Uses of Febustad 40

Febustad 40 with the main ingredient is Febuxostat 40mg, used to treat chronic hyperuricemia in patients with gout. Febuxostat is not recommended for the treatment of asymptomatic hyperuricemia. Users of Febustad 40 drug should carefully read the instructions for use and strictly follow the indications given by the doctor to ensure high treatment effectiveness.

Febuxostat in Febustad 40 has the effect of reducing serum uric acid levels, effectively treating gout. The drug works by selectively inhibiting the activity of Xanthin Oxidase, an enzyme that catalyzes the conversion of Hypoxanthin to Xanthin and then to Uric Acid. Therefore, completely blocking the formation of uric acid in the serum without affecting other enzymes involved in the synthesis and metabolism of purine or pyrimidine.
Thanks to the above effect, Febustad 40 is indicated for use in the treatment of chronic hyperuricemia in gout patients. On the other hand, this drug is not allowed to be prescribed in the following cases:
The patient is hypersensitive to any of the ingredients of the drug. Do not use concomitantly with azathioprine, mercaptopurine, theophylline.

2.1. How to take Febustad 40 is in the form of film-coated tablets, which should be taken orally. It is recommended that patients only take the medicine with filtered or boiled water, avoid drinking with carbonated water, fruit juice, caffeine.
When taking the drug should swallow whole, do not break or crush unless directed by a doctor. Because if the drug is broken, the effect of the outer film coating will be lost. It is recommended to take the drug at any time of the day.
2.2. Dosage Depending on the health status and the concentration of uric acid in the blood, the patient is assigned to use the drug in an appropriate dose. The recommended dosage is as follows:
Initiation of treatment for high uric acid in patients with gout: Take 1 tablet once a day, once a day. After 2 weeks of treatment, control the blood uric acid concentration of the patient: If the serum uric acid level is not reached below 6mg/dL, the dose can be adjusted up to 2 tablets/time/day. In cases where serum uric acid levels are still greater than 6 mg/dL after 2-4 weeks of treatment, an increase in dose to 3 tablets once daily may be considered. To prevent recurrent gout attacks, it is recommended to use the drug for a minimum of 6 months. In elderly patients or those with mild hepatic impairment, mild to moderate renal impairment: No dose adjustment is required. No dose adjustment is required in patients with mild to moderate renal or hepatic impairment. Elderly people do not need to adjust the dose Children under 18 years of age need to consider carefully before prescribing. Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or healthcare professional.
Currently, no case of overdose of Febuxostat has been recorded. If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take double the prescribed dose.

Before prescribing medication, doctors always weigh the benefits and effectiveness of Febustad 40 more than the risk of side effects. However, some cases when taking Febustad 40 may still occur undesirable effects such as headache, diarrhea, nausea, impaired liver function, bile, rash, edema.
Some rarer side effects such as: hyperlipidemia, diabetes, insomnia, decreased sex drive, neurological disorders, irregular heartbeat, rapid pulse, respiratory depression...
Therefore, when If you have unusual symptoms, especially when a severe allergic reaction occurs, the patient should immediately notify a doctor or nurse for immediate medical intervention.

Febuxostat inhibits the enzyme Xanthin Oxidase, resulting in increased plasma concentrations of mercaptopurine, azathioprin and theophyllin, leading to altered toxicity. Therefore, the combination of drugs with these active ingredients should not be used. Glucuronosyltransferase, which may alter the elimination rate and bioavailability of Febuxostat. Therefore, closely monitor serum uric acid levels after 1-2 weeks of treatment with a potent glucuronidating agent. Drug interactions may decrease the effectiveness of Febustad 40 or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including over-the-counter medicines, vitamins, prescription drugs, and herbal products. Do not start, stop or change the dose of any medicine without your doctor's consent.

An increase in gout attacks upon initiation of anti-hyperuricemic agents, including Febuxostat. If a recurrent gout attack occurs during treatment, there is no need to discontinue Febuxostat. The incidence of cardiovascular thromboembolism was higher in patients treated with Febuxostat than with allopurinol in clinical trials. Liver failure may occur during the use of the drug. When signs of this condition appear, Febuxostat should be discontinued. Patients should be aware of and closely monitored for signs and symptoms of allergic/hypersensitivity reactions. Discontinue treatment with Febuxostat immediately if a severe allergic/hypersensitivity reaction such as Stevens-Johnson Syndrome occurs. Febuxostat 40 contains lactose and should not be used in patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Febustad 40 can cause some side effects such as dizziness, drowsiness... so patients who often operate machinery and drive should be cautious when using this drug. Women during pregnancy should only take Febuxostat when the potential benefits and risks to the fetus have been weighed. Lactating women should use caution when taking Febuxostat