Uses of Hwadox Inj

Hwadox Inj has the main ingredient Cefepim (in the form of Cefepime Hydrochloride), which is a 4th generation cephalosporin antibiotic with a broader spectrum of action than 3rd generation Cephalosporins. Let's find out what Hwadox does through the article below.

Hwadox Inj has the main ingredient Cefepim (as Cefepime Hydrochloride), which is a 4th generation cephalosporin antibiotic with a broader spectrum of action than 3rd generation Cephalosporins. The drug is indicated for the treatment of a wide variety of infections caused by bacteria by bactericidal effect through inhibition of bacterial cell wall synthesis. Hwadox Inj is prepared in the form of a vial of powder for injection, each vial contains 1g of Cefepim.

The drug is used to treat very severe infections, sensitive to Cefepim:
Severe urinary tract infections with complications. Pyelonephritis. Hospital-acquired pneumonia, community-acquired severe pneumonia. Severe infections of the skin and subcutaneous tissues. Meningitis . Sepsis . Complicated intra-abdominal infections (or in combination with intravenous metronidazole). Adults and children over 2 months of age with fever accompanied by neutropenia.

Absolutely do not use Hwadox Inj in patients who are sensitive to Cefepime or any other component of the drug or other Cephalosporin antibiotics; Patients with a history of allergy or hypersensitivity to other penicillins or beta-lactams.

Hwadox Inj is produced in the form of a vial of powder for injection and infusion. Note, Hwadox Inj is a prescription drug, patients need to use the drug as prescribed by the doctor and absolutely must not mix drugs or infuse at home, but need to go to a quality medical facility for examination and treatment. medical - the doctor who executes the medicine order. Hwadox Inj is used for injection, intravenous infusion or intramuscular injection.
Depending on the patient's infection status, Hwadox Inj is indicated for deep intramuscular injection, slow intravenous injection over 3 - 5 minutes of a solution containing 100mg/ml or intermittent intravenous infusion over a period of time. 30 minutes. Hwadox Inj intramuscularly only for mild and moderate infections or when the intramuscular route of administration is more suitable for the patient.

Dosage of Hwadox Inj drug may change depending on factors such as: age, weight, patient's infection status, drug history, special circumstances (patients with renal failure, pregnant and lactating women). Therefore, patients should use the drug dose as prescribed by the doctor, not arbitrarily increase or decrease the dose of the drug. Refer to the dosage below:
Adults
Severe abdominal infections: Intravenous 2g / time x 2 times / day (each injection is 12 hours apart), lasts for 7-10 days. Often combined with the antibiotic Metronidazol for treatment (Metronidazole infusion separately). Nosocomial pneumonia: Dosage 1-2g/time x 2-3 times/day (each injection is spaced 8-12 hours apart). Duration of treatment can vary from 7 to 21 days and is usually prolonged if the patient has Pseudomonas infection. Community-acquired pneumonia: Dosage 1-2g / time x 2 times / day (each injection is 12 hours apart), using the drug for 10 days. Skin and subcutaneous tissue infections (uncomplicated): Use intravenous dose of 2g / time x 2 times / day (each injection is 12 hours apart), using the drug for 10 days. Urinary tract infections (with or without complications): In case of mild to moderate disease, use intramuscularly or intravenously at a dose of 0.5 - 1g/time x 2 times/day (each injection at intervals of time). 12 hours apart), used for 7-10 days. In case of severe disease: Intravenous dose of 2g / time x 2 times / day (each injection is 12 hours apart), using the drug for 10 days. Purulent meningitis and CNS damage caused by susceptible bacteria: Intravenous dose of 2g x 3 times/day (8 hours apart). Duration of treatment depends on individual patient response. For infections caused by H. Influenzae, N. meningitidi, the duration of treatment should be 7 days, for S. pneumoniae, 10-14 days, and 21 days for anaerobic Gram-negative bacteria. Fever with neutropenia (monotherapy): Intravenous dose of 2g x 3 times/day (each dose is given at 8 hour intervals), continue for 7 days or until blood tests subside. neutrophil. Brain abscess, prevent infection after neurosurgery: Dosage: 2g/time x 3 times/day (each dose is given 8 hours apart), usually used in combination with antibiotic vancomycin (dose 500mg/time, every 8 hours) disposable hours). Children:
Skin and subcutaneous tissue infections (uncomplicated) and pneumonia: Intravenous dose of 50mg/kg/time x 2 times/day (each injection 12 hours apart), duration of drug lasts for 10 days. Fever with neutropenia: Intravenous dose of 50mg/kg/time x 3 times/day (each dose is given 8 hours apart), continue for 7 days or until blood test clears neutropenia. count. Urinary tract infections with or without complications: Use intramuscularly or intravenously at a dose of 50mg/kg/time x 2 times/day (each dose is given 12 hours apart), using the drug for 7-10 days. . Purulent meningitis and CNS damage caused by susceptible bacteria: Children over 2 months old to 15 years of age should use the drug at a dose of 50mg/kg/time x 3 times/day, (each dose is given 8 times apart). hours), taking the drug for 7-10 days. The duration of treatment is based on the individual patient's response to treatment. For infections caused by H. Influenzae, or N. meningitidis, the recommended duration of treatment is 7 days, for S. pneumoniae is 10-14 days and for gram-negative anaerobic bacteria is 21 days. Other subjects:
Patients with renal failure: Need to adjust the drug dose according to Creatinine clearance (ClCr).
Patients with renal failure with creatinine clearance (ClCr) 30 - 60ml/min: Use the initial dose equal to the dose for people with normal renal function. Patients with renal impairment with creatinine clearance (ClCr) 10 - 30 ml/min: The dose in 24 hours is 50% of the usual dose. Patients with renal impairment with creatinine clearance (ClCr) < 10ml/min: The dose in 24 hours is 25% of the usual dose. Patients on hemodialysis receive a first dose of 1g Hwadox Inj once daily, followed by 500mg once daily for the treatment of common infections or 1g once daily for infections in patients with fever accompanied by neutropenia.

