Uses of Dihydroergotamine

Dihydroergotamine, also known as dihydroerogotamine mesylate, with active ingredient tamik, an alkaloid extracted from ergot mushrooms, has complex pharmacological effects. Dihydroergotamine has an affinity for both alpha-adrenegic and serotoninergic receptors, thus having both stimulant and inhibitory effects. In orthostatic hypotension, the drug Dihydroergotamine has a selective effect, causing vasoconstriction of the vessels containing the veins and venules with almost no effect on the resistance vessels such as arteries and arterioles. Increased venous tone leads to blood redistribution, which in turn prevents excessive accumulation of blood in the veins.
For migraine, the drug Dihydroergotamine has the effect of compensating for the lack of serotonin in the blood plasma and then by stimulating the effect of serotonin, so it counteracts the loss of tone of the extracranial vascular system, especially the vascular system. dilated scene. Therefore, to treat migraine, it is necessary to use dihyroergotamine with rapid action and long-term oral tablet in migraine prevention to stabilize the tone of the extracranial vasculature.

2.1 Indications for the use of Dihydroergotamine Drugs Indications for the use of Dihydroergotamine drugs for the following cases:
Orthostatic hypotension Primary or secondary hypotension Dizziness, prolonged fatigue Prevention and treatment of migraine , vasomotor headache Besides the above uses, Dihydroergotamine medicine may also be used to treat some other conditions that are not listed above. Therefore, before taking the drug, consult your doctor for advice and effective use of the drug.
2.2 Contraindication to the use of Dihydroergotamine The use of Dihydroergotamine is contraindicated in the following cases:
Patients with hypersensitivity to any component of the drug Diseases prone to vasoconstriction reactions such as peripheral and arterial disease coronary artery disease, especially unstable angina, shock, sepsis, vascular surgery, uncontrolled hypertension, severe liver and kidney failure. Pregnant and lactating women

Dihydroergotamine is available in the form of softgels and injections. The dose of Dihydroergotamine drug will depend on the patient's medical condition and age such as:
For the treatment of vasomotor headache, 1mg intramuscularly, then 1mg every 1 hour until the patient is sick. in remission or when a total dose of 3 mg is reached. For treatment of orthostatic hypotension with a dose of 4-30mg/day divided into several times. The usual dose is 3mg, taken three times a day, taken before meals. You need to take Dihydroergotamine regularly to get the most benefit from it. To take your medicine safely, take Dihydroergotamine exactly as directed by your doctor, do not use it more often, for less or for longer than prescribed. Absolutely do not abuse the drug for too long for a long time or arbitrarily increase the dose of the drug. Because this not only makes the condition worse, but also increases the risk of unwanted effects.

Some unwanted effects that may occur when using Dihydroergotamine include:
Dizziness Drowsiness Headache Nausea Diarrhea Sweating Muscle pain or weakness Itching Kidney damage Severe abdominal pain Low back pain Loss of sensation in fingers and feet Heart rhythm disturbances Before prescribing medication, doctors always weigh the benefits and effects of Dihydroergotamine more than the risk of side effects. However, in some cases, when taking Dihydroergotamine, unwanted effects may still occur. Therefore, when there are unusual signs after taking the drug, especially when a severe allergic reaction occurs with accompanying signs such as difficulty breathing, severe dizziness, swelling, rash or itching of the face area. , throat, tongue,... In this case, the patient should immediately notify the medical staff for immediate intervention.

Some notes when using Dihydroergotamine include:
Inform your doctor about a history of allergy to Dihydroergotamine or any other allergies. Dihydroergotamine may contain ingredients that are inactive and could cause allergic reactions or other serious problems. Report any medications you are taking including prescription and nonprescription drugs, herbs and supplements, foods, dyes or preservatives. Dizziness: If the patient drinks alcohol while taking the drug, it will make the dizziness worse. Do not drive, operate machinery, or do any activity that requires alertness until you are fully awake. Accordingly, patients should limit alcohol consumption, which is also a cause of headaches. Substances: Using drugs can increase your risk of serious side effects such as heart problems (chest pain, irregular heartbeat) and reduced blood flow to the brain and hands. , foot. Patients are not allowed to smoke, if they do not know how to quit smoking, they can ask their doctor for advice. If you forget to take a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue taking the medicine as scheduled. Do not arbitrarily use the drug twice the dose more than the treatment regimen. Using an overdose of Dihydroergotamine can cause serious symptoms such as nausea, vomiting, abdominal pain, weakness, ...

Drug interactions can decrease the effect of Dihydroergotamine, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including vitamins, over-the-counter medicines, prescription drugs, and herbal products. Do not stop, start, or change the dose of any medicine without your doctor's consent without your doctor's consent.
Some drugs that can interact with Dihydroergotamine include:
Vasopressors, sympathomimetic drugs: Concomitant use will increase blood pressure excessively. Beta-blockers: Due to reduced blood flow to the heart. Nicotine: This substance can cause ischemia in patients taking Dihydroergotamine. Macrolide antibiotics (erythromycin, josamycin, ..): Increases the toxicity of Dihydroergotamine, because this substance is accumulated in the body. In the Macrolide group, only Spiramycin and midecamycin did not have that effect. Glyceryltrinitrate (nitroglycerin): Concomitant use with Dihydroergotamine will inactivate each other. Because glyceryltrinitrate has a vasodilator effect. And dihyroergotamine causes vasoconstriction. Methysergid: increases the risk of arterial spasm.

Store Dihydroergotamine at room temperature, away from light and away from moisture. Do not store Dihydroergotamine in a humid place or in the freezer. Different medicines will have different storage methods, so read the Dihydroergotamine storage instructions on the package carefully, or ask your pharmacist. Keep Dihydroergotamine out of the reach of children and household pets. When the medicine has been damaged, it cannot be used anymore or has expired, please dispose of the medicine according to the correct procedure. Do not arbitrarily dispose of Dihydroergotamine into an environment such as a water pipe or toilet unless requested to do so. Please consult your waste disposal company or pharmacist on how to safely dispose of Dihydroergotamine to help protect the environment.
In summary, the drug Dihydroergotamine is used in the treatment of migraine, headache. However, Dihydroergotamine can cause some unwanted effects and drug interactions, so tell your doctor what medications you are taking to reduce the risk of side effects and increase effectiveness. for the treatment.
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