Uses of Capime 1g

The main ingredient in the drug Capime 1g is Cefepime, this is a 4th generation Cephalosporin semi-synthetic antibiotic. It is effective against bacteria such as Enterobacteriaceae, Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Moraxella catarrhalis, Staphylococcus strains (except methicillin-resistant Staphylococcusaureus).
Capime 1g drug has antibacterial effect by inhibiting the synthesis of mucopeptides in the bacterial cell wall.
After intramuscular injection, Cefepime in Capime 1g is rapidly and completely absorbed. Peak serum concentrations are dose dependent and usually occur 30 minutes after injection. Cefepime then penetrates most tissues and fluids (such as bile, peritoneal, bronchial, and urine).
In the body, Cefepime is very little metabolized, only about 7% of the dose. The half-life of the drug is about 2 hours. Approximately 80% of an intravenous dose of Capime is excreted in the urine by glomerular filtration, with normal renal clearance of cefepime about 130 ml/min. 85% of the dose is excreted unchanged in the urine.

The drug is indicated in the following cases:
Severe urinary tract infections with complications including cases with associated pyelonephritis. Severe pneumonia includes cases associated with sepsis caused by strains of bacteria susceptible to the drug. Severe infections of the skin and skin structures caused by methicillin-susceptible strains of Staphylococcus aureus and by Cefepime-susceptible strains of Streptococcus pyogenes. Capime 1g is contraindicated in cases of hypersensitivity to Cephalosporin or L-Arginine antibiotics.
Use caution when using the drug in the following cases:
Patients with a history of anaphylactic reactions to penicillin, because about 5 - 10% of patients allergic to penicillin group antibiotics will have cross-allergies with penicillin. Cephalosporin antibiotics. In case of severe infections requiring beta-lactam antibiotics, cephalosporins can be used, but close monitoring is required and facilities are available to treat anaphylaxis. Reduce dose of Capime 1g in patients with renal failure. Capime 1g solutions should be visually inspected prior to injection for precipitation. Use caution when using Capime 1g for drivers or machine operators. The efficacy and safety of Capime 1g in children under 12 years of age have not been established. Capime can be used for pregnant women, but it is necessary to carefully consider the benefits for both mother and fetus before appointing. A small amount of Cefepime in the drug is secreted into breast milk. So there are three possible problems for a breastfed infant who is on medication: Changes in the microbiome in the gut. Direct effects of Capime drug on children. It interferes with the assessment of bacterial culture results that should be done when the child has a high fever. Therefore, it is necessary to monitor breastfed babies who are using Capime 1g.

3.1. Dosage The dose of Capime 1g should be according to the doctor's prescription, the reference dose for specific cases is as follows:
Adults and children > 12 years old:
Treatment of severe urinary tract infections with complications (including associated pyelonephritis), severe skin and skin structure infections: Use a dose of 2g/time intravenously, twice daily 12 hours apart, for 10 days. Treatment of severe pneumonia, including cases of associated sepsis: Use a dose of 2g/time, twice a day 12 hours apart, for 7-10 days. Patients with renal impairment (creatinine clearance < 60ml/min): Use the initial dose equal to the dose for patients with normal renal function. Calculation of the maintenance dose of Capime 1g according to the patient's creatinine clearance:
Creatinine clearance from 30 to 60ml/min: Use the normal dose for 24 hours. Creatinine clearance 10-30ml/min: Use 50% of normal dose for 24 hours. Creatinine clearance < 10 ml/min: Use 25% of normal dose for 24 hours. For patients on dialysis: Because 68% of Cefepime in the body will be lost after 3 hours of dialysis, after each dialysis, a dose equivalent to the initial dose should be used to compensate. For patients undergoing outpatient peritoneal dialysis: The usual dose should be administered every 48 hours. 3.2. How to use Capime 1g The drug can be used by slow intravenous injection for 3-5 minutes or intravenous infusion, or deep intramuscular injection.
Intermittent intravenous infusion: Mix 1 vial of Capime 1g into 10ml, 50ml or 100ml of intravenous infusion (can use Sodium chloride 0.9%, Dextrose 5%, Lactate ringer and 5%) injection solutions. to have a solution with the corresponding drug concentration of 100mg/ml, 20mg/ml or 10mg/ml. The required dose of Capime 1g will be calculated and added to the intravenous fluid. Perform intermittent intravenous infusion of Capime 1g over about 30 minutes. Intramuscular: Use 2.4 ml of a suitable solvent (such as distilled water for injection, Sodium chloride injection 0.9% solution, Lidocaine hydrochloride 0.5% or 1% solution, Dextrose 5%) into a vial containing contains 1g of Cefepime to form a solution with a drug concentration of approximately 280 mg/ml. Capime drug solutions 1g prepared for intramuscular or intravenous injection are stable for 18 hours at room temperature 20-25oC, if kept in the refrigerator 2-8oC, the drug will be stable for 7 days. Overdose of Capime 1g can be managed by artificial kidney dialysis or peritoneal dialysis: Dialysis in 3 hours will remove 68% of Cefepime in the body.

Common side effects of the drug include: Diarrhea, rash, injection site pain... Uncommon side effects of Capime 1g include: Fever, headache, eosinophilia, agranulocytosis , thrombophlebitis if administered intravenously, nausea, vomiting, reversible increase in liver enzymes.... Rare side effects of Capime 1g include: Anaphylaxis, dizziness, neutropenia. , low blood pressure, vasodilation, abdominal pain, joint pain... During the use of Capime 1g, if you notice any unusual symptoms, you need to stop the drug, immediately notify your doctor for treatment. timely handling.

Avoid concurrent use of Capime 1g with Furosemide, because it is easy to cause deafness. If it is necessary to use Capime 1g concurrently with Aminoglycoside drugs, Metronidazole, Ampicillin (at concentrations higher than 40mg/ml), Vancomycin or Aminophylline, these drugs must be infused separately.