Uses of Cetabufen

Cetabufen is usually taken orally for pain relief and anti-inflammatory treatment for cases of rheumatoid arthritis, flu, rheumatism, headache, ... To ensure safety and soon be effective when When using Cetabufen, patients need to strictly follow the doctor's instructions on dosage, use, frequency and duration of use.

Cetabufen belongs to the group of analgesics, antipyretics and anti-inflammatory drugs, often used in cases of rheumatoid arthritis, menstrual pain, headache,... Cetabufen is manufactured by OPV Pharmaceutical Co., Ltd. Vietnam in the form of long tablets and packed in boxes of 10 blisters x 10 tablets.
Each Cetabufen tablet contains the main active ingredient, Ibuprofen, 200mg. In addition, the manufacturer also adds other auxiliary excipients in the tablets to help enhance the effect of the active ingredient Ibuprofen in the drug.

2.1. Uses of active ingredient Ibuprofen Ibuprofen in Cetabufen is a non-steroidal anti-inflammatory drug, belonging to the propionic acid subgroup and in the group of arylcarboxylic acid derivatives. When used in low doses, the active ingredient Ibuprofen provides fever-reducing and pain-relieving effects. If used at doses above 1200mg/day, Ibuprofen promotes effective anti-inflammatory activity. However, the antipyretic effect of this active ingredient is relatively poor, so it is rarely used as a simple antipyretic.
According to research, after only about 2 days of treatment, the analgesic and anti-inflammatory effects of Ibuprofen will be maximal. The anti-inflammatory mechanism of this active ingredient is based on its ability to inhibit the synthesis of an inflammatory mediator (Prostaglandin) through blocking the enzyme cyclooxygenase (COX). In addition, Ibuprofen also inhibits protein transformation, antagonizing the effect of some chemical mediators such as Serotonin, Bradykinin and Histamine. In addition, Ibuprofen stabilizes the lysosomal membrane, and inhibits the migration of leukocytes to infected tissues.
In terms of pain relief, Ibuprofen is similar to other NSAIDs. Ibuprofen's pain effect is usually mild - moderate thanks to the mechanism of reduction of Prostaglandin F2 synthesis, and at the same time reduces the accumulation of sensory nerve endings for substances that trigger pain. such as Serotonin, Bradykinin,... However, Ibuprofen's anti-platelet activity is weaker than that of Aspirin.
2.1. Indications – Contraindications to the use of Cetabufen Currently, Cetabufen is often prescribed by doctors to treat the following conditions:
Reduce fever and treat flu symptoms. Analgesic treatment for menstrual cramps, headaches and toothaches. Treatment of rheumatoid arthritis. Treatment of chronic rheumatic diseases. However, it is necessary to avoid arbitrarily using Cetabufen for the following subjects without specifically discussing with the doctor:
Patients with hypersensitivity or history of allergy to Ibuprofen or any of the excipients in the drug. Cetabufen is contraindicated in patients with advanced duodenal disease or gastric bleeding. Cetabufen should not be used in people with severely impaired kidney/liver function. Cetabufen is contraindicated in pediatric patients under 12 years of age. Cetabufen is contraindicated in pregnant women in the first and third trimesters of pregnancy. Relative contraindications to the drug Cetabufen for nursing mothers.

Cetabufen is available in the form of tablets for oral use. Patients should swallow the tablet whole and avoid drinking it with liquids other than water, such as coffee, milk, carbonated water, soft drinks, beer, wine, etc. effect of Cetabufen when used together.
Depending on the patient's health condition, the doctor will give specific indications on the dosage:
Pain relief and fever reduction: Use a dose of 200-400mg, can take a maximum dose of up to 1200mg / day. Treatment of dysmenorrhea: 400mg, taken 3-4 times a day. Treatment of mild-moderate pain: Oral dose of 400mg, used 4-6 times/day. Treatment of rheumatic diseases: Take the initial dose of 2400mg/day, then the maintenance dose from 1200-1600mg/day. Before using Cetabufen, patients should carefully read the leaflet that comes with the product or follow the instructions of the doctor. Avoid self-administering, adjusting the dose, or changing the duration of treatment with Cetabufen without consulting your healthcare provider.

In certain cases, Cetabufen may cause some adverse reactions to patients when used, including:
Gastrointestinal symptoms such as stomach pain, nausea, vomiting, Potential bleeding, dyspepsia, or peristalsis disturbances. Hypersensitivity skin reactions (rare) such as pruritus, rash, erythema, papules or edema. Respiratory system reactions such as asthma attacks, especially in people who are allergic to Aspirin, Ibuprofen or other non-steroidal anti-inflammatory drugs. Nervous system reactions (rare) such as dizziness or headache. Some side effects on liver, kidney or hematology such as transient increase in transaminase, renal failure, oliguria, hemolytic anemia or agranulocytosis. Side effects associated with Cetabufen may vary from patient to patient. Some mild symptoms will gradually disappear when the patient stops treatment, but a few rare cases associated with Cetabufen have the risk of other serious consequences and require urgent management. Ideally, when any adverse side effect occurs, the patient should notify the doctor as soon as possible so that there can be an early remedy.

Before starting treatment with Cetabufen, patients should note a few things below to ensure safety:
Caution when using Cetabufen for people at risk of peptic ulcers, high blood pressure or the elderly. . Cetabufen should be used with caution in patients with severe glaucoma, hepatic or renal impairment. The use of Cetabufen in people with high blood pressure or heart disease can lead to the risk of blood clots forming and causing other adverse reactions such as myocardial infarction, heart attack or stroke. Caution should be exercised when deciding to use Cetabufen for people with bleeding disorders, bronchial asthma, diabetes, severe liver/kidney dysfunction, thyroid disease. Glaucoma, diabetes or systemic lupus erythematosus. Cetabufen should be used with caution in patients with prostate enlargement or in late pregnancy. The risk of bleeding, perforation or peptic ulceration may occur when Cetabufen is given to people with stomach pain or stomach ulcers. Caution should be exercised when using Cetabufen for people whose work has to frequently drive vehicles, vehicles and machinery. Carefully check the expiry date and quality of Cetabufen before taking it. If the medicine has expired or shows signs of mold, changes in shape, color, ... the patient needs to discard the medicine immediately according to the instructions. In case of taking an overdose of Cetabufen and experiencing adverse effects, the patient needs to go to a medical facility immediately for treatment. For patients who have missed a dose of Cetabufen, it is important to take it as soon as possible, but avoid taking it at the same time as the next dose or taking a double dose.

Here are some drugs to avoid in combination with Cetabufen, including:
Other non-steroidal anti-inflammatory drugs, including high-dose salicylates, because this combination can cause synergistic effects and lead to bleeding or ulceration of the gastrointestinal tract. Oral anticoagulants, ticlopidine and parenteral heparin, when co-administered with Cetabufen, have a risk of bleeding due to the weakening of the gastric mucosa - duodenum and inhibition of platelet function. Lithium when taken with Cetabufen can increase the level of Lithium in the blood. Methotrxate increased hematological toxicity when co-administered with Cetabufen. Increased hypoglycaemic effect of sulphamides when used in combination with Cetabufen. Diuretics used together with Cetabufen can cause acute renal failure in dehydrated individuals due to impaired platelet filtration. Antihypertensive drugs may be less effective when taken with Cetabufen. Digoxin increased blood levels when combined with Cetabufen. Above is all information about Cetabufen, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Cetabufen is a prescription drug, patients need to use the drug as prescribed by the doctor, absolutely do not self-treat at home.