Uses of Hasitec 10

Hasitec 10 is a medicine that helps lower blood pressure, used to treat high blood pressure and reduce the risk of effects of high blood pressure on the heart, brain and especially the kidneys. Hasitec 10 can be used alone or in combination with antihypertensive drugs to increase the effectiveness of hypertension treatment.

Hasitec 10 drug has the main ingredients Enalapril maleate 10mg and excipients just enough 1 tablet (excipients include: Lactose monohydrate, corn starch, croscarmellose sodium, gelatinized starch, sodium hydrocarbonate, magnesium stearate). The drug is in the form of tablets. Enalapril is an angiotensin-converting enzyme inhibitor (ACEi) medication. After oral administration, Enalapril is converted to Enalaprilat, a substance that inhibits the conversion of angiotensin I to angiotensin II. Angiotensin II is a strong vasoconstrictor and activates the water retention and salt retention effects of Aldosterone, thereby causing an increase in blood pressure, which is the main mechanism causing hypertension.
In hypertensive patients when using Enalapril has the effect of lowering blood pressure by reducing peripheral resistance, causing dilation of both arteries and possibly veins.
In patients with congestive heart failure: Enalapril is used in combination with cardiac glycosides and diuretics to reduce total peripheral resistance, pulmonary artery pressure and heart size, and arterial pressure and heart rate. right atrial pressure. In patients with diabetes and kidney disease: Helps to reduce proteinuria and increase insulin sensitivity. It helps slow the progression of kidney failure in people with diabetes and kidney disease. Because bradykinin inhibits the breakdown of bradykinin, it causes stagnation in the lungs, which may be a factor in the patient's cough when taking the drug.

2.1 Indications Hasitec 10 is indicated for the treatment of:
Idiopathic or secondary hypertension. Heart failure: Helps to reduce mortality and complications in patients with symptomatic heart failure and asymptomatic left ventricular dysfunction. Treatment after myocardial infarction. Diabetic nephropathy with or without hypertension. Chronic progressive renal failure. 2.2 Contraindications Do not use Hasitec 10 in the following cases:
The patient has a history of hypersensitivity to any ingredient of the drug. Angioedema occurs at the beginning of treatment with ACE inhibitors. Or have idiopathic angioedema. Bilateral renal artery stenosis or renal artery stenosis in a patient with 1 kidney. Aortic stenosis and obstructive cardiomyopathy. Patient has low blood pressure.

Usage: The drug is indicated for oral use. You can take the medicine at any time, but it is recommended to take it in the morning and it needs to be taken at the same time of day for it to be effective.
Dosage: The dose of the drug is adjusted to suit the condition of each patient.
Idiopathic hypertension:
The starting dose is usually a low dose of 2.5 - 5mg/day, to avoid excessive lowering of blood pressure. Maintenance dose is usually 10-20mg/time/day, dose adjusted according to individual response. The maximum dose used to treat hypertension is 40 mg/day. If the patient is taking diuretics: Diuretics should be stopped 1-3 days (if possible) or used every other day before Enalapril to avoid excessive hypotension. Then start the starting dose: ≤ 5mg/time/day. The dose should be gradually increased cautiously according to the patient's response and tolerability and re-incorporated diuretics as needed. Heart failure:
The first week: Take the first 3 days with a dose of 2.5mg / time / day, the next 4 days take a dose of 2.5mg / time x 2 times / day. Then gradually increase the dose over 2-4 weeks to reach a maintenance dose of 20mg/day, administered once or in two divided doses morning and evening. In some special cases, the patient can increase the dose to a maximum of 40mg/day. Asymptomatic left ventricular dysfunction:
Initial dose: Take 2.5mg/time x 2 times/day in the morning and evening. Adjust dose accordingly, may increase gradually after about 2-4 weeks of treatment to maintenance dose up to 20mg/day. Diabetic kidney disease:
Initial dose: Take 5mg/time/day. Maintenance dose: 10-40mg/day, taken 1 or 2 times a day. It depends on the patient's response and tolerability. Renal impairment: Reduce dose or extend the interval between therapeutic doses depending on creatinine clearance
Creatinine clearance 30-80ml/min: Initial dose 5-10mg/day. Creatinine clearance 10-29ml/min: Initial dose 2.5-5mg/day. Creatinine clearance <10ml/min: Initial dose is 2.5mg/day. How to handle when patients forget dose, overdose
Missed dose: The drug is usually used once a day, so avoid forgetting the dose. If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not take a double dose to make up the dose. Schedule an appointment to avoid missed doses. Overdose: The symptom of an overdose is an excessive drop in blood pressure. Treatment: It is necessary to stop the drug, apply symptomatic and supportive measures such as induction of vomiting, gastric lavage, and intravenous fluids to maintain blood pressure and electrolyte balance. Hemodialysis may be necessary to remove Enalapril from the circulation.

