Uses of Exatus 200

Contains the main ingredient is Acetylcysteine ​​with a content of 200 mg - the N-acetyl derivative of L-cysteine, a natural amino acid. Exatus 200 is used to clear mucus and detoxify when overdose of paracetamol. In addition, the drug also reduces the consistency of sputum in the lungs, as well as a number of other conditions.

Exatus 200 is a brand name of the active ingredient Acetylcysteine ​​that is only used when prescribed by a doctor. The drug is a product of Euvipharm Pharmaceutical Joint Stock Company and is prepared in the form of film-coated tablets (box of 10 blisters, 10 tablets per blister).
Each Exatus 200 tablet contains 200mg of Acetylcysteine ​​and some other excipients just enough including: Microcrystallin cellulose, silica colloidal anhydrous, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide and talc.

The drug is used for two main purposes: expectorant and detoxifying when overdose of paracetamol. The drug reduces the viscosity of sputum in the lungs by cleaving the disulfide bridges in the mucoproteins and facilitates the expulsion of sputum by coughing or drainage or by mechanical means. Acetylcysteine ​​​​protects the liver in paracetamol overdose by maintaining liver glutathione concentrations, which is a necessary substrate to inactivate the intermediate metabolite of paracetamol which is toxic to the liver. Acetylcysteine ​​is converted to cysteine, which stimulates the liver to synthesize glutathione, thereby protecting the liver if treatment is started within 12 hours of paracetamol overdose.
After oral administration, acetylcysteine ​​​​is rapidly absorbed from the gastrointestinal tract, peak concentrations about 0.5 - 1 hour after oral doses of 200 to 600 mg. The half-life of Exatus 200 is approximately 6.25 hours.

Exatus 200 is indicated in the following cases:
Used as a mucolytic in mucoviscidosis such as cystic fibrosis of the pancreas. expectorant in respiratory diseases with thick mucus such as acute and chronic bronchitis. Routine cleaning in tracheostomy. Liver detoxification in case of paracetamol overdose. Dosage:
In adults and children from 7 years old and above: Take 1 tablet/time, 2-3 times/day. Dissolve the medicine in water and drink. At this therapeutic dose, the drug has absolutely no influence on the ability to drive and use machines. Liver detoxification in the treatment of paracetamol overdose: The initial dose is 140mg/kg, followed by a dose of 70mg/kg orally every 4 hours and a total of 17 times. Acetylcysteine ​​is most effective when taken within 8 hours of an overdose, after which time the effectiveness diminishes. For pregnant women: Should be used with caution because teratogenic effects are unknown. Treatment of paracetamol overdose with acetylcysteine ​​​​in pregnant women is effective, safe and has the potential to prevent liver toxicity in the fetus as well as in the mother. For breastfeeding women: The drug is safe to use. Before prescribing Exatus 200, tell your doctor if you have one of the following contraindications:
Hypersensitivity to acetyscysteine ​​​​or other ingredients of the drug. Have a history of asthma. One thing to keep in mind is that when using the drug, it is necessary to closely monitor patients who are at risk of asthma attacks or who have a history of allergies. Prophylaxis of bronchospasm is readily available with drugs such as salbutamol or ipratropium, and when spasms occur, acetylcysteine ​​should be discontinued.
In addition, caution should also be exercised in patients with a history of peptic ulcer because Exatus 200 can cause nausea, vomiting and gastric mucosal mucus loss.
Because of the expectorant effect through coughing, patients with reduced cough need to be assisted by suction or drainage.
When overdosing Exatus 200 will cause anaphylaxis-like symptoms and especially hypotension. In addition, it can cause other symptoms such as respiratory failure, hemolysis, disseminated intravascular coagulation and renal failure. Then, depending on the symptoms encountered, the treatment will be corresponding. However, the standard treatment is still according to the anaphylactic shock treatment protocol issued by the Ministry of Health of Vietnam.
Do not tear the medicine packaging, store at a temperature below 30oC and in a dry place, protected from light.

4.1 Drug Interactions Some products that may interact with Exatus 200 include: oxidizing agents (due to the reducing properties of acetylcysteine), other cough suppressants or any drug that reduces bronchial secretion ( can cause severe mucus congestion because of decreased cough reflex).
If the use of tetracycline is indicated, it should be separated from the time of taking acetylcysteine ​​at least 2 hours.
Furthermore, acetylcysteine ​​may potentiate the vasodilator and platelet aggregation inhibitory effects of nitroglycerin.
4.2 Side effects Acetylcysteine ​​has a wide safety margin, although clinically rare, bronchospasm can occur.
Possible side effects of Exatus 200 may include:
Nausea, vomiting. Tinnitus. Dizzy. Sleepy. Bronchospasm with systemic anaphylaxis (angioedema, rash and pruritus, hypotension or occasionally hypertension may occur). Fever. So cold. Anaphylaxis must be treated immediately according to the anaphylaxis management protocol of the Ministry of Health, by subcutaneous injection of adrenaline (0.3 - 0.5ml of 1/1000 solution), 100% oxygen breathing, intubation. Administer intravenous fluids if necessary, administer intravenous fluids, administer beta-adrenergic agonists if bronchospasm, intravenous 500 mg hydrocortisone or 125 mg methylprednisolone.
The above is information about the use of Exatus 200, patients need to read carefully the instructions for use before using the drug so that the medication process goes well and safely,