Uses of Midapezon

Midapezon drug is used in the treatment of infections caused by susceptible bacteria such as: Infections of the respiratory tract, urinary tract, genitals, ... Midapezon has the main ingredients Cefoperazone and Sulbactam. Let's learn more about the Midapezon drug line through the following article.

Midapezon drug belongs to the group of drugs for parasites, anti-infectives, antivirals, antifungals. Midapezon is prepared in the form of a powder for injection, packed in a box of 1 bottle of 20ml capacity and a box of 10 bottles of 15ml capacity.
Midapezon drug has the main ingredient is Cefoperazone (as Cefoperazone sodium) with the content of 0.5 g and Sulbactam (as sulbactam sodium) with the content of 0.5 g along with other excipients in the drug.

Cefoperazol and sulbactam injections are indicated for the treatment of infectious diseases caused by susceptible microorganisms:
Upper respiratory tract infections Lower respiratory tract infections Urinary tract infections. Peritonitis, cholangitis, cholecystitis, other intra-abdominal infections. Blood infections Meningitis Skin and soft tissue infections Bone and joint infections Pelvic infections, gonorrhea, endometriosis Other genital infections.

Midapezon can be administered intramuscularly or intravenously.
The recommended adult dosage of Midapezon is as follows:
Mild and moderate infections: Take the recommended dose of 1-2g Cefoperazone every 12 hours. Severe infections: The recommended dose is 2-4g of Cefoperazone every 12 hours. The usual dose of Midapezon in children:
The recommended dose is 25-100mg of Cefoperazone/kg every 12 hours. Renal impairment: No dose reduction of Cefoperazone is required.
Dosage for people with liver disease or biliary obstruction should not take more than 4g of Cefoperazone/24 hours.
Cases of overdose with Midapezon:
Data on acute toxicity of cefoperazone and sulbactam in humans are limited. Side effects have been reported with an overdose of Midapezon. High levels of β-lactamase antibiotics in the patient's cerebrospinal fluid can cause side effects such as seizures and should be carefully monitored. In the event that Midapezon overdose occurs due to renal failure, hemodialysis can remove cefoperazone and sulbactam from the body.
Symptoms of overdosage with Midapezon have been reported, including increased neuromuscular excitability and convulsions, especially in patients with renal impairment.

Midapezon should not be used in cases where the patient has a history of allergy to sulbactam antibiotics, cefoperazone, penicillin, or any antibiotic of the cephalosporin group.

Drinking alcohol or alcohol-containing products in combination with the drug Midapezon can cause accumulation in the blood, causing a reaction similar to disufiram, causing inhibition of aldehyde dehygrogenase. Typical symptoms such as hot flashes, sweating, headache, and tachycardia have been reported with alcohol consumption during treatment, or after 5 days of taking Midapezon. Similar reactions occur when other cephalosporin antibiotics are used; cefoperazone and sulbactam should be used with caution with alcoholic drugs.
Do not share Midapezon with aminoglycoside antibiotics, because it will reduce the activity of the drug, due to the physical incompatibility between them. When sulbactam and cefoperazone are used in combination with aminoglycosides, the infusion should be interrupted and the infusion tube washed between the two doses. Or take aminoglycosides away from sulbactam and cefoperazone.
Lindocaine in combination with Midapezon : It is not recommended to make the initial reconstituted solution with 2% lindocaine HCl solution, because these suspensions are incompatible. Sterile distilled water was used to make the initial reconstituted solution and diluted with 2% lidocaine to make a compatible solution.
Be careful when combining Midapezon with thrombolytics, anticoagulants, non-steroidal anti-inflammatory drugs because of the potential for bleeding.
Midapezon should not be mixed with gentamicin, amikacin, ketamycin B, doxycynlin, ajmalin, meclofenoxate, diphenhydramine, potassium magnesium aspartate to avoid precipitation. When mixed with hydroxylin dihydrochloride, proclorperazine, procainamide, aminophillin, cytochrome C, pentazocin, aprotinin, after 6 hours there is a change in drug properties.
Interactions in clinical testing: The urine glucose response may be false (-) with Fehling's or Benedict's solution. Positive antiglobulin (Coomb) tests, typically, have been reported in neonates whose mothers received midapezon at the time of delivery. Occasionally increases in serum ALT, ALP, AST, BUN and serum creatinine have been reported.

Midapezon was well tolerated and most of the unwanted side effects were mild and moderate.
Digestive: Diarrhea 3.9%, nausea and vomiting 0.6%. Skin and subcutaneous soft tissue: Skin allergy, erythema 0.6%, urticaria 0.8%. Blood: Long-term use of Midapezon may cause reversible leukopenia, positive Coomb's reaction in some patients, decrease in hemoglobin and red blood cells, transient decrease in eosinophils, platelets, and hypoprothrombinemia. .

Use caution when administering cefoperazone and sulbactam to patients allergic to penicillin. Pseudomembranous colitis has been reported in patients receiving cefoperazone and other broad-spectrum antibiotics. Disulfiram-like reactions have been reported in patients who consumed alcohol within 72 hours of cefoperazone administration. Patients should be advised not to drink alcohol while using cefoperazone/sulbactam injection.
Cefoperazone and sulbactam have been reported to cross the placental barrier. There are not enough well-controlled studies in pregnant women, so the drug should be used during pregnancy only when clearly needed.
Very small amounts of Cefoperazone and sulbactam have been reported in human milk. However, caution should be exercised when using the drug in nursing mothers.
Cefoperazone and sulbactam have no effect on people driving and using machines.
Above are the uses of Midapezon, patients should carefully read the instructions before using to get the best effect in the treatment of the disease.