Uses of Fonotim Tab

Fonotim Tab contains the main ingredient Nabumeton with a content of 500mg and excipients just enough for 1 tablet.
Effects of Nabumeton: Belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) with typical anti-inflammatory and analgesic effects. This substance acts as a precursor, when in the liver it will be oxidized to form 6-methoxy-2naphthylacetic acid, thereby inhibiting the formation of prostaglandins, which are mediators of inflammation. Therefore, this active ingredient will reduce the symptoms of pain and numbness caused by rheumatism.
In addition, Fonotim Tab also works on swelling and stiffness in the joints, especially in osteoarthritis, including acute and chronic.

2.1.Indications Fonotim Tab is used in the treatment of acute and chronic symptoms of chronic arthritis and rheumatoid arthritis (inflammation, swelling, stiffness and joint pain).
2.2.Contraindications Patients who are sensitive to Nabumeton or any other ingredient of the drug. Patients sensitive to Aspirin and other non-steroidal anti-inflammatory drugs: signs of asthma, nasal polyps, angioedema or urticaria. Patients with advanced peptic ulcer disease. Patients with liver failure, cystic heart failure. Children under 15 years of age Pregnant and lactating women

3.1. Dosage Adults
The usual starting dose is 2 tablets/day (equivalent to 1g content). In some cases, it is necessary to increase the dose to 1.5-2g/day to help relieve symptoms. Maintenance dose from 1-2g, but should not exceed 2g/day, can be used once or divided into 2 times/day. Patients weighing less than 50kg should not take more than 1g/day. Elderly
Use 1 tablet with a content of 500mg/day, it is recommended not to use more than 1g/day. Patients with renal impairment:
Creatinine clearance 50ml/min: no dose adjustment is required. Creatinine clearance 30-49ml/min: The dose should be reduced, starting with 750mg/day, increasing to a maximum of 1.5g/day. Creatinine clearance <30ml/min: Start dose with 500mg/day, increase to maximum 1g/day. 3.2. How to take Fonotim Tab is taken orally with a glass of filtered or boiled water. The recommended time to take the drug is in the evening before going to bed.

Overdose: If clinical signs of acute overdose of NSAIDs are lethargy, nausea, vomiting, epigastric pain, somnolence, gastrointestinal bleeding, hypertension, acute renal failure, depression If you have a cold or coma, the patient must be taken to the hospital immediately and carefully monitored and monitored for at least 24 hours. Monitor clinical signs, blood potassium levels and do liver and kidney tests. In case of serious overdose, hemodialysis should be performed on the patient to minimize dangerous complications.
Missed dose: Add dose as soon as you remember. However, if the interval between the next dose is too short, skip the missed dose and continue taking it as scheduled. Do not take a double dose for the missed dose.

Some common side effects when taking Fonotim Tab:
Digestive system: Indigestion, nausea, vomiting, constipation, abdominal pain, flatulence, belching, diarrhea, peptic ulcer, bleeding Digest. Skin and Subcutaneous Structures: Pruritus, rash, urticaria. Vision: Conjunctivitis, visual disturbances. Kidneys: Interstitial nephritis, nephritic syndrome and renal failure. Nervous system: Headache, dizziness, tinnitus, fatigue. Respiratory: Onset of acute asthma attack. Hematology: Causes anemia, blood count disorders, leukopenia, thrombocytopenia. Cardiovascular: Edema, hypertension, lower extremity edema, tachycardia. Liver: Temporarily increases transaminases. Allergies: Asthma, difficulty breathing, bronchospasm.

Some possible drug interactions Fonotim Tab may occur as follows:
Avoid taking 2 or more non-steroidal anti-inflammatory drugs at the same time, because there is a risk of increased effects and unwanted reactions. Antihypertensives: Fonotim Tab reduces the effectiveness of medicines for high blood pressure. Diuretics: Potential nephrotoxicity of non-steroidal anti-inflammatory drugs. Cardiac Glycosides: Exacerbation of heart failure, decrease in glomerular speed and increase in plasma glycoside concentrations. Fonotim Tab reduces the elimination of lithium and methotrexate, increases the toxicity of cycloporin to the kidneys. When taken with food or milk, Fonotim Tab is more rapidly absorbed, but the total amount of their metabolites in the blood remains unchanged.

During the use of Fonotim Tab, patients should note the following:
Do not use in the first 3 months of pregnancy and when breastfeeding. Caution should be exercised in patients with upper gastrointestinal disease or on anticoagulant therapy. Patients should stop taking the drug if there are signs of ulceration or gastrointestinal bleeding. Patients with renal failure, severe liver failure. Special care should be taken in patients who are sick or have a history of bronchial asthma, because the drug can aggravate bronchospasm. Caution in congestive heart failure, high blood pressure because the drug causes fluid retention and causes edema. For patients with kidney failure, heart failure, liver failure, taking diuretics and the elderly, it is necessary to monitor kidney function when taking Fonotim Tab. Drugs that increase serum transaminases or other functional indices. Sometimes the drug Fonotim Tab causes headache, dizziness, tinnitus, drowsiness, fatigue, so caution should be exercised when using the drug for those who drive and operate machinery. Fonotim Tab contains Nabumeton as the main ingredient. Fonotim Tab is used in the treatment of acute and chronic symptoms of chronic arthritis and rheumatoid arthritis. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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