Uses of Hesperidin

Hesperidin contains the active ingredient Hespiridin, which has the effect of protecting the vascular wall and increasing venous tone. The drug is indicated in the treatment of hemorrhoids, varicose veins. Let's find out the dosage and notes when using Hesperidin through the article below.

1. Uses of the drug Hesperidin

1.1. Point

The use of Hesperidin is to protect the vascular wall and increase venous tone. Therefore, the drug is indicated in the treatment of venous circulation disorders (irritated pain, swelling of the legs), treatment of symptoms of chronic hemorrhoids, acute hemorrhoids.

1.2. Pharmacodynamic

Active ingredient Hesperidin belongs to the group of flavonoids, which are abundant in the white membrane and outer peel of citrus fruits. Hespiridine is also known as a flavonoid-7-O-glycoside with a phenol structure containing a flavonoid base.
Hespiridine has the effect of platelet adhesion, increasing vascular permeability. This effect is important because it helps the vessel wall to be more stable, against vascular disorders such as myocardial infarction, atherosclerosis, phlebitis causing pain in the limbs and hemorrhoids. In addition, Hespiridine contributes to the reduction of symptoms of brain diseases such as Alzheimer's, dementia, Parkinson's disease,...
The effect of the drug on the venous system through the following mechanism:
On the venous system : Reduce stagnation, reduce the tension of veins. On microvascular circulation: Increases capillary strength, helps to normalize capillary permeability.

1.3. Pharmacokinetics

Absorption: Hespiridine is passively absorbed from the intestine into the systemic circulation.
Metabolism: Hespiridin is hydrolyzed by alpha - arhamnosidase and beta - glucosidase microorganisms in the colon before absorption.
Elimination process: The drug is excreted mainly in the feces, about 14% of the dose is excreted in the urine. The half-life (t1/2) of Hespiridine is approximately 11 hours.

2. Dosage of the drug Hesperidin

The dose of Hesperidin depends on the age and condition of the patient. Specific recommended doses in adults are as follows:
Varicose veins: Take 1 tablet x 2 times/day at noon and in the evening. Acute hemorrhoids: Take 6 tablets/day for the first 4 days, the next 3 days take 4 tablets/day and maintain the dose of 2 tablets/day. Chronic hemorrhoids: Take 2 tablets/day

3. Side effects of the drug Hesperidin

Some of the side effects that may be encountered when using Hesperidin are as follows:
Common side effects: Nausea, vomiting, indigestion, diarrhea. Rare side effects: Colitis, headache, dizziness, malaise, itching, rash, itchy papules. Side effects of unknown frequency: Localized facial edema, abdominal pain, eyelid swelling, lip swelling, Quincke edema (sudden swelling of lips, face, tongue, mouth or throat causing difficulty breathing).

4. Precautions when using Hesperidin

4.1. Contraindications

Contraindicated for use in patients allergic to any ingredient of Hespiridine.

4.2. Note when using

Patients with acute hemorrhoids, if after treatment with Hespiridine within 15 days, the symptoms do not improve, they should consult their doctor again. Patients with chronic venous insufficiency when treated with Hespiridine should combine with postural therapy, change risk factors such as limiting standing, sitting for too long, avoiding sun exposure and heat, Regular exercise such as cycling, walking, dancing, wearing elastic stockings,... Obese patients need to exercise in combination with a reasonable diet to lose weight.. Pregnant women: There are no reports of hespiridine effects on the fetus. However, the patient should inform the doctor when pregnant, especially in the first 3 months of pregnancy. Lactation: There are no studies demonstrating the excretion of the drug in breast milk. Therefore, patients should not breast-feed during treatment with the drug. Ability to drive and use machines: The drug does not affect the ability to drive or use machines.

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Bài viết này được viết cho người đọc tại Sài Gòn, Hà Nội, Hồ Chí Minh, Phú Quốc, Nha Trang, Hạ Long, Hải Phòng, Đà Nẵng.