adults and children 16 years of age and older with evidence of active hepatitis B replication, elevated DNA-HBV blood levels and persistent elevations in serum levels. serum aminotransferase (ALT or AST) or histological evidence of active liver disease.
Entecavir is contraindicated when:
There is a history of hypersensitivity to entecavir or to any component of the finished product. Women who are breastfeeding, pregnant and children under 16 years old.

Entecavir tablets (dose 0.5 mg or 1 mg) and solution form, dose for adults and children over 16 years old:
For decompensated liver disease: 1mg dose / time / day. Take the medicine before eating, or 2 hours after eating. For people with chronic liver disease who have been treated with Lamivudine: dose 1mg / time / day, take the drug before eating or on an empty stomach. For compensated liver disease and not treated with Nucleoside: 0.5 mg / time / day. Drink before or after meals. The duration of taking drugs to treat chronic hepatitis B can last 1 to 2 years, depending on the patient's condition. In decompensated cirrhosis or cirrhosis, discontinuation of entecavir is usually not recommended by the physician.

In rare cases, the hepatitis B drug entecavir can cause:
Lactic Acidosis: The telltale symptoms of lactic acidosis include: Numbness or coldness in the hands and feet; shortness of breath; muscle pain, muscle weakness; dizziness, frequent tiredness, or feeling weak; stomach pain causing nausea and vomiting; when measuring slow and irregular heart rate Mild fever: About 37.5 degrees C to 38 degrees C Psychiatric effects: Anorexia, insomnia, dizziness, headache Effects on the digestive system: dark urine, clay-colored stools, diarrhea. Jaundice, rash. Temporary hair loss Call your doctor or seek medical attention right away if you notice any of these side effects to take action.

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Customers can directly go to Vinmec Health system nationwide to visit or contact the hotline here for support.
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