Hasitec 10 side effects have been reported including:
Common side effects:
Headache, dizziness, feeling tired, insomnia, paresthesia, sensory disturbance. Taste disturbance, abdominal pain, diarrhea, nausea, vomiting. Rash. Dry cough: This is a common side effect of antihypertensive drugs of the ACE inhibitor class, but it is necessary to rule out the cause of an upper respiratory tract infection. Sometimes a patient coughs so much that it requires a change in medication or dosage. Renal failure, angioedema, orthostatic hypotension, syncope, palpitations, chest pain. Hypotension: Excessive hypotension may occur when using Enalapril at a dose of 10mg. Careful monitoring is required when using the drug, especially in high-risk people such as the elderly, dehydrated, and salt-depleted. When taking Hasitec, there may also be other side effects not mentioned above. If you experience unwanted effects, you should immediately notify your doctor or pharmacist for guidance on reasonable and timely treatment.

Before taking the drug, it is necessary to inform the doctor about the history of allergies and medical conditions in order to be able to use the drug safely.
When indicated you need to take the medication continuously and monitor your blood pressure. If abnormality occurs or blood pressure is not controlled, you should notify your doctor for treatment.
Precautions when using the drug:
Pregnant women: Using Hasitec in the first 3 months and the end of pregnancy can cause stillbirth, neonatal damage due to Enalapril causing hypotension. Do not use while pregnant, if you intend to become pregnant or find out that you are pregnant, you should immediately stop taking the drug and consult a doctor to be prescribed the appropriate drug. Lactation: Enalapril may be excreted in breast milk. At therapeutic doses no adverse effects on the nursing infant were shown. However, caution should be exercised when using this product. People who drive and operate machinery: When used, the drug can cause dizziness and lightheadedness. Use caution when driving or operating machinery. Patients with impaired renal function: If in 4 weeks of treatment with blood pressure medicine Hasitec 10 but there is no clinical improvement, the dose should be increased or used another antihypertensive drug to avoid kidney damage. Patients with renal artery stenosis: When taking the drug, it is necessary to measure plasma creatinine before using Enalapril. Patients with unexplained left ventricular dysfunction when taking the drug should closely monitor blood pressure, kidney function before and after using the drug; Monitor serum potassium levels. Patients with heart failure grade 4, electrolyte disturbances: Monitor carefully when taking the drug. When taking the drug, it is necessary to follow a healthy diet such as reducing salt, reducing fat, processed foods, increasing green vegetables and fruits. Exercise regularly according to health. This helps to promote health, minimizes the need to take combination antihypertensive drugs due to uncontrolled blood pressure.
To avoid excessive lowering of blood pressure when taking the drug, the doctor recommends that patients take the first dose in the evening before going to bed. Then adjust the time accordingly. If excessive hypotension occurs, you should lie down, keep your head low and monitor, if it does not improve, you need to go to a medical facility immediately.
Drug interactions: Possible drug interactions that you need to be aware of include
Other vasodilators, anesthetics: Concomitant use with Enalapril can cause severe hypotension. Diuretics: Occasionally causes excessive hypotension when initiating treatment with Enalapril. Drugs that cause renin release: This increases the effect of Enalapril which can also cause hypotension. Potassium-sparing diuretics, potassium supplements, potassium-containing salts: Causes an increase in blood potassium levels, especially in patients with renal failure. Hyperkalemia is very dangerous, affects heart rate and needs to be treated. You must control the amount of potassium in your body to avoid causing high blood pressure. Lithium: Increases blood levels of Lithium, which can lead to lithium toxicity. Sympathomimetic bronchodilators, nonsteroidal anti-inflammatory drugs (NSAIDs): What reduces the antihypertensive effect of Enalapril. Birth control pills: Increased risk of damaging blood vessels and making it difficult to control blood pressure. Above is the information about the drug Hasitec 10, if you do not understand clearly about the drug, you can consult your doctor. Adhere to treatment to reduce the risk of harm to the body and best control blood pressure.