Uses of Cefotalis

1 vial of Cefotalis contains 1g of Cefotaxime (as Cefotaxime sodium). Cefotaxime is a 3rd generation cephalosporin antibiotic with a broad spectrum of activity. Bacteria commonly sensitive to Cefotaxime include: Enterobacter, E.coli, Serratia, Shigella, P. mirabilis, P.vulgaris, Salmonella, Haemophilus influenzae, Haemophilus spp,... Cefotaxime resistant bacteria include: Listeria, Staphylococcus resistant to methicillin, Pseudomonas cepacia, Enterococcus, Xanthomonas hydrophila,...
Indications for the use of Cefotalis: Treatment of infections with microorganisms sensitive to Cefotaxime in:
Respiratory tract infections (including pneumonia); Infections of the urinary tract, genitals, gynecology, endometritis, urethral gonorrhea; Meningitis in children and adults; Late stage Lyme disease; Bone and joint infections; Abdominal infections; Sepsis ; Skin and soft tissue infections; Prevention of infection during surgery. Contraindications to the use of Cefotalis:
Patients with hypersensitivity to the components of the preparation, to cephalosporins and penicillins; People with a history of hemorrhagic disease (the drug can cause hypoprothrombinemia, possibly bleeding); Patients with a history of gastrointestinal disease, especially ulcerative colitis, colitis, regional colitis (because cephalosporins can cause pseudomembranous colitis).

How to use: Intramuscular or intravenous route.
Preparation: Add 5ml of sterile distilled water for injection, shake well until a clear solution is obtained.
Dosage:
Children: 50-100mg/kg every 8-12 hours; Adults: Take 1-2g every 6-8 or 12 hours. The maximum dose is 12g/day, divided into several doses. Overdose, missed dose: Cefotalis is administered by injection, under the supervision of medical staff, so overdose or missed doses are rare. If the patient has any unusual symptoms, they should immediately contact the doctor for timely and effective treatment.

When using Cefotalis, patients may experience some side effects such as:
Digestive: Nausea, diarrhea, pseudomembranous colitis; Hematology: Temporary decrease in white blood cells, temporary decrease in platelets, increased eosinophils; Renal: Temporary increase in blood urea and creatinine levels; Nervous: Headache, hallucinations, dizziness; Allergic reactions, especially anaphylaxis: Bronchospasm, hypotension, erythema multiforme, Stevens-Johnson syndrome, renal dysfunction, serum sickness-like reactions (joint pain, fever). , rash), convulsions (especially when taking high doses of the drug, in patients with renal dysfunction), thrombophlebitis; Other symptoms: Skin rash, fever, skin itching, hypoprothrombinemia, oral candidiasis, arrhythmia. Patients should inform their doctor about the side effects they experience when using Cefotalis for advice and guidance on the most appropriate treatment.

Some issues patients need to pay attention to before and while taking Cefotalis:
Cefotalis should only be used under strict medical control by medical staff; Before initiating therapy, the patient should be evaluated for a history of hypersensitivity reactions to cefotaxime, cephalosporins, penicillins or other drugs; Special care should be taken when using Cefotalis in patients who have had an allergic reaction to penicillin or to other beta-lactam drugs. Because of the potential for cross-allergic reactions between penicillins and cephalosporins, caution should be exercised when this drug is used in penicillin-sensitive patients; Cefotalis drugs when used prophylactically around surgery (before - during - after surgery) should usually be stopped 24 hours after surgery; During the use of Cefotalis, it is necessary to pay attention to the examination of liver function, kidney function and hematological parameters. A false-positive direct Coombs test reaction or a false-positive urinary glucose reaction with some routine tests (eg reduction reactions); There are no adequate studies on the efficacy and safety of Cefotalis in children, but no age-related problems have been found to date; Cefotalis has been used for the elderly and has not seen any age-related side effects. However, patients who are too old are prone to age-related renal dysfunction, so it is necessary to adjust the dose or widen the interval between doses to suit each other, as directed by the doctor; Prolonged use of Cefotalis can facilitate the growth of Candida albicans, causing candida in the mouth; Dosage of Cefotalis should be reduced in patients with impaired renal function; Cefotalis should not be used during pregnancy, when there is a chance of pregnancy or while breastfeeding. If it is necessary to use drugs in this group of subjects, a doctor's permission is required; Caution should be exercised when using Cefotalis when driving or operating machinery because the drug can cause side effects such as dizziness, headache,...

Drug interactions can affect the effectiveness of the treatment or increase the side effects of one/a few drugs. Therefore, patients should not arbitrarily start, stop taking, or change the dose of any medication.
Some drug interactions of Cefotalis include:
Concomitant use of Cefotalis with probenecid, aminoglycosides, potential diuretics (such as furosemide) may increase the risk of nephrotoxicity; Concomitant use of Cefotalis with alcohol may cause reactions similar to disulfiram such as abdominal or stomach cramps, nausea, vomiting, hypotension, headache, shortness of breath, palpitations, sweating, tachycardia, flushing,...; When Cefotalis is used concomitantly with coumarin or indandione-derivative anticoagulants, synthetic heparin or antithrombotic agents, Cefotaxime may inhibit vitamin K synthesis (by blocking enteric bacteria). When using Cefotaxime for a long time in very sick and malnourished patients, it is recommended to prevent it by using vitamin K; When Cefotalis is used concurrently with drugs that inhibit platelet adhesion, it may cause hypoprothrombinemia, increasing the risk of bleeding; When Cefotalis is used concurrently with Probenecid, Probenecid reduces the renal tubular excretion of Cefotaxime, leading to increased and prolonged serum concentrations of cephalosporins. Thereby, it increases the half-life of the drug, with a higher risk of toxicity. During the use of Cefotalis, the patient should absolutely coordinate with the doctor. At the same time, patients should share with their doctor about their medical history, the drugs they are using to make appropriate adjustments, and avoid dangerous drug interactions.