Uses of Daikyn

Daikyn belongs to the group of Hormonal - endocrine drugs, used in the treatment of endocrine disorders and estrogen deficiency. Let's learn about Daikyn drug information through the article below.

Daikyn medicine is made in the form of vaginal suppositories, with the main ingredient being Estriol 0.5mg and other excipients just enough for 1 tablet.
Estriol is one of the 3 main natural estrogens in women with the following effects:
Estriol has the effect of stimulating cell proliferation in the endometrium. But unlike other estrogens, estriol is short-acting because it stays for a short time in the nuclei of endometrial cells, so it is less likely to increase endometrial proliferation at the recommended daily dose. ; Estriol helps restore physiological pH and vaginal microflora, thereby helping to normalize and increase resistance to genitourinary epithelial cells, thereby helping to relieve unpleasant vaginal symptoms such as pain. burning, dryness, itching during intercourse, discomfort when urinating or incontinence, when having a vaginal or urinary tract infection. Therefore, the drug is especially effective in the treatment of atrophy of the lower genitourinary tract; Estriol also helps improve symptoms during menopause, replacing the decrease in estrogen production in these subjects.

Daikyn is commonly used to treat the following conditions:
Decreased estrogen in postmenopausal women as hormone replacement therapy (HRT); The environment in the cervix is ​​not suitable causing infertility; Treatment before and after vaginal surgery in postmenopausal women; Diagnostic aid in cases of suspected cervical cell atrophy.

Dosage of the drug depends on each case as follows:
Treatment of atrophy of the genital - urinary tract: In the first few weeks: Vaginal 1 tablet/time/day, daily use; When symptoms improve, the dose can be reduced until the maintenance dose is 1 tablet twice a week. Treatment before and after vaginal surgery in postmenopausal women: 2 weeks before surgery: Put 1 tablet/time/day, use daily; 2 weeks after surgery: Put 1 tablet / time, 2 times a week. Support diagnosis when cervical cell atrophy is suspected: Put 1 tablet / time / day, use every other day for 1 week before the next cervical smear. Use the lowest effective dose for the shortest duration in the treatment of postmenopausal symptoms. How to use Daikyn to achieve high therapeutic effect:
Wash the vagina with clean water or appropriate feminine hygiene solution, pat dry gently. The patient lies on his back, cushions under the buttocks, slowly put the medicine deep inside the vagina and lie still in place for 15-30 minutes; It is recommended to use it at night before going to bed to avoid dropping the medicine during daytime activities.

Do not use Daikyn in the following cases:
People who are allergic to any of the ingredients in the drug; People who are or have had a history of breast cancer or suspected breast cancer; People with existing or suspected estrogen-dependent malignancies (such as endometrial cancer); Unexplained vaginal bleeding; Untreated endometrial hyperplasia; People with thrombotic disease due to lack of protein C, S or antithrombin; People with a history or current state of venous thromboembolism (deep vein thrombosis, pulmonary embolism) or arterial thromboembolism (angina pectoris, myocardial infarction); Porphyrin metabolism disorders; People with impaired liver function.

When using Daikyn, you may experience some of the following side effects:
Nausea; Swelling, pain, breast tenderness; Bleeding, increased vaginal discharge; Itching, vaginal irritation after the injection; Venous and arterial thromboembolism; skin rash; Gallbladder disease ; Memory decline . During the use of the drug, if you see any serious abnormal symptoms, you should immediately contact your treating doctor or medical staff for timely treatment.

Possible interactions when using Daikyn with the following drugs:
Inducers of CYP450 enzymes (Phenobarbital and Phenytoin...), Rifampicin, Rifabutin... may increase metabolism Estrogen, therefore, will reduce the therapeutic effect of the drug.

When using Daikyn, caution should be exercised in the following cases:
For pregnant and lactating women: Using the drug for pregnant women may cause teratogenicity, the drug is excreted in breast milk, so the drug is excreted in breast milk. Do not use the drug on these subjects. There is no adequate evidence that the drug affects the ability to drive or use machines. Above is some information about the use of Daikyn medicine, if you need advice or have any questions, please consult a qualified doctor / pharmacist for answers.