Patients using Hwadox Inj may experience some unwanted side effects as follows:
On the skin and systemic reactions: Irritation at injection site, itching, rash, maculopapular rash, fever, Quincke's edema (edema of the face, edema of the pharynx and vocal cords). Rare: Stevens-Johnson syndrome, toxic skin necrosis. Digestive system: Oral candidiasis, nausea, vomiting, diarrhea, abdominal pain, pseudomembranous colitis. On the liver: increased liver enzymes. Nervous system: Dyspnea, tremor, neuromuscular excitability, dizziness, confusion, hallucinations, convulsions, headache. Blood and Lymphatic System: Thrombophlebitis (if intravenous), eosinophilia, granulocytopenia, lymphocytosis, possibly positive direct Coombs test without true hemolysis. Renal - urinary and genitourinary systems: Increase in blood urea and creatinine, vaginitis, decrease in creatinine clearance (ClCr).

When using Hwadox Inj, the following should be cautious:
Due to cross-reactivity between penicillins and cephalosporins, the patient needs to inform the doctor about his/her allergy history to antibiotics. Penicillin or any other medication if available, and any medications the patient was currently taking before starting treatment with Hwadox Inj. It is necessary to reduce the dose of Hwadox Inj in patients with renal impairment because the drug can reduce the glomerular filtration rate. Hwadox Inj solutions should be visually inspected prior to injection for precipitation in the infusion line or syringe. Long-term use of antibiotics, including Hwadox Inj, can cause bacterial superinfection, fungal infection or the proliferation of bacterial infections, including Clostridium difficile infection associated with diarrhea and inflammation. pseudomembranous colon. Use caution when using Hwadox Inj in patients with neuropsychiatric diseases because some Cephalosporin antibiotics (including Hwadox Inj) have the potential to cause seizures and convulsions, especially in patients with impaired renal function. decreased without dose adjustment of Hwadox Inj. Hwadox Inj should be used with caution in patients with a history of convulsions, especially in patients with renal impairment because of the possible increased risk of convulsions. During treatment with Hwadox Inj, if a patient develops convulsions, Hwadox Inj should be discontinued immediately and appropriate antiepileptic drugs used. The efficacy and safety of Hwadox Inj in neonates and infants under 2 months of age have not been established. Use in Pregnancy: Studies in experimental animals have not shown that Hwadox Inj has a toxic effect on the fetus. However, there are no adequate and well-controlled studies on the use of Hwadox Inj for pregnant women, therefore, only use Hwadox Inj for pregnant women when prescribed by a doctor with greater benefits. Risks of using Hwadox Inj. For women who are breastfeeding: Hwadox Inj is excreted in small amounts into breast milk, causing unwanted side effects for the baby. Therefore, breastfeeding should be discontinued in mothers taking Hwadox Inj. For people who are driving or operating machinery: Be careful when using Hwadox Inj for drivers, operating machinery or when doing work that requires alertness because Hwadox Inj may cause side effects such as dizziness. , headache, tiring. Hopefully the above information will help patients better understand the uses and problems encountered when using Hwadox Inj. Note, Hwadox Inj is a prescription drug, the patient needs to use the drug as prescribed by the doctor, absolutely do not self-inject the drug at home. If the patient has any questions about Hwadox Inj, you can contact Vinmec to receive advice from a team of highly qualified doctors and pharmacists.